Abstract：
:Pentraxins are highly conserved components of the humoral arm of innate immunity. They include the short pentraxins C reactive protein (CRP) and serum amyloid P component (SAP), and the long pentraxin PTX3. These are soluble pattern-recognition molecules that are present in the blood and body fluids, and share the ability to recognize pathogens and promote their disposal. CRP and SAP are produced systemically in the liver while PTX3 is produced locally in a number of tissues, macrophages and neutrophils being major sources of this long pentraxin. Pentraxins interact with components of the classical and lectin pathways of Complement as well as with Complement regulators. In particular, PTX3 recognizes C1q, factor H, MBL and ficolins, where these interactions amplify the repertoire of microbial recognition and effector functions of the Complement system. The complex interaction of pentraxins with the Complement system at different levels has broad implications for host defence and regulation of inflammation.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Inforzato A,Doni A,Barajon I,Leone R,Garlanda C,Bottazzi B,Mantovani Adoi
10.1016/j.smim.2013.05.002subject
Has Abstractpub_date
2013-02-01 00:00:00pages
79-85issue
1eissn
1044-5323issn
1096-3618pii
S1044-5323(13)00031-6journal_volume
25pub_type
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