Abstract：
:A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its progression, seem to be sufficient to initiate the aging process and to fuel it. Others, like exposure to environmental compounds or infections, are temporary and resolve within a (relatively) short time. In both cases, however, a cellular memory of the event can be established by means of epigenetic modulation of the genome. In this review we will specifically discuss the relationship between epigenetics and inflammaging. In particular, we will show how age-associated epigenetic modifications concerned with heterochromatin loss and gene-specific remodelling, can promote inflammaging. Furthermore, we will recall how the exposure to specific nutritional, environmental and microbial stimuli can affect the rate of inflammaging through epigenetic mechanisms, touching also on the recent insight given by the concept of trained immunity.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Nardini C,Moreau JF,Gensous N,Ravaioli F,Garagnani P,Bacalini MGdoi
10.1016/j.smim.2018.10.009subject
Has Abstractpub_date
2018-12-01 00:00:00pages
49-60eissn
1044-5323issn
1096-3618pii
S1044-5323(18)30021-6journal_volume
40pub_type
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