Abstract:
:Metazoan parasites typically induce a type 2 immune response, characterized by T helper 2 (Th2) cells that produce the cytokines IL-4, IL-5 and IL-13 among others. The type 2 response is host protective, reducing the number of parasites either through direct killing in the tissues, or expulsion from the intestine. Type 2 immunity also protects the host against damage mediated by these large extracellular parasites as they migrate through the body. At the center of both the innate and adaptive type 2 immune response, is the IL-4Rα that mediates many of the key effector functions. Here we highlight the striking overlap between the molecules, cells and pathways that mediate both parasite control and tissue repair. We have proposed that adaptive Th2 immunity evolved out of our innate repair pathways to mediate both accelerated repair and parasite control in the face of continual assault from multicellular pathogens. Type 2 cytokines are involved in many aspects of mammalian physiology independent of helminth infection. Therefore understanding the evolutionary relationship between helminth killing and tissue repair should provide new insight into immune mechanisms of tissue protection in the face of physical injury.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Allen JE,Sutherland TEdoi
10.1016/j.smim.2014.06.003subject
Has Abstractpub_date
2014-08-01 00:00:00pages
329-40issue
4eissn
1044-5323issn
1096-3618pii
S1044-5323(14)00060-8journal_volume
26pub_type
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in immunology
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更新日期:2015-08-01 00:00:00
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journal_title:Seminars in immunology
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更新日期:2019-06-01 00:00:00
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journal_title:Seminars in immunology
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doi:10.1016/j.smim.2019.04.003
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2018.02.011
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pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1990-03-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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