Cancer immunotherapy targeting neoantigens.

Abstract:

:Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.

journal_name

Semin Immunol

journal_title

Seminars in immunology

authors

Lu YC,Robbins PF

doi

10.1016/j.smim.2015.11.002

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

22-7

issue

1

eissn

1044-5323

issn

1096-3618

pii

S1044-5323(15)00073-1

journal_volume

28

pub_type

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