听力与言语-语言病理学

行为科学

医学伦理学

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  • Exploiting Ca2+ signaling in T cells to advance cancer immunotherapy.

    abstract::Decades of basic research has established the importance of Ca2+ to various T cell functions, such as cytotoxicity, proliferation, differentiation and cytokine secretion. We now have a good understanding of how proximal TCR signaling initiates Ca2+ influx and how this influx subsequently changes transcriptional activi...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2020.101434

    authors: Meng X,Wu X,Zheng Y,Shang K,Jing R,Jiao P,Zhou C,Zhou J,Sun J

    更新日期:2020-06-01 00:00:00

  • Humoral immune responses: Unsung heroes of the war on cancer.

    abstract::Solid cancers progress from primordial lesions through complex interactions between tumor-promoting and anti-tumor immune cell types, ultimately leading to the orchestration of humoral and T cell adaptive immune responses, albeit in an immunosuppressive environment. B cells infiltrating most established tumors have be...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2020.101419

    authors: Conejo-Garcia JR,Biswas S,Chaurio R

    更新日期:2020-06-01 00:00:00

  • Development of autoantibody signatures for common cancers.

    abstract::A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available f...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2020.101388

    authors: Kobayashi M,Katayama H,Fahrmann JF,Hanash SM

    更新日期:2020-02-01 00:00:00

  • Il-10 producing T and B cells in allergy.

    abstract::The molecular and cellular mechanisms of allergen tolerance in humans have been intensively studied in the past few decades. The demonstration of epitope-specific T cell tolerance, particularly mediated by the immune suppressor functions of IL-10 led to a major conceptual change in this area more than 20 years ago. Cu...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2019.101326

    authors: Boonpiyathad T,Satitsuksanoa P,Akdis M,Akdis CA

    更新日期:2019-08-01 00:00:00

  • PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON.

    abstract::Interferon epsilon (IFNε) is a type I IFN with unusual patterns of expression and therefore, function. It is constitutively expressed by reproductive tract epithelium and regulated by hormones during estrus cycle, reproduction, and menopause and by exogenous hormones. The IFNe protein is encoded by a gene in the type ...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2019.101328

    authors: Marks ZRC,Campbell N,deWeerd NA,Lim SS,Gearing LJ,Bourke NM,Hertzog PJ

    更新日期:2019-06-01 00:00:00

  • Global virus outbreaks: Interferons as 1st responders.

    abstract::Outbreaks of severe virus infections with the potential to cause global pandemics are increasing. In many instances these outbreaks have been newly emerging (SARS coronavirus), re-emerging (Ebola virus, Zika virus) or zoonotic (avian influenza H5N1) virus infections. In the absence of a targeted vaccine or a pathogen-...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2019.101300

    authors: Wang BX,Fish EN

    更新日期:2019-06-01 00:00:00

  • CEACAM1 structure and function in immunity and its therapeutic implications.

    abstract::The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in the tumor environment and is strictly regulated on lymphocytes such ...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2019.101296

    authors: Kim WM,Huang YH,Gandhi A,Blumberg RS

    更新日期:2019-04-01 00:00:00

  • Senescent cell clearance by the immune system: Emerging therapeutic opportunities.

    abstract::Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory, metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but metabolically active cells that can secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype (...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2019.04.003

    authors: Prata LGPL,Ovsyannikova IG,Tchkonia T,Kirkland JL

    更新日期:2018-12-01 00:00:00

  • The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli.

    abstract::A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its pro...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2018.10.009

    authors: Nardini C,Moreau JF,Gensous N,Ravaioli F,Garagnani P,Bacalini MG

    更新日期:2018-12-01 00:00:00

  • Correlates of adjuvanticity: A review on adjuvants in licensed vaccines.

    abstract::After decades of slow progress, the last years have seen a rapid acceleration of the development of adjuvanted vaccines which have lately been approved for human use. These adjuvants consist of different components, e.g. aluminium salts, emulsions such as MF59 and AS03, Toll-like receptor (TLR) agonists (CpG ormonopho...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2018.05.001

    authors: Del Giudice G,Rappuoli R,Didierlaurent AM

    更新日期:2018-10-01 00:00:00

  • The potential of metabolic profiling for vaccine development.

    abstract::Recent technological advances have provided deeper insights into the role of small molecules in biological processes. Metabolic profiling has thus entered the arena of -omics studies and rapidly proven its value both as stand-alone and as complement to other more advanced approaches, notably transcriptomics. Here we d...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2018.07.002

    authors: Weiner J 3rd,Mohney RP,Kaufmann SHE

    更新日期:2018-10-01 00:00:00

  • Insights into the role of IL-32 in cancer.

    abstract::Interleukin 32 (IL-32) is a proinflammatory cytokine involved in the development of several diseases, including cancer. IL-32 is a rather peculiar cytokine because its protein structure does not show resemblance with any of the known cytokines, and an IL-32 receptor to facilitate extracellular signaling has not yet be...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2018.03.004

    authors: Sloot YJE,Smit JW,Joosten LAB,Netea-Maier RT

    更新日期:2018-08-01 00:00:00

  • High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells.

    abstract::Alarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity. HMGB1 serves a dual alarmin function. The protein can be emitted to alert...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2018.02.011

    authors: Andersson U,Yang H,Harris H

    更新日期:2018-08-01 00:00:00

  • Alarmins of the extracellular space.

    abstract::The ability of the immune system to discriminate between healthy-self, abnormal-self, and non-self has been attributed mainly to alarmins signaling as "danger signals". It is now evident, however, that alarmins are much more complex and can perform specialized functions that can regulate a wide spectrum of processes r...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2018.08.004

    authors: Dziki JL,Hussey G,Badylak SF

    更新日期:2018-08-01 00:00:00

  • Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment.

    abstract::Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co-opt MSCs and re-program their functional profile from normally trophic to pro-tumorigenic. These tumor-derived small vesicles called "TEX" carry and ...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2017.12.003

    authors: Whiteside TL

    更新日期:2018-02-01 00:00:00

  • Mesenchymal-myeloid interaction in the regulation of immunity.

    abstract::Several studies have demonstrated how different cell types of mesenchymal and myeloid origin can independently exhibit immunoregulatory activities. In response to inflammatory cues, they transcribe a molecular repertoire that restores the tissue microenvironment to what it was before the injury. There is accumulating ...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2018.01.002

    authors: Cheung TS,Dazzi F

    更新日期:2018-02-01 00:00:00

  • Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation.

    abstract::Nanotechnology-based strategies can dramatically impact the treatment, prevention and diagnosis of a wide range of diseases. Despite the unprecedented success achieved with the use of nanomaterials to address unmet biomedical needs and their particular suitability for the effective application of a personalized medici...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2017.09.003

    authors: Silva AL,Peres C,Conniot J,Matos AI,Moura L,Carreira B,Sainz V,Scomparin A,Satchi-Fainaro R,Préat V,Florindo HF

    更新日期:2017-12-01 00:00:00

  • Recent advances in clinical development of leukotriene B4 pathway drugs.

    abstract::The LTB4 pathway is an attractive target for therapeutic drug development. Two broad classes of drugs have been pursued: antagonists of the primary LTB4 receptors (BLT1 and BLT2) and inhibitors of LTA4 Hydrolase (LTA4H), the rate limiting enzyme in the production of LTB4. An initial wave of effort culminated in the 19...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2017.08.007

    authors: Bhatt L,Roinestad K,Van T,Springman EB

    更新日期:2017-10-01 00:00:00

  • The microbiome in anti-cancer therapy.

    abstract::The commensal microbiome constitutes an important modulator of host physiology and risk of disease, including cancer development and progression. Lately, the microbiome has been suggested to modulate the efficacy of anti-cancer treatment. Examples include chemotherapy and total body irradiation-induced barrier functio...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2017.04.001

    authors: Bashiardes S,Tuganbaev T,Federici S,Elinav E

    更新日期:2017-08-01 00:00:00

  • Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development.

    abstract::Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Reciprocally, uncontrolled immune responses, that may or may not be induced by dysbiosis, are central to the development of IBD and CAC. There has ...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2017.04.003

    authors: Kang M,Martin A

    更新日期:2017-08-01 00:00:00

  • Memory responses of natural killer cells.

    abstract::Natural killer (NK) cells have traditionally been classified as a cellular component of the innate immune system, given their ability to rapidly produce effector cytokines and kill infected or transformed cells without prior exposure. More recently, NK cells have been shown to possess features of adaptive immunity suc...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2017.08.012

    authors: Geary CD,Sun JC

    更新日期:2017-06-01 00:00:00

  • Clinical aspects of oral immunotherapy for the treatment of allergies.

    abstract::Studies on oral immunotherapy (OIT) have been increasing worldwide. Nevertheless, some concerns exist with this treatment. The rate of long-term sustained unresponsiveness is quite low; moreover, the desensitization or sustained unresponsiveness does not equate to tolerance. Furthermore, adverse reactions are frequent...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2017.07.008

    authors: Yanagida N,Sato S,Ebisawa M

    更新日期:2017-04-01 00:00:00

  • History and mechanisms of oral tolerance.

    abstract::Since its first description by Wells and Osbourne in 1911, oral tolerance has intrigued researchers due to its potential for therapeutic applications. Oral tolerance can be defined as an inhibition of specific immune responsiveness to subsequent parenteral injections of proteins to which an individual or animal has be...

    journal_title:Seminars in immunology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.smim.2017.07.004

    authors: Rezende RM,Weiner HL

    更新日期:2017-04-01 00:00:00

  • Macrophage phenotype in response to ECM bioscaffolds.

    abstract::Macrophage presence and phenotype are critical determinants of the healing response following injury. Downregulation of the pro-inflammatory macrophage phenotype has been associated with the therapeutic use of bioscaffolds composed of extracellular matrix (ECM), but phenotypic characterization of macrophages has typic...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2017.04.004

    authors: Huleihel L,Dziki JL,Bartolacci JG,Rausch T,Scarritt ME,Cramer MC,Vorobyov T,LoPresti ST,Swineheart IT,White LJ,Brown BN,Badylak SF

    更新日期:2017-02-01 00:00:00

  • The modern interleukin-1 superfamily: Divergent roles in obesity.

    abstract::Obesity is now recognised as a chronic, low-grade inflammatory disease contributing to insulin resistance, type 2 diabetes (T2D) and cardiovascular disease (CVD). Multiple mechanisms leading to the low grade inflammation in this setting have been suggested. Due to the complexity and interconnection of inflammatory and...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2016.10.001

    authors: Lee MK,Yvan-Charvet L,Masters SL,Murphy AJ

    更新日期:2016-10-01 00:00:00

  • Integrating immunometabolism and macrophage diversity.

    abstract::Macrophages are heterogeneous cells that play a key role in inflammatory and tissue reparative responses. Over the past decade it has become clear that shifts in cellular metabolism are important determinants of macrophage function and phenotype. At the same time, our appreciation of macrophage diversity in vivo has a...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2016.10.004

    authors: Artyomov MN,Sergushichev A,Schilling JD

    更新日期:2016-10-01 00:00:00

  • Nutrient sensing, signal transduction and immune responses.

    abstract::Most cells in the body have a constant supply of nutrients, which are required to sustain cellular metabolism and functions. In contrast, cells of the immune system can encounter conditions with a limited nutrient supply during the course of an immune response. Cells of the immune system frequently operate in complex ...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2016.09.001

    authors: Walls J,Sinclair L,Finlay D

    更新日期:2016-10-01 00:00:00

  • Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application.

    abstract::Periodontitis is a dysbiotic inflammatory disease leading to the destruction of the tooth-supporting tissues. Current therapies are not always effective and this prevalent oral disease continues to be a significant health and economic burden. Early clinical studies have associated periodontitis with elevated complemen...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2016.03.006

    authors: Hajishengallis G,Hajishengallis E,Kajikawa T,Wang B,Yancopoulou D,Ricklin D,Lambris JD

    更新日期:2016-06-01 00:00:00

  • Cytotoxic mechanisms of immunotherapy: Harnessing complement in the action of anti-tumor monoclonal antibodies.

    abstract::Several mAbs that have been approved for the treatment of cancer make use of complement-dependent cytotoxicity (CDC) to eliminate tumor cells. Comprehensive investigations, based on in vitro studies, mouse models and analyses of patient blood samples after mAb treatment have provided key insights into the details of i...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2016.03.003

    authors: Taylor RP,Lindorfer MA

    更新日期:2016-06-01 00:00:00

  • Neutrophils in animal models of autoimmune disease.

    abstract::Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and propagation of autoimmunity. The use of mouse models, which allow eith...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2016.04.001

    authors: Németh T,Mócsai A,Lowell CA

    更新日期:2016-04-01 00:00:00

  • Cancer immunotherapy targeting neoantigens.

    abstract::Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential b...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2015.11.002

    authors: Lu YC,Robbins PF

    更新日期:2016-02-01 00:00:00

  • Reprogramming the tumor microenvironment to enhance adoptive cellular therapy.

    abstract::The frontiers of cancer immunotherapy are extending in terms of both the range of cancer types that can potentially be targeted and the types of therapeutics that are in clinical development. The use of adoptive cellular therapy (ACT) and its derivative, chimeric antigen receptor (CAR) T cells, is currently limited to...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2015.11.003

    authors: Beavis PA,Slaney CY,Kershaw MH,Gyorki D,Neeson PJ,Darcy PK

    更新日期:2016-02-01 00:00:00

  • Development and function of tissue resident macrophages in mice.

    abstract::Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversit...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2016.03.017

    authors: Kierdorf K,Prinz M,Geissmann F,Gomez Perdiguero E

    更新日期:2015-12-01 00:00:00

  • Molecular features of macrophage activation.

    abstract::Cellular activation is mainly defined as the response of a cell to exogenous signals eventually leading to changes in protein expression and cellular function. Originally, macrophage activation was mainly associated with phagocytic function. Later other effector functions such as cytokine secretion, upregulation of ce...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2016.03.009

    authors: Schultze JL,Schmidt SV

    更新日期:2015-12-01 00:00:00

  • Celiac disease: Autoimmunity in response to food antigen.

    abstract::Celiac disease (CD) is an increasingly common disease of the small intestine that occurs in genetically susceptible subjects by ingestion of cereal gluten proteins. Gluten is highly abundant in the modern diet and well tolerated by most individuals. In CD, however, an erroneous but highly specific, adaptive immune res...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2015.11.001

    authors: Stamnaes J,Sollid LM

    更新日期:2015-09-01 00:00:00

  • Molecular and epigenetic basis of macrophage polarized activation.

    abstract::Macrophages are unique cells for origin, heterogeneity and plasticity. At steady state most of macrophages are derived from fetal sources and maintained in adulthood through self-renewing. Despite sharing common progenitors, a remarkable heterogeneity characterized tissue-resident macrophages indicating that local sig...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2015.10.003

    authors: Porta C,Riboldi E,Ippolito A,Sica A

    更新日期:2015-08-01 00:00:00

  • Macrophage activation in human diseases.

    abstract::It is becoming increasingly accepted that macrophages play a crucial role in many diseases associated with chronic inflammation, including atherosclerosis, obesity, diabetes, cancer, skin diseases, and even neurodegenerative diseases. It is therefore not surprising that macrophages in human diseases have gained signif...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2015.07.003

    authors: Schultze JL,Schmieder A,Goerdt S

    更新日期:2015-08-01 00:00:00

  • Virus-induced preferential antibody gene-usage and its importance in humoral autoimmunity.

    abstract::It is known that even the adaptive components of the immune system are based on genetic traits common to all individuals, and that diversity is shaped by the lifelong contacts with different non-self antigens, including those found on infectious pathogens. Besides the individual differences, some of these common trait...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2015.03.008

    authors: Cappelletti F,Clementi N,Mancini N,Clementi M,Burioni R

    更新日期:2015-03-01 00:00:00

  • Viral immune evasion: Lessons in MHC class I antigen presentation.

    abstract::The MHC class I antigen presentation pathway enables cells infected with intracellular pathogens to signal the presence of the invader to the immune system. Cytotoxic T lymphocytes are able to eliminate the infected cells through recognition of pathogen-derived peptides presented by MHC class I molecules at the cell s...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2015.03.010

    authors: van de Weijer ML,Luteijn RD,Wiertz EJ

    更新日期:2015-03-01 00:00:00

  • Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis.

    abstract::Despite the overwhelming success of immunization in reducing, and even eliminating, the global threats posed by a wide spectrum of infectious diseases, attempts to do the same for tuberculosis (TB) have failed to date. While most effective vaccines act by eliciting neutralizing antibodies, T cells are the primary medi...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.smim.2014.10.003

    authors: Urdahl KB

    更新日期:2014-12-01 00:00:00

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