Abstract:
:Most cells in the body have a constant supply of nutrients, which are required to sustain cellular metabolism and functions. In contrast, cells of the immune system can encounter conditions with a limited nutrient supply during the course of an immune response. Cells of the immune system frequently operate in complex nutrient restricted microenvironments such as tumour or inflammatory sites. The concentrations of key nutrients such as glucose and certain amino acids, can be low at these sites, and this can have an impact upon immune cell function. Nutrient sufficiency is important to supply the metabolic and biosynthetic pathways of immune cells. In addition nutrients can also act as important cues that influence immunological signalling pathways to affect the function of immune cells. This review will describe the various nutrient sensing signalling pathways and discuss the evidence that nutrients are critical signals that shape immune responses.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Walls J,Sinclair L,Finlay Ddoi
10.1016/j.smim.2016.09.001subject
Has Abstractpub_date
2016-10-01 00:00:00pages
396-407issue
5eissn
1044-5323issn
1096-3618pii
S1044-5323(16)30090-2journal_volume
28pub_type
杂志文章,评审abstract::The BLyS family of receptors includes two cytokines, BLyS and APRIL; and three receptors, BR3, BCMA and TACI. Together, these regulate the size and composition of peripheral B cell pools. The multiplicity of ligand-receptor sets, in conjunction with differential receptor expression, alternative binding partners and di...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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abstract::Increasing interest in the initial steps of hemopoiesis in the embryo is prompted by the lack of information about the primordial origin and the nature of hemopoietic stem cells. It appears critical to understand the emergence, diversification and differentiation potential of hemopoietic cells in the preliver embryo. ...
journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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abstract::Protein tyrosine phosphatases (PTPs) are a family of enzymes that modulate the cellular level of tyrosine phosphorylation. Based on cellular location, they are classified as receptor like or intracellular PTPs. Structure and function studies have led to the understanding of the enzymatic mechanism of this class of enz...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2000.0209
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2001.0345
更新日期:2002-04-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2006.04.004
更新日期:2006-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 社论
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1044-5323(02)00057-x
更新日期:2002-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 历史文章,杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2007.04.006
更新日期:2007-08-01 00:00:00
abstract::Signals from the precursor-B cell receptor (pre-BCR) are essential for selection and clonal expansion of pre-B cells that have performed productive immunoglobulin heavy chain V(D)J recombination. In the mouse, the downstream signaling molecules SLP-65 and Btk cooperate to limit proliferation and induce differentiation...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2005.10.002
更新日期:2006-02-01 00:00:00
abstract::Ten seven-transmembrane-domain G protein-coupled receptors have been identified that are functional HIV-1, HIV-2 and SIV coreceptors. However, the specific structures these receptors have in common that enable them to mediate HIV entry are unknown. Structure-function analyses have revealed that the determinants of cor...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1998.0130
更新日期:1998-06-01 00:00:00
abstract::Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential b...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2015.11.002
更新日期:2016-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2011.01.010
更新日期:2011-04-01 00:00:00
abstract::B cell tolerance is described as the absence of a measurable antibody forming response to an antigenic challenge. The establishment of antigen-specific tolerance requires, by definition, engagement of the B cell antigen-specific receptor. However, only in some circumstances does this engagement lead to tolerance, whil...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
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abstract::V(D)J recombination consists of a DNA cleavage reaction catalysed by RAG1 and RAG2, followed by an end-joining reaction that utilizes the cell's double-strand break repair machinery. Genes essential for the end-joining reaction include: XRCC4 encoding a protein of unknown enzymatic function; XRCC5 and XRCC6 encoding 8...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1997.0070
更新日期:1997-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2014.09.003
更新日期:2014-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00
abstract::Solid cancers progress from primordial lesions through complex interactions between tumor-promoting and anti-tumor immune cell types, ultimately leading to the orchestration of humoral and T cell adaptive immune responses, albeit in an immunosuppressive environment. B cells infiltrating most established tumors have be...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2020.101419
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2020.101388
更新日期:2020-02-01 00:00:00
abstract::Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversit...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2016.03.017
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abstract::The identification of the common lymphoid progenitors in mouse bone marrow allows us to directly assess the regulatory mechanisms of lymphoid lineage commitment. The unexpected finding of a latent myeloid differentiation potential in lymphoid progenitors sheds light on the importance of cytokine receptor expression at...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2002-12-01 00:00:00
abstract::Apoptosis of activated lymphocytes is critical to immune homeostasis. The cell surface receptor Fas is an important mediator of lymphocyte apoptosis; defective Fas expression causes accumulation of lymphocytes and autoimmune disease in mice. Apoptosis defects due to mutations of Fas have also been found in a rare huma...
journal_title:Seminars in immunology
pub_type: 杂志文章
doi:10.1006/smim.1996.0056
更新日期:1997-02-01 00:00:00
abstract::CD4+ regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed t...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2011.11.009
更新日期:2012-02-01 00:00:00
abstract::Autoantigens that contain DNA, RNA, or self-IgG are preferred targets for autoantibodies in systemic lupus erythematosus (SLE). B cells promote SLE pathogenesis by producing autoantibodies, activating autoreactive T cells, and secreting cytokines. We discuss how certain autoreactive B cells are selectively activated, ...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2006.12.005
更新日期:2007-02-01 00:00:00
abstract::It is known that even the adaptive components of the immune system are based on genetic traits common to all individuals, and that diversity is shaped by the lifelong contacts with different non-self antigens, including those found on infectious pathogens. Besides the individual differences, some of these common trait...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2015.03.008
更新日期:2015-03-01 00:00:00
abstract::During lymphocyte development, cell-fate decisions are determined by a myriad of signals produced by the micro- environment of the thymus and the bone marrow. These yet to be fully defined developmental cues regulate stage-specific gene expression, and the extraordinarily well-characterized stages of T and B cell deve...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1998.0153
更新日期:1999-02-01 00:00:00