Abstract：
:The MHC class I antigen presentation pathway enables cells infected with intracellular pathogens to signal the presence of the invader to the immune system. Cytotoxic T lymphocytes are able to eliminate the infected cells through recognition of pathogen-derived peptides presented by MHC class I molecules at the cell surface. In the course of evolution, many viruses have acquired inhibitors that target essential stages of the MHC class I antigen presentation pathway. Studies on these immune evasion proteins reveal fascinating strategies used by viruses to elude the immune system. Viral immunoevasins also constitute great research tools that facilitate functional studies on the MHC class I antigen presentation pathway, allowing the investigation of less well understood routes, such as TAP-independent antigen presentation and cross-presentation of exogenous proteins. Viral immunoevasins have also helped to unravel more general cellular processes. For instance, basic principles of ER-associated protein degradation via the ubiquitin-proteasome pathway have been resolved using virus-induced degradation of MHC class I as a model. This review highlights how viral immunoevasins have increased our understanding of MHC class I-restricted antigen presentation.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
van de Weijer ML,Luteijn RD,Wiertz EJdoi
10.1016/j.smim.2015.03.010subject
Has Abstractpub_date
2015-03-01 00:00:00pages
125-37issue
2eissn
1044-5323issn
1096-3618pii
S1044-5323(15)00018-4journal_volume
27pub_type
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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pub_type： 社论
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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