Abstract：
:Minor lymphocyte stimulating (Mls) antigens have profound effects on the murine immune system and have been very important for our current understanding of immune tolerance. It has recently been discovered that these Mls antigens are encoded in an open reading frame located in the 3' long terminal repeat of endogenous and infectious mouse mammary tumor viruses (MMTV). In this review we will discuss the effects of a novel infectious MMTV with properties of Mls-1a on the neonatal and adult immune system in comparison to the effects of endogenous Mtv-7 (Mls-1a).
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Acha-Orbea H,Waanders GA,Shakhov AN,Held Wkeywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
297-303issue
5eissn
1044-5323issn
1096-3618journal_volume
4pub_type
杂志文章,评审abstract：:The mammalian alimentary tract harbors hundreds of bacterial species that constitute the indigenous microbial flora. The indigenous microbial flora has long been appreciated for its role in host immune system development. Recent reports suggest that components of the microbial flora differentially affect the proportio...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2011.01.010
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abstract：:The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune home...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2011.01.006
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abstract：:Several studies have demonstrated how different cell types of mesenchymal and myeloid origin can independently exhibit immunoregulatory activities. In response to inflammatory cues, they transcribe a molecular repertoire that restores the tissue microenvironment to what it was before the injury. There is accumulating ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2018.01.002
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abstract：:Ten seven-transmembrane-domain G protein-coupled receptors have been identified that are functional HIV-1, HIV-2 and SIV coreceptors. However, the specific structures these receptors have in common that enable them to mediate HIV entry are unknown. Structure-function analyses have revealed that the determinants of cor...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1998.0130
更新日期：1998-06-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2008.07.001
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abstract：:Despite the overwhelming success of immunization in reducing, and even eliminating, the global threats posed by a wide spectrum of infectious diseases, attempts to do the same for tuberculosis (TB) have failed to date. While most effective vaccines act by eliciting neutralizing antibodies, T cells are the primary medi...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2014.10.003
更新日期：2014-12-01 00:00:00
abstract：:The Ly49 and Nkrp1 loci encode structurally and functionally related cell surface proteins that positively or negatively regulate natural killer (NK) cell-mediated cytotoxicity and cytokine production. Yet despite their clear relatedness and genetic linkage within the NK gene complex (NKC), these two multi-gene famili...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunology
pub_type： 评论,杂志文章,评审
doi：10.1006/smim.1999.0192
更新日期：1999-10-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2014.09.003
更新日期：2014-12-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2018-10-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.2001.0331
更新日期：2001-12-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2000-02-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：:Metazoan parasites typically induce a type 2 immune response, characterized by T helper 2 (Th2) cells that produce the cytokines IL-4, IL-5 and IL-13 among others. The type 2 response is host protective, reducing the number of parasites either through direct killing in the tissues, or expulsion from the intestine. Typ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2014.06.003
更新日期：2014-08-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1991-03-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:Naturally arising CD4(+) regulatory T cells are critical mediators of peripheral self tolerance and immune homeostasis. Emerging evidence suggests that these cells are a dedicated T cell lineage constitutively acting in a dominant, cell extrinsic manner to regulate immune function. These observations are driving a ree...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2003.12.002
更新日期：2004-04-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2009-08-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2018-12-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1994.1037
更新日期：1994-10-01 00:00:00
abstract：:Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversit...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2015-12-01 00:00:00
abstract：:Ectodysplasin (Eda) is the most studied tumor necrosis ligand in the field of developmental biology. In all vertebrates studied so far, inactivating germline mutations in Eda lead to the genetic disease called hypohidrotic ectodermal dysplasia (HED). In humans, HED is a life-threatening condition in particular in infa...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2014-06-01 00:00:00
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2018.05.001
更新日期：2018-10-01 00:00:00
abstract：:The humoral arm of the immune system provides robust protection against extracellular pathogens via the production of antibody molecules that neutralize or facilitate the destruction of microorganisms. However, the humoral immune system also provides a significant barrier to solid organ transplantation due to the anti...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2011-08-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co-opt MSCs and re-program their functional profile from normally trophic to pro-tumorigenic. These tumor-derived small vesicles called "TEX" carry and ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.12.003
更新日期：2018-02-01 00:00:00
abstract：:Cellular activation is mainly defined as the response of a cell to exogenous signals eventually leading to changes in protein expression and cellular function. Originally, macrophage activation was mainly associated with phagocytic function. Later other effector functions such as cytokine secretion, upregulation of ce...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
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更新日期：2015-12-01 00:00:00
abstract：:Plasmacytoid dendritic cells (pDCs) are specialized sensors of viral nucleic acids that initiate protective immunity through the production of type I interferons (IFNs). Normally, pDCs fail to sense host-derived self-nucleic acids but do so when self-nucleic acids form complexes with endogenous antimicrobial peptides ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2009.01.004
更新日期：2009-06-01 00:00:00
