Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development.

Abstract:

:Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Reciprocally, uncontrolled immune responses, that may or may not be induced by dysbiosis, are central to the development of IBD and CAC. There has been a surge of interest in investigating the relationship between microbiota, inflammation and CAC. In this review, we discuss recent findings related to gut microbiota and chronic immune-mediated diseases, such as IBD and CAC. Moreover, the molecular mechanisms underlying the roles of chronic inflammation in CAC are examined. Finally, we discuss the development of novel microbiota-based therapeutics for IBD and colorectal cancer.

journal_name

Semin Immunol

journal_title

Seminars in immunology

authors

Kang M,Martin A

doi

10.1016/j.smim.2017.04.003

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

3-13

eissn

1044-5323

issn

1096-3618

pii

S1044-5323(16)30086-0

journal_volume

32

pub_type

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