abstract：:Solid cancers progress from primordial lesions through complex interactions between tumor-promoting and anti-tumor immune cell types, ultimately leading to the orchestration of humoral and T cell adaptive immune responses, albeit in an immunosuppressive environment. B cells infiltrating most established tumors have be...

journal_title：Seminars in immunology

authors： Conejo-Garcia JR,Biswas S,Chaurio R

更新日期：2020-06-01 00:00:00

abstract：:Decades of basic research has established the importance of Ca2+ to various T cell functions, such as cytotoxicity, proliferation, differentiation and cytokine secretion. We now have a good understanding of how proximal TCR signaling initiates Ca2+ influx and how this influx subsequently changes transcriptional activi...

journal_title：Seminars in immunology

authors： Meng X,Wu X,Zheng Y,Shang K,Jing R,Jiao P,Zhou C,Zhou J,Sun J

更新日期：2020-06-01 00:00:00

abstract：:A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available f...

journal_title：Seminars in immunology

authors： Kobayashi M,Katayama H,Fahrmann JF,Hanash SM

更新日期：2020-02-01 00:00:00

abstract：:The molecular and cellular mechanisms of allergen tolerance in humans have been intensively studied in the past few decades. The demonstration of epitope-specific T cell tolerance, particularly mediated by the immune suppressor functions of IL-10 led to a major conceptual change in this area more than 20 years ago. Cu...

journal_title：Seminars in immunology

authors： Boonpiyathad T,Satitsuksanoa P,Akdis M,Akdis CA

更新日期：2019-08-01 00:00:00

abstract：:Interferon epsilon (IFNε) is a type I IFN with unusual patterns of expression and therefore, function. It is constitutively expressed by reproductive tract epithelium and regulated by hormones during estrus cycle, reproduction, and menopause and by exogenous hormones. The IFNe protein is encoded by a gene in the type ...

journal_title：Seminars in immunology

authors： Marks ZRC,Campbell N,deWeerd NA,Lim SS,Gearing LJ,Bourke NM,Hertzog PJ

更新日期：2019-06-01 00:00:00

abstract：:Outbreaks of severe virus infections with the potential to cause global pandemics are increasing. In many instances these outbreaks have been newly emerging (SARS coronavirus), re-emerging (Ebola virus, Zika virus) or zoonotic (avian influenza H5N1) virus infections. In the absence of a targeted vaccine or a pathogen-...

journal_title：Seminars in immunology

authors： Wang BX,Fish EN

更新日期：2019-06-01 00:00:00

abstract：:The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in the tumor environment and is strictly regulated on lymphocytes such ...

journal_title：Seminars in immunology

authors： Kim WM,Huang YH,Gandhi A,Blumberg RS

更新日期：2019-04-01 00:00:00

abstract：:A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its pro...

journal_title：Seminars in immunology

authors： Nardini C,Moreau JF,Gensous N,Ravaioli F,Garagnani P,Bacalini MG

更新日期：2018-12-01 00:00:00

abstract：:Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory, metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but metabolically active cells that can secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype (...

journal_title：Seminars in immunology

authors： Prata LGPL,Ovsyannikova IG,Tchkonia T,Kirkland JL

更新日期：2018-12-01 00:00:00

abstract：:After decades of slow progress, the last years have seen a rapid acceleration of the development of adjuvanted vaccines which have lately been approved for human use. These adjuvants consist of different components, e.g. aluminium salts, emulsions such as MF59 and AS03, Toll-like receptor (TLR) agonists (CpG ormonopho...

journal_title：Seminars in immunology

authors： Del Giudice G,Rappuoli R,Didierlaurent AM

更新日期：2018-10-01 00:00:00

abstract：:Recent technological advances have provided deeper insights into the role of small molecules in biological processes. Metabolic profiling has thus entered the arena of -omics studies and rapidly proven its value both as stand-alone and as complement to other more advanced approaches, notably transcriptomics. Here we d...

journal_title：Seminars in immunology

authors： Weiner J 3rd,Mohney RP,Kaufmann SHE

更新日期：2018-10-01 00:00:00

abstract：:Alarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity. HMGB1 serves a dual alarmin function. The protein can be emitted to alert...

journal_title：Seminars in immunology

authors： Andersson U,Yang H,Harris H

更新日期：2018-08-01 00:00:00

abstract：:Interleukin 32 (IL-32) is a proinflammatory cytokine involved in the development of several diseases, including cancer. IL-32 is a rather peculiar cytokine because its protein structure does not show resemblance with any of the known cytokines, and an IL-32 receptor to facilitate extracellular signaling has not yet be...

journal_title：Seminars in immunology

authors： Sloot YJE,Smit JW,Joosten LAB,Netea-Maier RT

更新日期：2018-08-01 00:00:00

abstract：:The ability of the immune system to discriminate between healthy-self, abnormal-self, and non-self has been attributed mainly to alarmins signaling as "danger signals". It is now evident, however, that alarmins are much more complex and can perform specialized functions that can regulate a wide spectrum of processes r...

journal_title：Seminars in immunology

authors： Dziki JL,Hussey G,Badylak SF

更新日期：2018-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co-opt MSCs and re-program their functional profile from normally trophic to pro-tumorigenic. These tumor-derived small vesicles called "TEX" carry and ...

journal_title：Seminars in immunology

authors： Whiteside TL

更新日期：2018-02-01 00:00:00

abstract：:Several studies have demonstrated how different cell types of mesenchymal and myeloid origin can independently exhibit immunoregulatory activities. In response to inflammatory cues, they transcribe a molecular repertoire that restores the tissue microenvironment to what it was before the injury. There is accumulating ...

journal_title：Seminars in immunology

authors： Cheung TS,Dazzi F

更新日期：2018-02-01 00:00:00

abstract：:Nanotechnology-based strategies can dramatically impact the treatment, prevention and diagnosis of a wide range of diseases. Despite the unprecedented success achieved with the use of nanomaterials to address unmet biomedical needs and their particular suitability for the effective application of a personalized medici...

journal_title：Seminars in immunology

authors： Silva AL,Peres C,Conniot J,Matos AI,Moura L,Carreira B,Sainz V,Scomparin A,Satchi-Fainaro R,Préat V,Florindo HF

更新日期：2017-12-01 00:00:00

abstract：:The LTB4 pathway is an attractive target for therapeutic drug development. Two broad classes of drugs have been pursued: antagonists of the primary LTB4 receptors (BLT1 and BLT2) and inhibitors of LTA4 Hydrolase (LTA4H), the rate limiting enzyme in the production of LTB4. An initial wave of effort culminated in the 19...

journal_title：Seminars in immunology

authors： Bhatt L,Roinestad K,Van T,Springman EB

更新日期：2017-10-01 00:00:00

abstract：:The commensal microbiome constitutes an important modulator of host physiology and risk of disease, including cancer development and progression. Lately, the microbiome has been suggested to modulate the efficacy of anti-cancer treatment. Examples include chemotherapy and total body irradiation-induced barrier functio...

journal_title：Seminars in immunology

authors： Bashiardes S,Tuganbaev T,Federici S,Elinav E

更新日期：2017-08-01 00:00:00

abstract：:Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Reciprocally, uncontrolled immune responses, that may or may not be induced by dysbiosis, are central to the development of IBD and CAC. There has ...

journal_title：Seminars in immunology

authors： Kang M,Martin A

更新日期：2017-08-01 00:00:00

abstract：:Natural killer (NK) cells have traditionally been classified as a cellular component of the innate immune system, given their ability to rapidly produce effector cytokines and kill infected or transformed cells without prior exposure. More recently, NK cells have been shown to possess features of adaptive immunity suc...

journal_title：Seminars in immunology

authors： Geary CD,Sun JC

更新日期：2017-06-01 00:00:00

abstract：:Since its first description by Wells and Osbourne in 1911, oral tolerance has intrigued researchers due to its potential for therapeutic applications. Oral tolerance can be defined as an inhibition of specific immune responsiveness to subsequent parenteral injections of proteins to which an individual or animal has be...

journal_title：Seminars in immunology

authors： Rezende RM,Weiner HL

更新日期：2017-04-01 00:00:00

abstract：:Studies on oral immunotherapy (OIT) have been increasing worldwide. Nevertheless, some concerns exist with this treatment. The rate of long-term sustained unresponsiveness is quite low; moreover, the desensitization or sustained unresponsiveness does not equate to tolerance. Furthermore, adverse reactions are frequent...

journal_title：Seminars in immunology

authors： Yanagida N,Sato S,Ebisawa M

更新日期：2017-04-01 00:00:00

abstract：:Macrophage presence and phenotype are critical determinants of the healing response following injury. Downregulation of the pro-inflammatory macrophage phenotype has been associated with the therapeutic use of bioscaffolds composed of extracellular matrix (ECM), but phenotypic characterization of macrophages has typic...

journal_title：Seminars in immunology

authors： Huleihel L,Dziki JL,Bartolacci JG,Rausch T,Scarritt ME,Cramer MC,Vorobyov T,LoPresti ST,Swineheart IT,White LJ,Brown BN,Badylak SF

更新日期：2017-02-01 00:00:00

abstract：:Most cells in the body have a constant supply of nutrients, which are required to sustain cellular metabolism and functions. In contrast, cells of the immune system can encounter conditions with a limited nutrient supply during the course of an immune response. Cells of the immune system frequently operate in complex ...

journal_title：Seminars in immunology

authors： Walls J,Sinclair L,Finlay D

更新日期：2016-10-01 00:00:00

abstract：:Obesity is now recognised as a chronic, low-grade inflammatory disease contributing to insulin resistance, type 2 diabetes (T2D) and cardiovascular disease (CVD). Multiple mechanisms leading to the low grade inflammation in this setting have been suggested. Due to the complexity and interconnection of inflammatory and...

journal_title：Seminars in immunology

authors： Lee MK,Yvan-Charvet L,Masters SL,Murphy AJ

更新日期：2016-10-01 00:00:00

abstract：:Macrophages are heterogeneous cells that play a key role in inflammatory and tissue reparative responses. Over the past decade it has become clear that shifts in cellular metabolism are important determinants of macrophage function and phenotype. At the same time, our appreciation of macrophage diversity in vivo has a...

journal_title：Seminars in immunology

authors： Artyomov MN,Sergushichev A,Schilling JD

更新日期：2016-10-01 00:00:00

abstract：:Several mAbs that have been approved for the treatment of cancer make use of complement-dependent cytotoxicity (CDC) to eliminate tumor cells. Comprehensive investigations, based on in vitro studies, mouse models and analyses of patient blood samples after mAb treatment have provided key insights into the details of i...

journal_title：Seminars in immunology

authors： Taylor RP,Lindorfer MA

更新日期：2016-06-01 00:00:00

abstract：:Periodontitis is a dysbiotic inflammatory disease leading to the destruction of the tooth-supporting tissues. Current therapies are not always effective and this prevalent oral disease continues to be a significant health and economic burden. Early clinical studies have associated periodontitis with elevated complemen...

journal_title：Seminars in immunology

authors： Hajishengallis G,Hajishengallis E,Kajikawa T,Wang B,Yancopoulou D,Ricklin D,Lambris JD

更新日期：2016-06-01 00:00:00

abstract：:Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and propagation of autoimmunity. The use of mouse models, which allow eith...

journal_title：Seminars in immunology

authors： Németh T,Mócsai A,Lowell CA

更新日期：2016-04-01 00:00:00

abstract：:The frontiers of cancer immunotherapy are extending in terms of both the range of cancer types that can potentially be targeted and the types of therapeutics that are in clinical development. The use of adoptive cellular therapy (ACT) and its derivative, chimeric antigen receptor (CAR) T cells, is currently limited to...

journal_title：Seminars in immunology

authors： Beavis PA,Slaney CY,Kershaw MH,Gyorki D,Neeson PJ,Darcy PK

更新日期：2016-02-01 00:00:00

abstract：:Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential b...

journal_title：Seminars in immunology

authors： Lu YC,Robbins PF

更新日期：2016-02-01 00:00:00

abstract：:Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversit...

journal_title：Seminars in immunology

authors： Kierdorf K,Prinz M,Geissmann F,Gomez Perdiguero E

更新日期：2015-12-01 00:00:00

abstract：:Cellular activation is mainly defined as the response of a cell to exogenous signals eventually leading to changes in protein expression and cellular function. Originally, macrophage activation was mainly associated with phagocytic function. Later other effector functions such as cytokine secretion, upregulation of ce...

journal_title：Seminars in immunology

authors： Schultze JL,Schmidt SV

更新日期：2015-12-01 00:00:00

abstract：:Celiac disease (CD) is an increasingly common disease of the small intestine that occurs in genetically susceptible subjects by ingestion of cereal gluten proteins. Gluten is highly abundant in the modern diet and well tolerated by most individuals. In CD, however, an erroneous but highly specific, adaptive immune res...

journal_title：Seminars in immunology

authors： Stamnaes J,Sollid LM

更新日期：2015-09-01 00:00:00

abstract：:It is becoming increasingly accepted that macrophages play a crucial role in many diseases associated with chronic inflammation, including atherosclerosis, obesity, diabetes, cancer, skin diseases, and even neurodegenerative diseases. It is therefore not surprising that macrophages in human diseases have gained signif...

journal_title：Seminars in immunology

authors： Schultze JL,Schmieder A,Goerdt S

更新日期：2015-08-01 00:00:00

abstract：:Macrophages are unique cells for origin, heterogeneity and plasticity. At steady state most of macrophages are derived from fetal sources and maintained in adulthood through self-renewing. Despite sharing common progenitors, a remarkable heterogeneity characterized tissue-resident macrophages indicating that local sig...

journal_title：Seminars in immunology

authors： Porta C,Riboldi E,Ippolito A,Sica A

更新日期：2015-08-01 00:00:00

abstract：:It is known that even the adaptive components of the immune system are based on genetic traits common to all individuals, and that diversity is shaped by the lifelong contacts with different non-self antigens, including those found on infectious pathogens. Besides the individual differences, some of these common trait...

journal_title：Seminars in immunology

authors： Cappelletti F,Clementi N,Mancini N,Clementi M,Burioni R

更新日期：2015-03-01 00:00:00

abstract：:The MHC class I antigen presentation pathway enables cells infected with intracellular pathogens to signal the presence of the invader to the immune system. Cytotoxic T lymphocytes are able to eliminate the infected cells through recognition of pathogen-derived peptides presented by MHC class I molecules at the cell s...

journal_title：Seminars in immunology

authors： van de Weijer ML,Luteijn RD,Wiertz EJ

更新日期：2015-03-01 00:00:00

abstract：:Despite the introduction almost a century ago of Mycobacterium bovis BCG (BCG), an attenuated form of M. bovis that is used as a vaccine against Mycobacterium tuberculosis, tuberculosis remains a global health threat and kills more than 1.5 million people each year. This is mostly because BCG fails to prevent pulmonar...

journal_title：Seminars in immunology

authors： Behar SM,Carpenter SM,Booty MG,Barber DL,Jayaraman P

更新日期：2014-12-01 00:00:00