Abstract:
:Nanotechnology-based strategies can dramatically impact the treatment, prevention and diagnosis of a wide range of diseases. Despite the unprecedented success achieved with the use of nanomaterials to address unmet biomedical needs and their particular suitability for the effective application of a personalized medicine, the clinical translation of those nanoparticulate systems has still been impaired by the limited understanding on their interaction with complex biological systems. As a result, unexpected effects due to unpredicted interactions at biomaterial and biological interfaces have been underlying the biosafety concerns raised by the use of nanomaterials. This review explores the current knowledge on how nanoparticle (NP) physicochemical and surface properties determine their interactions with innate immune cells, with particular attention on the activation of pattern-recognition receptors and inflammasome. A critical perspective will additionally address the impact of biological systems on the effect of NP on immune cell activity at the molecular level. We will discuss how the understanding of the NP-innate immune cell interactions can significantly add into the clinical translation by guiding the design of nanomedicines with particular effect on targeted cells, thus improving their clinical efficacy while minimizing undesired but predictable toxicological effects.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Silva AL,Peres C,Conniot J,Matos AI,Moura L,Carreira B,Sainz V,Scomparin A,Satchi-Fainaro R,Préat V,Florindo HFdoi
10.1016/j.smim.2017.09.003subject
Has Abstractpub_date
2017-12-01 00:00:00pages
3-24eissn
1044-5323issn
1096-3618pii
S1044-5323(17)30040-4journal_volume
34pub_type
杂志文章,评审abstract::Many immune cells can detect the direction and intensity of an extracellular chemical gradient, and migrate toward the source of stimulus. This process, called chemotaxis, is essential for immune system function and homeostasis, and its deregulation is associated with serious diseases. Chemotaxis is initiated by chemo...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2004.09.005
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abstract::Recently, there have been a number of reports that gamma delta T cells are stimulated by heat shock, or stress, proteins. Although some alpha beta T cells are capable of recognizing heat shock proteins, we speculate that most or a group of gamma delta cells generally recognize this type of antigen. Recognition of heat...
journal_title:Seminars in immunology
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doi:
更新日期:1991-03-01 00:00:00
abstract::A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its pro...
journal_title:Seminars in immunology
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abstract::In humans, blood is commonly monitored to provide surrogates of disease progression and assess immune status. However, the varied, rapid and atypical alterations in lymphocyte subsets which may occur in blood in response to pathogens, are not predictive of changes in the bulk of the immune system. A hallmark of human ...
journal_title:Seminars in immunology
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abstract::Interferon epsilon (IFNε) is a type I IFN with unusual patterns of expression and therefore, function. It is constitutively expressed by reproductive tract epithelium and regulated by hormones during estrus cycle, reproduction, and menopause and by exogenous hormones. The IFNe protein is encoded by a gene in the type ...
journal_title:Seminars in immunology
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abstract::Antibody production is crucial for a successful vaccine response. Beyond the ability of vitamin A (VA) and its active metabolite, all-trans-retinoic acid (RA) to restore growth in VA-deficient animals, supplementation with VA and/or treatment with RA can augment antibody responses in both VA-deficient and VA-adequate ...
journal_title:Seminars in immunology
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abstract::The humoral arm of the immune system provides robust protection against extracellular pathogens via the production of antibody molecules that neutralize or facilitate the destruction of microorganisms. However, the humoral immune system also provides a significant barrier to solid organ transplantation due to the anti...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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abstract::The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in the tumor environment and is strictly regulated on lymphocytes such ...
journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract::Autoimmune diseases have been studied from the perspective of an abnormal immune response in genetically vulnerable hosts. Although the immune response is responsible for the initiation of autoimmune diseases, the effectors of the disease process likely involves cytokines such as interleukin-1 (IL-1) and tumor necrosi...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1992-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2016.03.006
更新日期:2016-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2011.01.006
更新日期:2011-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2013.05.002
更新日期:2013-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1990-03-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:1989-09-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2014.10.005
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1993.1003
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journal_title:Seminars in immunology
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doi:
更新日期:1992-04-01 00:00:00
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doi:10.1006/smim.1993.1018
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 评论,杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
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