Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development.


:Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Reciprocally, uncontrolled immune responses, that may or may not be induced by dysbiosis, are central to the development of IBD and CAC. There has been a surge of interest in investigating the relationship between microbiota, inflammation and CAC. In this review, we discuss recent findings related to gut microbiota and chronic immune-mediated diseases, such as IBD and CAC. Moreover, the molecular mechanisms underlying the roles of chronic inflammation in CAC are examined. Finally, we discuss the development of novel microbiota-based therapeutics for IBD and colorectal cancer.


Semin Immunol


Seminars in immunology


Kang M,Martin A




Has Abstract


2017-08-01 00:00:00












  • Interleukin-1 and tumor necrosis factor: effector cytokines in autoimmune diseases.

    abstract::Autoimmune diseases have been studied from the perspective of an abnormal immune response in genetically vulnerable hosts. Although the immune response is responsible for the initiation of autoimmune diseases, the effectors of the disease process likely involves cytokines such as interleukin-1 (IL-1) and tumor necrosi...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Dinarello CA

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  • Reprogramming the tumor microenvironment to enhance adoptive cellular therapy.

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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  • Molecular features of macrophage activation.

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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  • Structure and signalling functions of C3 receptors on human B cells.

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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  • On the stochastic regulation of interleukin-2 transcription.

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    journal_title:Seminars in immunology

    pub_type: 评论,杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    更新日期:2009-08-01 00:00:00

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Hendriks RW,Kersseboom R

    更新日期:2006-02-01 00:00:00

  • Plasmacytoid dendritic cells in the skin: to sense or not to sense nucleic acids.

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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  • Cancer immunotherapy targeting neoantigens.

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Lu YC,Robbins PF

    更新日期:2016-02-01 00:00:00

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    更新日期:1992-06-01 00:00:00

  • Macrophage activation in human diseases.

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Schultze JL,Schmieder A,Goerdt S

    更新日期:2015-08-01 00:00:00

  • Human follicular dendritic cells: function, origin and development.

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: van Nierop K,de Groot C

    更新日期:2002-08-01 00:00:00

  • Do the CD4 and CD8 lineages represent parallel pathways?

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Spain LM,Yelon D,Berg LJ

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  • The protean immune cell synapse: a supramolecular structure with many functions.

    abstract::Heterogeneity in the supramolecular organization of immunological synapses arises from the involvement of different cells, distinct environmental stimuli, and varying levels of protein expression. There may also be heterogeneity in the types and amounts of cell surface proteins and lipids that transfer between lymphoc...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


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    更新日期:2003-12-01 00:00:00

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    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Silva AL,Peres C,Conniot J,Matos AI,Moura L,Carreira B,Sainz V,Scomparin A,Satchi-Fainaro R,Préat V,Florindo HF

    更新日期:2017-12-01 00:00:00

  • Developmental plasticity of lymphoid progenitors.

    abstract::The identification of the common lymphoid progenitors in mouse bone marrow allows us to directly assess the regulatory mechanisms of lymphoid lineage commitment. The unexpected finding of a latent myeloid differentiation potential in lymphoid progenitors sheds light on the importance of cytokine receptor expression at...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Prohaska SS,Scherer DC,Weissman IL,Kondo M

    更新日期:2002-12-01 00:00:00

  • Costimulatory pathways in transplantation.

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    journal_title:Seminars in immunology

    pub_type: 杂志文章


    authors: Pilat N,Sayegh MH,Wekerle T

    更新日期:2011-08-01 00:00:00

  • BAFF, APRIL and human B cell disorders.

    abstract::B cells require signals from multiple sources for their development from precursor cells, and differentiation into effector cells. BAFF has been identified as a critical regulator of B cell development and differentiation. Defects in the production of BAFF and/or expression of its receptors have been associated with a...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Tangye SG,Bryant VL,Cuss AK,Good KL

    更新日期:2006-10-01 00:00:00

  • Anatomical features of anti-viral immunity in the respiratory tract.

    abstract::The mucosal surfaces of the lungs are a major portal of entry for virus infections and there are urgent needs for new vaccines that promote effective pulmonary immunity. However, we have only a rudimentary understanding of the requirements for effective cellular immunity in the respiratory tract. Recent studies have r...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Woodland DL,Randall TD

    更新日期:2004-06-01 00:00:00

  • Human T cell receptor gamma delta + T cells.

    abstract::TCR gamma delta + T cells represent a minority of CD3+ T cells in many species including man. The molecular structure of the TCR gamma and delta loci in man is well understood. The gamma and delta loci contain V, D, J and C gene segments. These segments do not rearrange randomly but in a coordinated, ordered fashion d...

    journal_title:Seminars in immunology

    pub_type: 杂志文章,评审


    authors: Spits H

    更新日期:1991-03-01 00:00:00