Structure and signalling functions of C3 receptors on human B cells.

Abstract:

:CR1 (C3b receptor) and CR2 (C3d/EBV receptor) are two C3 receptors expressed on B lymphocytes. CR1 and CR2 have structural similarities and their cross-linking at the B cell surface by antibodies or specific ligands in multimeric forms induce B cell activation. However, activation of human B cells through cell surface interactions or by intracellular protein kinase C activators leads to phosphorylation of CR2 but not CR1. CR2 is phosphorylated on serine and tyrosine residues. Analysis of post-membrane events associated with CR2 revealed intracellular interactions of CR2 with p53, a plasma membrane anti-oncogene-encoded phosphoprotein, and with p120, a nuclear phosphoribonucleoprotein. These intracellular interactions probably represent important steps in the signalling functions of CR2.

journal_name

Semin Immunol

journal_title

Seminars in immunology

authors

Frade R

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

159-64

issue

2

eissn

1044-5323

issn

1096-3618

journal_volume

2

pub_type

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