Abstract:
:The mucosal surfaces of the lungs are a major portal of entry for virus infections and there are urgent needs for new vaccines that promote effective pulmonary immunity. However, we have only a rudimentary understanding of the requirements for effective cellular immunity in the respiratory tract. Recent studies have revealed that specialized cellular immune responses and lymphoid tissues are involved in the protection of distinct anatomical microenvironments of the respiratory tract, such as the large airways of the nose and the alveolar airspaces. This review discusses some of the anatomical features of anti-viral immunity in the respiratory tract including the role of local lymphoid tissues and the relationship between effector and memory T cells in the airways, the lung parenchyma, and lymphoid organs.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Woodland DL,Randall TDdoi
10.1016/j.smim.2004.02.003keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
163-70issue
3eissn
1044-5323issn
1096-3618pii
S104453230400020Xjournal_volume
16pub_type
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