Abstract:
:The BLyS family of receptors includes two cytokines, BLyS and APRIL; and three receptors, BR3, BCMA and TACI. Together, these regulate the size and composition of peripheral B cell pools. The multiplicity of ligand-receptor sets, in conjunction with differential receptor expression, alternative binding partners and disparate downstream signaling characteristics, affords the potential to establish independently regulated homeostatic niches among primary and antigen-experienced B cell subsets. Thus, BLyS signaling via BR3 is the dominant homeostatic regulator of primary B cell pools, whereas APRIL interactions with BCMA likely govern memory B cell populations. Short-lived antibody forming cell populations and their proliferating progenitors express a TACI-predominant signature. Further, within each niche, relative fitness to compete for available cytokine is determined by exogenous inputs via adaptive and innate receptor systems, affording intramural hierarchies that determine clonotype composition.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Treml LS,Crowley JE,Cancro MPdoi
10.1016/j.smim.2006.07.001subject
Has Abstractpub_date
2006-10-01 00:00:00pages
297-304issue
5eissn
1044-5323issn
1096-3618pii
S1044-5323(06)00077-7journal_volume
18pub_type
杂志文章,评审abstract::In the adult thymus the majority of thymocytes are at a non-proliferating end stage, during which 3% of all CD4+CD8+ cortical thymocytes are selected on the basis of appropriate T-cell antigen-receptor (TcR) specificity to become CD4-CD8+ or CD4+CD8- mature thymocytes. The selected mature cells gradually emigrate to t...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1990-01-01 00:00:00
abstract::Heterogeneity in the supramolecular organization of immunological synapses arises from the involvement of different cells, distinct environmental stimuli, and varying levels of protein expression. There may also be heterogeneity in the types and amounts of cell surface proteins and lipids that transfer between lymphoc...
journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2018.10.009
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2001-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2015.03.008
更新日期:2015-03-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1990-03-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2017.12.003
更新日期:2018-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.01.001
更新日期:2009-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1998.0137
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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abstract::Ten seven-transmembrane-domain G protein-coupled receptors have been identified that are functional HIV-1, HIV-2 and SIV coreceptors. However, the specific structures these receptors have in common that enable them to mediate HIV entry are unknown. Structure-function analyses have revealed that the determinants of cor...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:1998-06-01 00:00:00
abstract::Cellular activation is mainly defined as the response of a cell to exogenous signals eventually leading to changes in protein expression and cellular function. Originally, macrophage activation was mainly associated with phagocytic function. Later other effector functions such as cytokine secretion, upregulation of ce...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00