Abstract：
:Natural killer (NK) cells have traditionally been classified as a cellular component of the innate immune system, given their ability to rapidly produce effector cytokines and kill infected or transformed cells without prior exposure. More recently, NK cells have been shown to possess features of adaptive immunity such as clonal expansion, longevity, and robust recall responses. NK cell memory can be broadly divided into two categories: antigen-specific and antigen-independent. In the first case, exposure to certain viral or hapten stimuli endows NK cells with antigen-specific immunological memory, similar to T and B cells. In the second case, exposure of NK cells to specific cytokine milieus can imprint long-lasting changes on effector functions, resulting in antigen-independent memory-like NK cells. In this review, we discuss the various conditions that promote generation of these two categories of memory NK cells, and the mechanistic requirements underlying these processes.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Geary CD,Sun JCdoi
10.1016/j.smim.2017.08.012subject
Has Abstractpub_date
2017-06-01 00:00:00pages
11-19eissn
1044-5323issn
1096-3618pii
S1044-5323(17)30031-3journal_volume
31pub_type
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