Effect of Staphylococcus aureus delta-toxin on human granulocyte functions and platelet-activating-factor metabolism.

abstract：:Growth of a streptomycin-resistant strain of Escherichia coli (VL-2) in the presence of 30 microgram of streptomycin per ml resulted in the production by these bacteria of structurally altered, nonfunctional type 1 fimbriae. This strain, when grown in this subinhibitory concentration of streptomycin, became incapable ...

journal_title：Infection and immunity

authors： Eisenstein BI,Ofek I,Beachey EH

更新日期：1981-02-01 00:00:00

abstract：:Salmonella enterica serovar Paratyphi A O-specific polysaccharide (O-SP) was activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) and bound to tetanus toxoid (TT) with adipic acid dihydrazide as a linker (SPA-TT(1)) or directly (SPA-TT(2)). In mice, these two conjugates elicited high levels of imm...

journal_title：Infection and immunity

authors： Konadu EY,Lin FY,Hó VA,Thuy NT,Van Bay P,Thanh TC,Khiem HB,Trach DD,Karpas AB,Li J,Bryla DA,Robbins JB,Szu SC

更新日期：2000-03-01 00:00:00

abstract：:The genetic determinants of the 120-kDa cytotoxin of Actinobacillus pleuropneumoniae serotype 2 were isolated from a lambda DNA library by a plaque immunoblot technique. Expression of the 120-kDa polypeptide was confirmed by Western immunoblot analysis of infected Escherichia coli cell lysates, which were shown to be ...

journal_title：Infection and immunity

authors： MacDonald J,Rycroft AN

更新日期：1992-07-01 00:00:00

abstract：:Clostridium perfringens type B causes enteritis and enterotoxemia in domestic animals. By definition, these bacteria must produce alpha toxin (CPA), beta toxin (CPB) and epsilon toxin (ETX) although most type B strains also produce perfringolysin O (PFO) and beta2 toxin (CPB2). A recently identified Agr-like quorum-se...

journal_title：Infection and immunity

authors： Chen J,McClane BA

更新日期：2012-09-01 00:00:00

abstract：:The distribution of dengue-2 antigens was studied in infected monkey kidney cells (LLC MK2) using an indirect, horseradish peroxidase-conjugated immunoglobulin technique. This procedure allowed both light and electron microscopic examination of serial-step sections of individual cells cut in a plane perpendicular to t...

journal_title：Infection and immunity

authors： Cardiff RD,Lund JK

更新日期：1976-06-01 00:00:00

abstract：:Pneumolysin is a 471-amino-acid toxin produced by Streptococcus pneumoniae which has both cytolytic and complement activation properties. We have constructed a derivative of the type 2 S. pneumoniae strain D39 in which the portion of the pneumolysin gene encoding amino acids 55 to 437 has been deleted in-frame. The vi...

journal_title：Infection and immunity

authors： Berry AM,Ogunniyi AD,Miller DC,Paton JC

更新日期：1999-02-01 00:00:00

abstract：:In 2001, a bioterrorism attack involving Bacillus anthracis spore-laced letters resulted in 22 cases of inhalation anthrax, with five fatalities. This incident identified gaps in our health care system and precipitated a renewed interest in identifying both therapeutics and rapid diagnostic assays. To address those ga...

journal_title：Infection and immunity

authors： Rossi CA,Ulrich M,Norris S,Reed DS,Pitt LM,Leffel EK

更新日期：2008-12-01 00:00:00

abstract：:Ocular inflammation is one of the consequences of infection with the protozoan parasite Toxoplasma gondii. Even if lesions are self-healing in immunocompetent persons, they pose a lifetime risk of reactivation and are a serious threat to vision. As there are virtually no immunological data on reactivating ocular toxop...

journal_title：Infection and immunity

authors： Rochet É,Brunet J,Sabou M,Marcellin L,Bourcier T,Candolfi E,Pfaff AW

更新日期：2015-05-01 00:00:00

abstract：:A mouse lacking CD28, a T-cell costimulatory molecule, and STAT6, a transcription factor that mediates interleukin-4 (IL-4) signaling, was developed from parental CD28- and STAT6-deficient mice. STAT6/CD28(-/-) BALB/c mice that were 8 weeks old had a normal phenotype, and IL-4 production was induced following infectio...

journal_title：Infection and immunity

authors： Liu Q,Arseculeratne C,Liu Z,Whitmire J,Grusby MJ,Finkelman FD,Darling TN,Cheever AW,Swearengen J,Urban JF,Gause WC

更新日期：2004-07-01 00:00:00

abstract：:Lesions caused by Leishmania amazonensis normally heal, but relapses occur due to parasite persistence in host tissues. It has been proposed that infection of fibroblasts plays an important role in this process by providing the parasites with a safe haven in which to replicate. However, most previous studies have focu...

journal_title：Infection and immunity

authors： Morehead J,Coppens I,Andrews NW

更新日期：2002-08-01 00:00:00

abstract：:Genetically based natural resistance to brucellosis in cattle provides for novel strategies to control zoonotic diseases. Bovine NRAMP1, the homologue of a murine gene (Bcg), has been identified as a major candidate for controlling the in vivo resistant phenotype. We developed an in vitro model for expression of resis...

journal_title：Infection and immunity

authors： Barthel R,Feng J,Piedrahita JA,McMurray DN,Templeton JW,Adams LG

更新日期：2001-05-01 00:00:00

abstract：:Actinobacillus pleuropneumoniae serotype 7 strains are shown to spontaneously lose cytolytic activity with a frequency of approximately 10(-4). The phenotypic change is associated with the loss of approximately 8.5 kbp of chromosomal DNA. A genomic fragment encoding the cytolysin and its flanking sequences was cloned ...

journal_title：Infection and immunity

authors： Anderson C,Potter AA,Gerlach GF

更新日期：1991-11-01 00:00:00

abstract：:The actions of polymyxin B, rabbit polymorphonuclear lysosome extracts, 14 polycationic peptides (including defensin NP-2, cecropin P1, lactoferricin B, and active peptides from cationic protein 18 and bactenecin), EDTA, and Tris on Brucella spp. were studied, with other gram-negative bacteria as controls. Brucella sp...

journal_title：Infection and immunity

authors： Martínez de Tejada G,Pizarro-Cerdá J,Moreno E,Moriyón I

更新日期：1995-08-01 00:00:00

abstract：:Individuals with sickle cell anemia are subject to serious infections caused by a number of bacteria, including Salmonella species and Staphylococcus aureus. It has been suggested that in sickle cell anemia, extensive erythrophagocytosis by macrophages may interfere with their antibacterial function and thereby predis...

journal_title：Infection and immunity

authors： Hand WL,King-Thompson NL

更新日期：1983-06-01 00:00:00

abstract：:Nineteen of 22 female mice (CF1 strain) inoculated intragastrically with Treponema hyodysenteriae developed cecal and colonic lesions consisting of catarrhal inflammation, edema, and occasional hemorrhage. ...

journal_title：Infection and immunity

authors： Joens LA,Glock RD

更新日期：1979-08-01 00:00:00

abstract：:A multigene family of 58- to 60-kDa proteins, which are designated rhoptry-associated protein 1 (RAP-1) and which come from the parasites Babesia bigemina and Babesia bovis, is a target for vaccine development. The presence of multiple gene copies and conserved sequences and epitopes of RAP-1 implies that these protei...

journal_title：Infection and immunity

authors： Rodríguez SD,Palmer GH,McElwain TF,McGuire TC,Ruef BJ,Chitko-McKown MG,Brown WC

更新日期：1996-06-01 00:00:00

abstract：:Previous studies have shown that tumor necrosis factor alpha (TNF-alpha) plays a pathophysiologic role in sepsis induced in rat pups by group B streptococci (GBS). In this model, TNF-alpha is also partially responsible for the induction of interleukin-6 (IL-6). The present study was undertaken to investigate the role ...

journal_title：Infection and immunity

authors： Mancuso G,Tomasello F,Migliardo M,Delfino D,Cochran J,Cook JA,Teti G

更新日期：1994-11-01 00:00:00

abstract：:The ability of Klebsiella pneumoniae strains to resist the bactericidal activity of serum was quantitated. The K. pneumoniae strains tested included mutants lacking the capsular polysaccharide and mutants having a modified lipopolysaccharide structure. The last mutants were obtained as phage-resistant mutants, and the...

journal_title：Infection and immunity

authors： Tomás JM,Benedí VJ,Ciurana B,Jofre J

更新日期：1986-10-01 00:00:00

abstract：:Neonatal animals are generally very susceptible to infection with bacterial pathogens. However, we recently reported that neonatal mice are highly resistant to orogastric infection with Yersinia enterocolitica. Here, we show that proinflammatory responses greatly exceeding those in adults arise very rapidly in the mes...

journal_title：Infection and immunity

authors： Siefker DT,Echeverry A,Brambilla R,Fukata M,Schesser K,Adkins B

更新日期：2014-02-01 00:00:00

abstract：:Migration of the fungal pathogen Candida albicans across the endothelial cell layer is considered a prerequisite for the invasion of multiple organs occurring in systemic candidiasis. We developed an experimental system in which C. albicans migrates from a luminal compartment across a monolayer of bovine aortic endoth...

journal_title：Infection and immunity

authors： Zink S,Nass T,Rösen P,Ernst JF

更新日期：1996-12-01 00:00:00

abstract：:Fractionation of the culture medium showed that Streptococcus salivarius ATCC 25975 secreted a glucosyltransferase (Gtf) that was primer independent. On the basis of this observation, a gene library of S. salivarius chromosomal DNA cloned into lambda L47.1 was screened for a gene(s) coding for such an activity. As a r...

journal_title：Infection and immunity

authors： Simpson CL,Giffard PM,Jacques NA

更新日期：1995-02-01 00:00:00

abstract：:Porphyromonas gingivalis is a gram-negative anaerobic bacterium that is considered the key etiologic agent of chronic periodontitis. Arg- and Lys-gingipain cysteine proteinases produced by P. gingivalis are key virulence factors and are believed to be essential for significant tissue component degradation, leading to ...

journal_title：Infection and immunity

authors： Andrian E,Grenier D,Rouabhia M

更新日期：2004-08-01 00:00:00

abstract：:Two distinct and complementary pathways, one mediated by perforin and the other dependent upon CD95 (Fas), effect cell-mediated cytotoxicity. We examined the relative roles of these pathways in host defenses against the intracellular bacterial pathogen Listeria monocytogenes by using murine listeriosis as a model syst...

journal_title：Infection and immunity

authors： Jensen ER,Glass AA,Clark WR,Wing EJ,Miller JF,Gregory SH

更新日期：1998-09-01 00:00:00

abstract：:The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants...

journal_title：Infection and immunity

authors： Van Alst NE,Wellington M,Clark VL,Haidaris CG,Iglewski BH

更新日期：2009-10-01 00:00:00

abstract：:A Gram-negative, filamentous, rod-shaped bacillus which failed to grow in cell-free media was isolated in apparently pure culture from the bronchial scraping and washing of a laboratory rat suffering from chronic respiratory disease by inoculating embryonated chicken eggs via the allantoic route. None of the embryos d...

journal_title：Infection and immunity

authors： Ganaway JR,Spencer TH,Moore TD,Allen AM

更新日期：1985-02-01 00:00:00

abstract：:The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was...

journal_title：Infection and immunity

authors： Foulongne V,Walravens K,Bourg G,Boschiroli ML,Godfroid J,Ramuz M,O'Callaghan D

更新日期：2001-01-01 00:00:00

abstract：:The expression of the Shigella flexneri chromosomal aerobactin genes during growth of the bacterium within tissue culture cells was assayed. During intracellular growth, aerobactin promoter activity was repressed relative to the level observed in bacteria grown extracellularly, even when the bacteria had been starved ...

journal_title：Infection and immunity

authors： Headley V,Hong M,Galko M,Payne SM

更新日期：1997-02-01 00:00:00

abstract：:Regulation of the synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi, is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some serotype Typhi strains exhibit overexpression of Vi polysaccharide, which masks cl...

journal_title：Infection and immunity

authors： Santander J,Wanda SY,Nickerson CA,Curtiss R 3rd

更新日期：2007-03-01 00:00:00

abstract：:Knowledge of whether Mycobacterium tuberculosis resides within a relatively impermeable membrane-bound vacuole or is free within the cytoplasm within its host cell is central to an understanding of the immunobiology of this intracellular parasite but is a matter of controversy. To explore this issue, we assessed the a...

journal_title：Infection and immunity

authors： Clemens DL,Lee BY,Horwitz MA

更新日期：2002-10-01 00:00:00

abstract：:In experiments described herein, it was observed that guinea pigs with delayed-type hypersensitivity to tuberculoproteins under various experimental conditions, with or without passive transfer of serum from immune donors, manifested no acquired immunity against aerogenically induced tuberculosis. These results are di...

journal_title：Infection and immunity

authors： Reggiardo Z,Middlebrook G

更新日期：1974-05-01 00:00:00