Purification of a Reiter treponemal protein antigen that is immunologically related to an antigen in Treponema pallidum.

abstract：:The effect of the secondary infection with Toxoplasma gondii on antibody responses to unrelated antigens was examined in mice. A reinfection with 5 X 10(3) organisms did not affect either primary anti-sheep erythrocyte antibody responses, or anti-dinitrophenol antibody responses to dinitrophenylated keyhole limpet hem...

journal_title：Infection and immunity

authors： Suzuki Y,Kobayashi A

更新日期：1985-06-01 00:00:00

abstract：:Iron is limiting in the human host, and bacterial pathogens respond to this environment by regulating gene expression through the ferric uptake regulator protein (Fur). In vitro studies have demonstrated that Neisseria gonorrhoeae controls the expression of several critical genes through an iron- and Fur-mediated mech...

journal_title：Infection and immunity

authors： Agarwal S,King CA,Klein EK,Soper DE,Rice PA,Wetzler LM,Genco CA

更新日期：2005-07-01 00:00:00

abstract：:The gonococcal pilus is a primary virulence factor, providing the initial attachment of the bacterial cell to human mucosal tissues. Pilin, the major subunit of the pilus, can carry a wide spectrum of primary amino acid sequences which are generated by the action of a complex antigenic variation system. Changes in the...

journal_title：Infection and immunity

authors： Long CD,Madraswala RN,Seifert HS

更新日期：1998-05-01 00:00:00

abstract：:Previous studies suggested that nontypeable Haemophilus influenzae (NTHI) can form biofilms during human and chinchilla middle ear infections. Microscopic analysis of a 5-day biofilm of NTHI strain 2019 grown in a continuous-flow chamber revealed that the biofilm had a diffuse matrix interlaced with multiple water cha...

journal_title：Infection and immunity

authors： Greiner LL,Watanabe H,Phillips NJ,Shao J,Morgan A,Zaleski A,Gibson BW,Apicella MA

更新日期：2004-07-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is an important component of the innate immune system. It binds to the arrays of sugars commonly presented by microorganisms and activates the complement system independently of antibody. Despite detailed knowledge of the stereochemical basis of MBL binding, relatively little is known abou...

journal_title：Infection and immunity

authors： Devyatyarova-Johnson M,Rees IH,Robertson BD,Turner MW,Klein NJ,Jack DL

更新日期：2000-07-01 00:00:00

abstract：:We investigated the ability of two overlapping fragments of staphylococcal enterotoxin B (SEB), which encompass the whole toxin, to induce protection and also examined if passive transfer of chicken anti-SEB antibodies raised against the holotoxin could protect rhesus monkeys against aerosolized SEB. Although both fra...

journal_title：Infection and immunity

authors： LeClaire RD,Hunt RE,Bavari S

更新日期：2002-05-01 00:00:00

abstract：:The precise role of Leishmania glycoconjugate molecules including phosphoglycans (PGs) and lipophosphoglycan (LPG) on host cellular responses is still poorly defined. Here, we investigated the interaction of Leishmania major LPG2 null mutant (lpg2(-)), which lacks both PGs and LPG, with dendritic cells (DCs) and the s...

journal_title：Infection and immunity

authors： Liu D,Kebaier C,Pakpour N,Capul AA,Beverley SM,Scott P,Uzonna JE

更新日期：2009-08-01 00:00:00

abstract：:Cryptosporidial infections in severe combined immune deficient (SCID) mice produce a chronic disease state which in the later stages leads to extraintestinal involvement and hepatic dysfunction. To further characterize the infection dynamics in this model and monitor the changes in the hepatic system, a dose titration...

journal_title：Infection and immunity

authors： Mead JR,Ilksoy N,You X,Belenkaya Y,Arrowood MJ,Fallon MT,Schinazi RF

更新日期：1994-05-01 00:00:00

abstract：:Neutralizing antibodies were raised in mice that had been inoculated repeatedly with moderate quantities of human leukocyte interferon highly purified by affinity chromatography on immobilized anti-interferon globulins. Interferon preparations of lesser purity sensitized the mice to subsequent inoculations of interfer...

journal_title：Infection and immunity

authors： Dalton BJ,Ogburn CA,Paucker K

更新日期：1978-02-01 00:00:00

abstract：:We demonstrate that 2-month-old female B10.T(6R) mice are highly resistant to systemic infection with the KIM5 strain of Yersinia pestis and that B10.T(6R) mice become susceptible to Y. pestis infection by the age of 5 months. In this study, young (2-month-old) and middle-aged (5- to 12-month-old) B10.T(6R) mice were ...

journal_title：Infection and immunity

authors： Lambert ND,Langfitt DM,Nilles ML,Bradley DS

更新日期：2011-11-01 00:00:00

abstract：:Mannheimia haemolytica, a commensal organism of the upper respiratory tract in cattle, is the principal bacterial pathogen associated with the bovine respiratory disease complex. Adherence to the respiratory mucosa is a crucial event in its pathogenesis. However, the bacterial components that contribute to this proces...

journal_title：Infection and immunity

authors： Kisiela DI,Czuprynski CJ

更新日期：2009-01-01 00:00:00

abstract：:The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1₁₉) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1₁₉ (PyMSP1₁₉) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the M...

journal_title：Infection and immunity

authors： Alaro JR,Angov E,Lopez AM,Zhou H,Long CA,Burns JM Jr

更新日期：2012-07-01 00:00:00

abstract：:Immunoglobulin A1 (IgA1) proteases are produced by a number of different species of bacteria which cause infection at human mucosal surfaces. The sole substrate of these proteases is human IgA1. Cleavage is within the hinge region of IgA1, although there is variability in the exact peptide bond within the hinge region...

journal_title：Infection and immunity

authors： Grundy FJ,Plaut AG,Wright A

更新日期：1990-02-01 00:00:00

abstract：:Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial ti...

journal_title：Infection and immunity

authors： Nicolau DP,Freeman CD,Nightingale CH,Quintiliani R,Coe CJ,Maderazo EG,Cooper BW

更新日期：1993-04-01 00:00:00

abstract：:Pasteurella multocida is the causative agent of a number of diseases in animals, including fowl cholera. P. multocida strains simultaneously express two lipopolysaccharide (LPS) glycoforms (glycoforms A and B) that differ only in their inner core structure. Glycoform A contains a single 3-deoxy-d-manno-octulosonic aci...

journal_title：Infection and immunity

authors： Harper M,Cox AD,St Michael F,Ford M,Wilkie IW,Adler B,Boyce JD

更新日期：2010-09-01 00:00:00

abstract：:Trypanosoma brucei subsp. brucei and T. congolense incubated in homologous antibody at 0 degrees C for 30 min were lysed by subsequent addition of guinea pig complement. Trypanosomes incubated in antibody at 37 degrees C before complement treatment remained intact. Parasites bearing adsorbed antibody also remained int...

journal_title：Infection and immunity

authors： Balber AE,Bangs JD,Jones SM,Proia RL

更新日期：1979-06-01 00:00:00

abstract：:Acquired cellular immunity to infection with Mycobacterium tuberculosis is believed to reside in the capacity of mononuclear phagocytes of immunized animals to inhibit intracellular multiplication of the parasite. However, in macrophage tissue culture systems, it has been customary to employ streptomycin in the medium...

journal_title：Infection and immunity

authors： Patterson RJ,Youmans GP

更新日期：1970-01-01 00:00:00

abstract：:In studies of experimental Lyme disease, a major obstacle has been the unavailability of a suitable animal model. We found that irradiated LSH/Ss Lak hamsters developed arthritis after injection of Borrelia burgdorferi in the hind paws. When nonirradiated hamsters were injected in the hind paws with B. burgdorferi, ac...

journal_title：Infection and immunity

authors： Schmitz JL,Schell RF,Hejka A,England DM,Konick L

更新日期：1988-09-01 00:00:00

abstract：:Antibiotic-resistant recombinants obtained from mating antibiotic-resistant Escherichia coli with virulent, antibiotic-sensitive Salmonella typhimurium are generally avirulent. After 32 consecutive transfers, two of four avirulent recombinants regained their virulence without loss of episome-mediated resistance. ...

journal_title：Infection and immunity

authors： Thiele EH

更新日期：1970-10-01 00:00:00

abstract：:Clostridium botulinum neurotoxins (BoNTs) are the most toxic proteins for humans. The current clostridial-derived vaccines against BoNT intoxication have limitations including production and accessibility. Conditions were established to express the soluble receptor binding domain (heavy-chain receptor [HCR]) of BoNT s...

journal_title：Infection and immunity

authors： Baldwin MR,Tepp WH,Pier CL,Bradshaw M,Ho M,Wilson BA,Fritz RB,Johnson EA,Barbieri JT

更新日期：2005-10-01 00:00:00

abstract：:Brucella organisms are intracellular stealth pathogens of animals and humans. The bacteria overcome the assault of innate immunity at early stages of an infection. Removal of polymorphonuclear neutrophils (PMNs) at the onset of adaptive immunity against Brucella abortus favored bacterial elimination in mice. This was ...

journal_title：Infection and immunity

authors： Mora-Cartín R,Gutiérrez-Jiménez C,Alfaro-Alarcón A,Chaves-Olarte E,Chacón-Díaz C,Barquero-Calvo E,Moreno E

更新日期：2019-04-23 00:00:00

abstract：:Chronic actinomycetoma associated with grain production was induced in BALB/c mice by subcutaneous inoculation of live Nocardia brasiliensis in Freund incomplete adjuvant into the hind footpads. Similar inoculation of N. asteroides and N. caviae resulted in local tumor formation which healed spontaneously after 5 mont...

journal_title：Infection and immunity

authors： Zlotnik H,Buckley HR

更新日期：1980-09-01 00:00:00

abstract：:Salmonella infection can cause gastroenteritis in healthy individuals or a serious, systemic infection in immunocompromised patients and has a global impact. CD4 Th1 cells represent the main lymphocyte population that participates in bacterial clearance during both primary and secondary infections in mice of the H-2b ...

journal_title：Infection and immunity

authors： Labuda JC,Depew CE,Pham OH,Benoun JM,Ramirez NA,McSorley SJ

更新日期：2019-10-18 00:00:00

abstract：:Bacterial adherence to mucosal surfaces is an important virulence trait of pathogenic bacteria. Adhesion of enterotoxigenic Escherichia coli (ETEC) to the intestine is mediated by a number of antigenically distinct colonization factors (CFs). One of the most common CFs is CFA/I. This has a fimbrial structure composed ...

journal_title：Infection and immunity

authors： Jansson L,Tobias J,Lebens M,Svennerholm AM,Teneberg S

更新日期：2006-06-01 00:00:00

abstract：:Based upon the lipopolysaccharide (LPS) structure and antigenicity of Shigella group B, a strategy for broad cross-protection against 14 Shigella flexneri serotypes was designed. This strategy involves the use of two S. flexneri serotypes (2a and 3a), which together bear the all of the major antigenic group factors of...

journal_title：Infection and immunity

authors： Noriega FR,Liao FM,Maneval DR,Ren S,Formal SB,Levine MM

更新日期：1999-02-01 00:00:00

abstract：:To evaluate the enteropathogenicity of Aeromonas hydrophila and Plesiomonas shigelloides, the rate of isolation of these organisms was compared among individuals with and without diarrhea in Thailand. In two groups of American travelers, A. hydrophila, but not P. shigelloides, was associated with episodes of travelers...

journal_title：Infection and immunity

authors： Pitarangsi C,Echeverria P,Whitmire R,Tirapat C,Formal S,Dammin GJ,Tingtalapong M

更新日期：1982-02-01 00:00:00

abstract：:Bacillus anthracis, the causative agent of anthrax, relies on multiple virulence factors to subvert the host immune defense. Using Caenorhabditis elegans as an infection model, we screened approximately 5,000 transposon mutants of B. anthracis Sterne for decreased virulence. One of the attenuated mutants resulted in l...

journal_title：Infection and immunity

authors： Franks SE,Ebrahimi C,Hollands A,Okumura CY,Aroian RV,Nizet V,McGillivray SM

更新日期：2014-03-01 00:00:00

abstract：:We have developed a rapid, continuous method for real-time monitoring of biofilms, both in vitro and in a mouse infection model, through noninvasive imaging of bioluminescent bacteria colonized on Teflon catheters. Two important biofilm-forming bacterial pathogens, Staphylococcus aureus and Pseudomonas aeruginosa, wer...

journal_title：Infection and immunity

authors： Kadurugamuwa JL,Sin L,Albert E,Yu J,Francis K,DeBoer M,Rubin M,Bellinger-Kawahara C,Parr TR Jr,Contag PR

更新日期：2003-02-01 00:00:00

abstract：:Resistance to phagocytosis is a hallmark of virulent Streptococcus pyogenes (group A streptococcus). Surface-bound C5a peptidase reduces recruitment of phagocytes to the site of infection, and hyaluronic acid capsules and/or the M protein limit the uptake of streptococci. In this study the relative impact of M and M-l...

journal_title：Infection and immunity

authors： Ji Y,Schnitzler N,DeMaster E,Cleary P

更新日期：1998-11-01 00:00:00

abstract：:Previous reports have demonstrated that heat-stable (A-type) capsule on piliated enterotoxigenic Escherichia coli enhances colonization of enterotoxigenic E. coli in the small intestine and enhances virulence of enterotoxigenic E. coli. In this report, four encapsulated enterotoxigenic E. coli strains and one encapsul...

journal_title：Infection and immunity

authors： Runnels PL,Moon HW

更新日期：1984-09-01 00:00:00