Abstract：
:Naturally arising CD4(+) regulatory T cells are critical mediators of peripheral self tolerance and immune homeostasis. Emerging evidence suggests that these cells are a dedicated T cell lineage constitutively acting in a dominant, cell extrinsic manner to regulate immune function. These observations are driving a reevaluation of our understanding of the regulation of immune homeostasis and peripheral tolerance. But despite a growing body of phenomenological data, an understanding of the molecular mechanisms underlying CD4(+) regulatory T cell development has only recently begun to emerge. This review highlights the major molecular pathways that have been implicated to date in the development of this T cell lineage.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Fontenot JD,Rudensky AYdoi
10.1016/j.smim.2003.12.002keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
73-80issue
2eissn
1044-5323issn
1096-3618pii
S1044532303001064journal_volume
16pub_type
杂志文章,评审abstract：:Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory, metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but metabolically active cells that can secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype (...
journal_title：Seminars in immunology
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2005-02-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1044-5323(02)00127-6
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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abstract：:It is now well established that the progression of T cell development requires interactions between the surfaces of thymocytes and thymic stromal cells. For example, the maturation of CD4+8+ cells into functional CD4+ or CD8+ cells requires TCR/MHC interactions, which, depending on the specificity of the particular TC...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2012-10-01 00:00:00
