Role of the capsular polysaccharide-like serotype-specific antigen in resistance of Actinobacillus actinomycetemcomitans to phagocytosis by human polymorphonuclear leukocytes.

abstract：:Inbred strain 2 guinea pigs were vaccinated with Mycobacterium bovis BCG or were left unvaccinated and challenged 6 weeks later by the respiratory route with virulent Mycobacterium tuberculosis. By using a double rosette assay with isotype-specific antibody-coated ox and uncoated rabbit erythrocytes, the proportions o...

journal_title：Infection and immunity

authors： Bartow RA,McMurray DN

更新日期：1989-05-01 00:00:00

abstract：:Burkholderia pseudomallei is a CDC tier 1 select agent that causes melioidosis, a severe disease in humans and animals. Persistent infections are common, and there is currently no vaccine available. Lipopolysaccharide (LPS) is a potential vaccine candidate. B. pseudomallei expresses three serologically distinct LPS ty...

journal_title：Infection and immunity

authors： Wikraiphat C,Saiprom N,Tandhavanant S,Heiss C,Azadi P,Wongsuvan G,Tuanyok A,Holden MT,Burtnick MN,Brett PJ,Peacock SJ,Chantratita N

更新日期：2015-05-01 00:00:00

abstract：:F344 rats chronically infected with Ureaplasma parvum develop two distinct profiles: asymptomatic urinary tract infection (UTI) and UTI complicated by struvite urolithiasis. To identify factors that affect disease outcome, we characterized the temporal host immune response during infection by histopathologic analysis ...

journal_title：Infection and immunity

authors： Reyes L,Alvarez S,Allam A,Reinhard M,Brown MB

更新日期：2009-10-01 00:00:00

abstract：:Transposon mutagenesis was used to analyze Mycoplasma pneumoniae cytadherence. Mycoplasmas were electroporated with Tn4001, and transformants were identified by antibiotic selection using gentamicin. The resulting colonies were screened for hemadsorption (HA) as an indicator for cytadherence. Six HA- colonies from ind...

journal_title：Infection and immunity

authors： Hedreyda CT,Krause DC

更新日期：1995-09-01 00:00:00

abstract：:We have examined the ability of peptidoglycan (PepG) and lipoteichoic acid (LTA) isolated from Staphylococcus aureus to induce the release of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and IL-10 in whole human blood and identified the cellular origins of these cytokines. Both PepG and LTA induced t...

journal_title：Infection and immunity

authors： Wang JE,Jørgensen PF,Almlöf M,Thiemermann C,Foster SJ,Aasen AO,Solberg R

更新日期：2000-07-01 00:00:00

abstract：:In a double-blind, randomized, and placebo-controlled previous trial, the efficacy of Vi-rEPA for typhoid fever in 2- to 5-year-olds was 89.0% for 46 months. Vi-rEPA contained 25 microg of Vi and induced a greater-than-eightfold rise in immunoglobulin G (IgG) anti-Vi in all of the vaccinees tested. In this investigati...

journal_title：Infection and immunity

authors： Canh DG,Lin FY,Thiem VD,Trach DD,Trong ND,Mao ND,Hunt S,Schneerson R,Robbins JB,Chu C,Shiloach J,Bryla DA,Bonnet MC,Schulz D,Szu SC

更新日期：2004-11-01 00:00:00

abstract：:The role of antibody in protection against infection with Cryptococcus neoformans is undefined. In this paper we describe the development of opsonic activity in the cerebrospinal fluid (CSF) of rabbits in response to cryptococcal meningitis. The opsonin appeared to be immunoglobulin G (IgG); the activity was heat stab...

journal_title：Infection and immunity

authors： Hobbs MM,Perfect JR,Granger DL,Durack DT

更新日期：1990-07-01 00:00:00

abstract：:Specific pathogen-free guinea pigs were infected via the respiratory route with viable, attenuated Mycobacterium tuberculosis H37Ra and maintained on purified isocaloric diets. The control diet contained 30% protein (ovalbumin) and 50 ppm of added zinc (50 micrograms/g), the low protein diet contained 10% protein and ...

journal_title：Infection and immunity

authors： McMurray DN,Carlomagno MA,Cumberland PA

更新日期：1983-02-01 00:00:00

abstract：:Streptococcus pneumoniae is a major pathogen in humans. The pathogenicity of this organism is related to its many virulence factors, the most important of which is the thick pneumococcal capsule that minimizes phagocytosis. Another virulence-associated trait is the tendency of this bacterium to undergo autolysis in st...

journal_title：Infection and immunity

authors： Martner A,Skovbjerg S,Paton JC,Wold AE

更新日期：2009-09-01 00:00:00

abstract：:Mycobacterium leprae are killed by myeloperoxidase (or eosinophil peroxidase), H2O2, and a halide, thus suggesting a mechanism for their destruction by peroxidase-containing phagocytes. ...

journal_title：Infection and immunity

authors： Klebanoff SJ,Shepard CC

更新日期：1984-05-01 00:00:00

abstract：:We are currently studying the soluble egg antigens of Schistosoma japonicum in an attempt to determine which antigens are potent immunogens. Previously, we demonstrated by Ouchterlony immunodiffusion and inhibition of the circumoval precipitin test that the glycoprotein fraction of soluble egg antigens contains the an...

journal_title：Infection and immunity

authors： Long GW,Lewert RM,Pelley RP

更新日期：1981-11-01 00:00:00

abstract：:Experiments were conducted in which rhesus monkeys were infected with mumps virus by inoculation into the parotid gland. Virus was isolated from buccal swab specimens from animals up to 6 days after inoculation. Immunofluorescence staining for mumps antigen was positive, and infectious virus was recovered from tissue ...

journal_title：Infection and immunity

authors： Flanagan TD,Andrada JA,Barron AL,Witebsky E

更新日期：1971-05-01 00:00:00

abstract：:A strain of a nutritionally deficient streptococcus was shown to undergo morphological aberrations according to pyridoxal concentrations in the growth medium. Filamentous rod-shaped cells, observed by electron microscopy, predominated in the presence of decreasing concentrations. Multiple invaginations in the outer ce...

journal_title：Infection and immunity

authors： Clark RB,Gordon RE,Bottone EJ,Reitano M

更新日期：1983-10-01 00:00:00

abstract：:The rat middle ear and lung clearance model has been used to show that the nontypeable Haemophilus influenzae 26-kDa outer membrane protein OMP26 is highly efficacious as a mucosal immunogen, inducing significantly enhanced clearance in immunized rats upon direct challenge of these two anatomic sites. Similarly, the c...

journal_title：Infection and immunity

authors： Kyd JM,Cripps AW,Novotny LA,Bakaletz LO

更新日期：2003-08-01 00:00:00

abstract：:Conjunctival infection of guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis confers immunity. However, the mechanism of resistance to this intracellular pathogen is not yet defined. In the study reported here, serum immunoglobulin was passively transferred with resultant titers in excess of th...

journal_title：Infection and immunity

authors： Watson RR,Mull JD,MacDonald AB,Thompson SE 3rd,Bear SE

更新日期：1973-04-01 00:00:00

abstract：:Pneumolysin, the cholesterol-dependent cytolysin of Streptococcus pneumoniae, induces inflammatory and apoptotic events in mammalian cells. Toll-like receptor 4 (TLR4) confers resistance to pneumococcal infection via its interaction with pneumolysin, but the underlying mechanisms remain to be identified. In the presen...

journal_title：Infection and immunity

authors： Srivastava A,Henneke P,Visintin A,Morse SC,Martin V,Watkins C,Paton JC,Wessels MR,Golenbock DT,Malley R

更新日期：2005-10-01 00:00:00

abstract：:Western blot (immunoblot) analysis of sera from cattle vaccinated with Brucella abortus S19 exhibit an elevated serologic response to Hsp62, the GroEL homolog (BaGroEL). Serologic screening of individual cows vaccinated with B. abortus S19 revealed no correlation between the immune response to BaGroEL and protection a...

journal_title：Infection and immunity

authors： Lin J,Adams LG,Ficht TA

更新日期：1996-10-01 00:00:00

abstract：:Treatment of mouse embryo fibroblasts (MEF) grown in vitro with purified staphylococcal exfoliative toxin (ET) increased the concanavalin A (Con A) agglutinability of MEF 3.5-fold over control cells. Possible explanations for this phenomenon were investigated. ET lacked proteolytic activity on denatured casein. Con A,...

journal_title：Infection and immunity

authors： Rogolsky M,Wiley BB,Keyhani M,Glasgow LA

更新日期：1974-12-01 00:00:00

abstract：:Borrelia burgdorferi, the causative agent of Lyme disease, has a complex genome consisting of a linear chromosome and up to 21 linear and circular plasmids. These plasmids encode numerous proteins critical to the spirochete's infectious cycle and many hypothetical proteins whose functions and requirements are unknown....

journal_title：Infection and immunity

authors： Bestor A,Stewart PE,Jewett MW,Sarkar A,Tilly K,Rosa PA

更新日期：2010-06-01 00:00:00

abstract：:Pseudomonas aeruginosa exotoxin A (PA), a potent protein synthesis inhibitor, was found to be a weak T-cell mitogen for murine splenocytes. Maximal stimulation of [3H]thymidine incorporation was obtained with 10 to 100 ng of toxin per ml following a 4-day induction. PA was also shown to be a polyclonal activator of cy...

journal_title：Infection and immunity

authors： Zehavi-Willner T

更新日期：1988-01-01 00:00:00

abstract：:One major outer membrane protein (P1) of Haemophilus influenzae type b (Hib), with an apparent molecular weight of 34,000 (34K) as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), has been shown to be heat modifiable. After heating at 100 degrees C for 5 min in 2% SDS, the P1 protein...

journal_title：Infection and immunity

authors： Gonzales FR,Leachman S,Norgard MV,Radolf JD,McCracken GH Jr,Evans C,Hansen EJ

更新日期：1987-12-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a major metabolic end product detected in deep periodontal pockets that is produced by resident periodontopathic microbiota associated with the progression of periodontitis. Treponema denticola, a member of the subgingival biofilm at disease sites, produces cystalysin, an enzyme that catabo...

journal_title：Infection and immunity

authors： Chu L,Dong Z,Xu X,Cochran DL,Ebersole JL

更新日期：2002-03-01 00:00:00

abstract：:Salivary gland lysates of the sand fly Lutzomyia longipalpis markedly enhance the course of infection with Leishmania major in mice. Here we examine various parameters of this phenomenon. The exacerbative effect of L. longipalpis salivary gland lysates occurred in five different mouse strains; however, the character o...

journal_title：Infection and immunity

authors： Theodos CM,Ribeiro JM,Titus RG

更新日期：1991-05-01 00:00:00

abstract：:Monoclonal antibodies (TpM 3, TpM 6, and TpM 19) against Toxoplasma gondii insoluble antigens were produced by the hybridization of NS-1, a mouse myeloma cell line, with spleen cells from mice immunized with T. gondii insoluble antigens. TpM 3, TpM 6, and TpM 19 were characterized by the dye test, the latex agglutinat...

journal_title：Infection and immunity

authors： Ogata K,Kasahara T,Shioiri-Nakano K,Igarashi I,Suzuki M

更新日期：1984-03-01 00:00:00

abstract：:Borrelia burgdorferi spirochetes that do not cause arthritis or carditis were developed and used to investigate Lyme disease pathogenesis. A clonal isolate of B. burgdorferi N40 (cN40), which induces disease in C3H/HeN (C3H) mice, was repeatedly passaged in vitro to generate nonpathogenic spirochetes. The passage 75 i...

journal_title：Infection and immunity

authors： Anguita J,Samanta S,Revilla B,Suk K,Das S,Barthold SW,Fikrig E

更新日期：2000-03-01 00:00:00

abstract：:Immunization of mice with Plasmodium berghei or Plasmodium yoelii synthetic linear peptide chimeras (LPCs) based on the circumsporozoite protein protects against experimental challenge with viable sporozoites. The immunogenicity of LPCs is significantly enhanced by spontaneous polymerization. To better understand the ...

journal_title：Infection and immunity

authors： Silva-Flannery LM,Cabrera-Mora M,Dickherber M,Moreno A

更新日期：2009-05-01 00:00:00

abstract：:Bartonella bacilliformis is the etiologic agent of Oroya fever in humans. Flagellum-mediated motility has been postulated as a major virulence factor for invasion of host cells. To address this hypothesis, we purified and characterized flagella from strain KC584 and then assessed their role in human erythrocyte associ...

journal_title：Infection and immunity

authors： Scherer DC,DeBuron-Connors I,Minnick MF

更新日期：1993-12-01 00:00:00

abstract：:The heat-labile enterotoxin (LT) of Escherichia coli is localized in the periplasm of the bacterial cell. Growth of an LT-producing strain of E. coli in the presence of bile salts, in concentrations within the range found in the human small intestine, caused leakage of LT into the culture medium. This leakage could be...

journal_title：Infection and immunity

authors： Hunt PD,Hardy SJ

更新日期：1991-01-01 00:00:00

abstract：:Fibronectin-binding proteins mediate Staphylococcus aureus internalization into nonphagocytic cells in vitro. We have investigated whether fibronectin-binding proteins are virulence factors in the pathogenesis of pneumonia by using S. aureus strain 8325-4 and isogenic mutants in which fibronectin-binding proteins were...

journal_title：Infection and immunity

authors： McElroy MC,Cain DJ,Tyrrell C,Foster TJ,Haslett C

更新日期：2002-07-01 00:00:00

abstract：:A major goal of current vaccine development is the induction of strong immune responses against protective antigens delivered by mucosal routes. One of the most promising approaches in that respect relies on the use of live recombinant vaccine carriers. In this study, Mycobacterium bovis BCG was engineered to produce ...

journal_title：Infection and immunity

authors： Kremer L,Dupré L,Riveau G,Capron A,Locht C

更新日期：1998-12-01 00:00:00