Activation of the complement system by Cryptococcus neoformans leads to binding of iC3b to the yeast.

abstract：:Previous studies have reported that human vascular endothelial cells lack the membrane-bound lipopolysaccharide (LPS) receptor, CD14 (mCD14). By optimizing assay conditions, including the selection of anti-CD14 monoclonal antibody, we now demonstrate that human umbilical vein endothelial cells (HUVEC) express CD14 on ...

journal_title：Infection and immunity

authors： Jersmann HP,Hii CS,Hodge GL,Ferrante A

更新日期：2001-01-01 00:00:00

abstract：:Helicobacter pylori strains frequently express Lewis X (Le(x)) and/or Le(y) on their cell surfaces as constituents of the O antigens of their lipopolysaccharide molecules. To assess the effect of Le(x) and Le(y) expression on the ability of H. pylori to colonize the mouse stomach and to adhere to epithelial cells, iso...

journal_title：Infection and immunity

authors： Takata T,El-Omar E,Camorlinga M,Thompson SA,Minohara Y,Ernst PB,Blaser MJ

更新日期：2002-06-01 00:00:00

abstract：:Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-s...

journal_title：Infection and immunity

authors： Jacobson ES,Jenkins ND,Todd JM

更新日期：1994-09-01 00:00:00

abstract：:A crude complex containing group C polysaccharide, outer membrane proteins, and lipopolysaccharide (LPS) was isolated from the cell-free culture liquid of Neisseria meningitidis serogroup C, serotype 2a. Group C polysaccharide and LPS were removed from this complex, resulting in an outer membrane complex and a purifie...

journal_title：Infection and immunity

authors： Beuvery EC,Miedema F,van Delft RW,Haverkamp J,Leussink AB,te Pas BJ,Teppema KS,Tiesjema RH

更新日期：1983-04-01 00:00:00

abstract：:Bacterial strains of Haemophilus species and Streptococcus pneumoniae were examined for synthesis of the enzyme immunoglobulin A1 (IgA1) protease. Of 36 H. influenzae strains examined, 35 produced IgA1 protease; strains included all six capsular types, unencapsulated variants of types b and d, and untypable H. influen...

journal_title：Infection and immunity

authors： Male CJ

更新日期：1979-10-01 00:00:00

abstract：:Larvae of Toxocara canis, a nematode parasite of dogs, infect humans, causing visceral and ocular larva migrans. In noncanid hosts, larvae neither grow nor differentiate but endure in a state of arrested development. Reasoning that parasite protein production is orientated to immune evasion, we undertook a random sequ...

journal_title：Infection and immunity

authors： Tetteh KK,Loukas A,Tripp C,Maizels RM

更新日期：1999-09-01 00:00:00

abstract：:Cells of the laboratory strain 3153A of Candida albicans can be stimulated to undergo high-frequency phenotypic switching by a low dose of UV. We have compared the adhesive properties of cells exhibiting the basic original smooth (o-smooth) phenotype and three switch phenotypes (star, irregular wrinkle, and revertant ...

journal_title：Infection and immunity

authors： Vargas K,Wertz PW,Drake D,Morrow B,Soll DR

更新日期：1994-04-01 00:00:00

abstract：:Only listeriolysin O (LLO)-producing strains of Listeria monocytogenes generate protective immunity in mice. Based on the findings that endogenous gamma interferon (IFN-gamma) production was induced only by such strains and that purified LLO could induce IFN-gamma from NK cells, we have postulated that LLO may play a ...

journal_title：Infection and immunity

authors： Tanabe Y,Xiong H,Nomura T,Arakawa M,Mitsuyama M

更新日期：1999-02-01 00:00:00

abstract：:Cell surface protein SSP-5 in the oral bacterium Streptococcus gordonii M5 binds human salivary agglutinin in a Ca(2+)-dependent reaction (D.R. Demuth, E.E. Golub, and D. Malamud, J. Biol. Chem. 265:7120-7126, 1990). The region of the gene encoding an N-terminal segment of a related polypeptide (SspA) in S. gordonii D...

journal_title：Infection and immunity

authors： Jenkinson HF,Terry SD,McNab R,Tannock GW

更新日期：1993-08-01 00:00:00

abstract：:We have previously shown that malaria parasites liberate exoantigens which, through a phospholipid component, stimulate mouse macrophages to secrete tumor necrosis factor (TNF), which are toxic to D-galactosamine-sensitized mice, and which therefore might be involved in pathology. Plasmodium yoelii exoantigens detoxif...

journal_title：Infection and immunity

authors： Bate CA,Taverne J,Playfair JH

更新日期：1992-05-01 00:00:00

abstract：:Previous studies demonstrated that Mycoplasma arthritidis strain 158 acquired a high degree of virulence upon lysogenization with bacteriophage MAV1. In the present study, the association between MAV1 and virulence was reexamined by creating new lysogens of 158 and of a relatively avirulent mutant, strain 158-1. In th...

journal_title：Infection and immunity

authors： Clapper B,Tu AH,Simmons WL,Dybvig K

更新日期：2004-12-01 00:00:00

abstract：:Pools of rat antiserum to Plasmodium berghei had different levels of protective activity as assessed by a passive transfer test. Preincubation of parasite inocula with an effective pool before injection did not significantly enhance protective activity. Removal of the antiserum from preincubated parasite inocula aboli...

journal_title：Infection and immunity

authors： Brown IN,Phillips RS

更新日期：1974-12-01 00:00:00

abstract：:Adherence of erythrocytes infected with Plasmodium falciparum to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis. However, the real importance of sequestration for infection and disease has never been fully assessed. The absence of an appro...

journal_title：Infection and immunity

authors： Mota MM,Jarra W,Hirst E,Patnaik PK,Holder AA

更新日期：2000-07-01 00:00:00

abstract：:Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. To circumvent this problem, we injected CpG DNA ...

journal_title：Infection and immunity

authors： Berchtold C,Panthel K,Jellbauer S,Köhn B,Roider E,Partilla M,Heesemann J,Endres S,Bourquin C,Rüssmann H

更新日期：2009-12-01 00:00:00

abstract：:Previous attempts to induce mucosal antibodies in rhesus monkeys by enteric immunization have resulted in only modest and short-lived responses, dominated by immunoglobulin M (IgM) antibodies in the plasma. In this study, two groups of rhesus monkeys were immunized intranasally three times at 2-week intervals with a b...

journal_title：Infection and immunity

authors： Russell MW,Moldoveanu Z,White PL,Sibert GJ,Mestecky J,Michalek S M

更新日期：1996-04-01 00:00:00

abstract：:Neonatal animals are generally very susceptible to infection with bacterial pathogens. However, we recently reported that neonatal mice are highly resistant to orogastric infection with Yersinia enterocolitica. Here, we show that proinflammatory responses greatly exceeding those in adults arise very rapidly in the mes...

journal_title：Infection and immunity

authors： Siefker DT,Echeverry A,Brambilla R,Fukata M,Schesser K,Adkins B

更新日期：2014-02-01 00:00:00

abstract：:A protein antigen called TR-o was isolated from supernatant of a sonically treated Reiter treponeme. The isolation procedure included anion-exchange chromatography on Whatman DE-52, hydrophobic interaction chromatography on decyl agarose, and finally gel filtration on Ac-A-22 Ultrogel. The fractionations were monitore...

journal_title：Infection and immunity

authors： Petersen CS,Pedersen NS,Axelsen NH

更新日期：1982-03-01 00:00:00

abstract：:Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae, and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and rely on utilizing iron from host transferrin (Tf) for growth and survival. The surface receptor proteins that mediate th...

journal_title：Infection and immunity

authors： Frandoloso R,Martínez-Martínez S,Calmettes C,Fegan J,Costa E,Curran D,Yu RH,Gutiérrez-Martín CB,Rodríguez-Ferri EF,Moraes TF,Schryvers AB

更新日期：2015-03-01 00:00:00

abstract：:Blastomyces dermatitidis is a thermally induced dimorphic fungus capable of causing lung and systemic infections in immunocompetent animal hosts. With the publication of genomic sequences from three different strains of B. dermatitidis and the development of RNA interference as a gene-silencing tool, it has become pos...

journal_title：Infection and immunity

authors： Krajaejun T,Wüthrich M,Gauthier GM,Warner TF,Sullivan TD,Klein BS

更新日期：2010-06-01 00:00:00

abstract：:A hallmark of Bartonella henselae is persistent bacteremia in cats despite the presence of a vigorous host immune response. To understand better the long-term survival of B. henselae in cats, we examined the feline humoral immune response to B. henselae outer membrane (OM) proteins in naturally and experimentally infe...

journal_title：Infection and immunity

authors： Chenoweth MR,Greene CE,Krause DC,Gherardini FC

更新日期：2004-06-01 00:00:00

abstract：:Recurrent pulmonary infections with Staphylococcus aureus and Pseudomonas aeruginosa are a major problem in cystic fibrosis (CF), leading to severe and progressive deterioration of the respiratory tract. Fibronectin (FN) has a binding site(s) for S. aureus and Streptococcus pyogenes. This bacterial bindings site(s) wa...

journal_title：Infection and immunity

authors： Stanislawski L,Sorin M

更新日期：1991-03-01 00:00:00

abstract：:Live or heat-killed cells of Streptococcus mutans specifically adhere to dextran previously synthesized on glass surfaces by the action of extracellular dextransucrase. ...

journal_title：Infection and immunity

authors： Kuramitsu HK

更新日期：1974-04-01 00:00:00

abstract：:Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked. Many pathogens have acquired the ability to sequester complement regulators from host plasma to evade complement attack. We describe here how Streptococcus pneumoniae adopts a st...

journal_title：Infection and immunity

authors： Haleem KS,Ali YM,Yesilkaya H,Kohler T,Hammerschmidt S,Andrew PW,Schwaeble WJ,Lynch NJ

更新日期：2018-12-19 00:00:00

abstract：:Human granulocytic ehrlichiosis (HGE) is an emerging febrile systemic disease caused by the HGE agent, an obligatory intracellular bacterium of granulocytes. The pathogenicity- and immunity-related mechanisms of HGE are unknown. In this study, several cytokines generated in human peripheral blood leukocytes (PBLs) inc...

journal_title：Infection and immunity

authors： Kim HY,Rikihisa Y

更新日期：2000-06-01 00:00:00

abstract：:EspC is an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC). The pathogenic role of EspC in EPEC infection is unknown. We have shown that the purified EspC produces enterotoxicity and cytotoxicity; for the latter effect, EspC must be internalized. However, the internalization mechanism is u...

journal_title：Infection and immunity

authors： Vidal JE,Navarro-García F

更新日期：2006-04-01 00:00:00

abstract：:Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial ti...

journal_title：Infection and immunity

authors： Nicolau DP,Freeman CD,Nightingale CH,Quintiliani R,Coe CJ,Maderazo EG,Cooper BW

更新日期：1993-04-01 00:00:00

abstract：:Chronic actinomycetoma associated with grain production was induced in BALB/c mice by subcutaneous inoculation of live Nocardia brasiliensis in Freund incomplete adjuvant into the hind footpads. Similar inoculation of N. asteroides and N. caviae resulted in local tumor formation which healed spontaneously after 5 mont...

journal_title：Infection and immunity

authors： Zlotnik H,Buckley HR

更新日期：1980-09-01 00:00:00

abstract：:Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y. pestis is capable of causing major epidemics; thus, there is a need for vaccine targets and a greater understanding of the role of these targets in pathogenesis. Two prime Y. pestis vaccine candida...

journal_title：Infection and immunity

authors： Weening EH,Cathelyn JS,Kaufman G,Lawrenz MB,Price P,Goldman WE,Miller VL

更新日期：2011-02-01 00:00:00

abstract：:A recombinant plasmid containing a 6.5-kb fragment of nontypeable Haemophilus influenzae (NTHI) chromosomal DNA was shown to confer a hemoglobin-haptoglobin-binding phenotype on Escherichia coli. Use of a mini-Tn10kan transposon for random insertion mutagenesis of this recombinant plasmid allowed localization of the N...

journal_title：Infection and immunity

authors： Maciver I,Latimer JL,Liem HH,Muller-Eberhard U,Hrkal Z,Hansen EJ

更新日期：1996-09-01 00:00:00

abstract：:Cell-free hemoglobin (Hb) is being developed as an erythrocyte substitute. We have previously demonstrated that cell-free Hb is an endotoxin-binding protein which disaggregates endotoxin and subsequently increases the biological activity of endotoxin in several in vitro assays. Because much of the morbidity and mortal...

journal_title：Infection and immunity

authors： Su D,Roth RI,Yoshida M,Levin J

更新日期：1997-04-01 00:00:00