Abstract：
:Recent technological advances have provided deeper insights into the role of small molecules in biological processes. Metabolic profiling has thus entered the arena of -omics studies and rapidly proven its value both as stand-alone and as complement to other more advanced approaches, notably transcriptomics. Here we describe the potential of metabolic profiling for vaccinology embedded in the context of infection and immunity. This discussion is preceded by a description of the relevant technical and analytical tools for biological interpretation of metabolic data. Although not as widely applied as other -omics technologies, we believe that metabolic profiling can make important contributions to the better understanding of mechanisms underlying vaccine-induced responses and their effects on the prevention of infection or disease.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Weiner J 3rd,Mohney RP,Kaufmann SHEdoi
10.1016/j.smim.2018.07.002subject
Has Abstractpub_date
2018-10-01 00:00:00pages
44-51eissn
1044-5323issn
1096-3618pii
S1044-5323(18)30027-7journal_volume
39pub_type
杂志文章,评审abstract：:The identification of the common lymphoid progenitors in mouse bone marrow allows us to directly assess the regulatory mechanisms of lymphoid lineage commitment. The unexpected finding of a latent myeloid differentiation potential in lymphoid progenitors sheds light on the importance of cytokine receptor expression at...
journal_title：Seminars in immunology
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abstract：:Monoclonal antibodies (MAb) specific for lymphocyte markers can be considered as very specific immunomodulating drugs for treatment of allograft rejection and autoimmune diseases. Although the selection of potentially useful specificities of MAb can be made in rodents, human specific MAb can only be evaluated in man o...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
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journal_title：Seminars in immunology
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abstract：:The germinal center is a critical locus in the production of protective immunity, but its function is poorly understood. Studies of mutant forms of CD19 revealed differences in signaling in different compartments inside the germinal center, and structural findings indicate a selective role in the interaction with foll...
journal_title：Seminars in immunology
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2004.09.005
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journal_title：Seminars in immunology
pub_type： 杂志文章
doi：10.1016/j.smim.2011.04.002
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2009.01.001
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2007.10.016
更新日期：2007-12-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.2000.0296
更新日期：2001-02-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1991-03-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2006.07.010
更新日期：2006-12-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.2001.0345
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2015.10.003
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2015.07.003
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
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doi：10.1016/j.smim.2009.10.001
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1991-03-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1991-11-01 00:00:00
abstract：:During lymphocyte development, cell-fate decisions are determined by a myriad of signals produced by the micro- environment of the thymus and the bone marrow. These yet to be fully defined developmental cues regulate stage-specific gene expression, and the extraordinarily well-characterized stages of T and B cell deve...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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abstract：:In humans, blood is commonly monitored to provide surrogates of disease progression and assess immune status. However, the varied, rapid and atypical alterations in lymphocyte subsets which may occur in blood in response to pathogens, are not predictive of changes in the bulk of the immune system. A hallmark of human ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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abstract：:It is now well established that the progression of T cell development requires interactions between the surfaces of thymocytes and thymic stromal cells. For example, the maturation of CD4+8+ cells into functional CD4+ or CD8+ cells requires TCR/MHC interactions, which, depending on the specificity of the particular TC...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1994.1028
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