Abstract：
:The molecular and cellular mechanisms of allergen tolerance in humans have been intensively studied in the past few decades. The demonstration of epitope-specific T cell tolerance, particularly mediated by the immune suppressor functions of IL-10 led to a major conceptual change in this area more than 20 years ago. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory of T and B cells, the immune suppressive function of secreted factors, such as IL-10, IL-35, IL-1 receptor antagonist and TGF-β, immune suppressive functions of surface molecules such as CTLA-4 and PD-1, the production IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues. In this review, we explain the importance of the role of IL-10 in allergen tolerance.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Boonpiyathad T,Satitsuksanoa P,Akdis M,Akdis CAdoi
10.1016/j.smim.2019.101326subject
Has Abstractpub_date
2019-08-01 00:00:00pages
101326eissn
1044-5323issn
1096-3618pii
S1044-5323(19)30029-6journal_volume
44pub_type
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