Abstract:
:We investigated the ability of two overlapping fragments of staphylococcal enterotoxin B (SEB), which encompass the whole toxin, to induce protection and also examined if passive transfer of chicken anti-SEB antibodies raised against the holotoxin could protect rhesus monkeys against aerosolized SEB. Although both fragments of SEB were highly immunogenic, the fragments failed to protect mice whether they were injected separately or injected together. Passive transfer of antibody generated in chickens (immunoglobulin Y [IgY]) against the whole toxin suppressed cytokine responses and was protective in mice. All rhesus monkeys treated with the IgY specific for SEB up to 4 h after challenge survived lethal SEB aerosol exposure. These findings suggest that large fragments of SEB may not be ideal for productive vaccination, but passive transfer of SEB-specific antibodies protects nonhuman primates against lethal aerosol challenge. Thus, antibodies raised in chickens against the holotoxin may have potential therapeutic value within a therapeutic window of opportunity after SEB encounter.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
LeClaire RD,Hunt RE,Bavari Sdoi
10.1128/iai.70.5.2278-2281.2002keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
2278-81issue
5eissn
0019-9567issn
1098-5522journal_volume
70pub_type
杂志文章abstract::Iron is limiting in the human host, and bacterial pathogens respond to this environment by regulating gene expression through the ferric uptake regulator protein (Fur). In vitro studies have demonstrated that Neisseria gonorrhoeae controls the expression of several critical genes through an iron- and Fur-mediated mech...
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journal_title:Infection and immunity
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pub_type: 杂志文章
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journal_title:Infection and immunity
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更新日期:1978-04-01 00:00:00
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更新日期:2000-04-01 00:00:00
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journal_title:Infection and immunity
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pub_type: 杂志文章
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更新日期:1986-04-01 00:00:00
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更新日期:1996-08-01 00:00:00
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