Harnessing dendritic cells in inflammatory skin diseases.

abstract：:Most cells in the body have a constant supply of nutrients, which are required to sustain cellular metabolism and functions. In contrast, cells of the immune system can encounter conditions with a limited nutrient supply during the course of an immune response. Cells of the immune system frequently operate in complex ...

journal_title：Seminars in immunology

authors： Walls J,Sinclair L,Finlay D

更新日期：2016-10-01 00:00:00

abstract：:The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in the tumor environment and is strictly regulated on lymphocytes such ...

journal_title：Seminars in immunology

authors： Kim WM,Huang YH,Gandhi A,Blumberg RS

更新日期：2019-04-01 00:00:00

abstract：:Alarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity. HMGB1 serves a dual alarmin function. The protein can be emitted to alert...

journal_title：Seminars in immunology

authors： Andersson U,Yang H,Harris H

更新日期：2018-08-01 00:00:00

abstract：:Naturally arising CD4(+) regulatory T cells are critical mediators of peripheral self tolerance and immune homeostasis. Emerging evidence suggests that these cells are a dedicated T cell lineage constitutively acting in a dominant, cell extrinsic manner to regulate immune function. These observations are driving a ree...

journal_title：Seminars in immunology

authors： Fontenot JD,Rudensky AY

更新日期：2004-04-01 00:00:00

abstract：:Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversit...

journal_title：Seminars in immunology

authors： Kierdorf K,Prinz M,Geissmann F,Gomez Perdiguero E

更新日期：2015-12-01 00:00:00

abstract：:In the adult thymus the majority of thymocytes are at a non-proliferating end stage, during which 3% of all CD4+CD8+ cortical thymocytes are selected on the basis of appropriate T-cell antigen-receptor (TcR) specificity to become CD4-CD8+ or CD4+CD8- mature thymocytes. The selected mature cells gradually emigrate to t...

journal_title：Seminars in immunology

authors： Shortman K,Egerton M,Spangrude GJ,Scollay R

更新日期：1990-01-01 00:00:00

abstract：:Follicular dendritic cells (FDCs) have important functions in the selection of memory B lymphocytes during germinal center reactions (GCR). They present native antigens to potential memory cells, of which only B cells with high affinity B cell receptors (BCR) can bind. These B lymphocytes survive, whereas nonbinding B...

journal_title：Seminars in immunology

authors： van Nierop K,de Groot C

更新日期：2002-08-01 00:00:00

abstract：:The pursuit of clinical transplant tolerance has led to enhanced understanding of mechanisms underlying immune regulation, including the characterization of immune regulatory cells, in particular antigen-presenting cells (APC) and regulatory T cells (Treg), that may play key roles in promoting operational tolerance. D...

journal_title：Seminars in immunology

authors： Ezzelarab M,Thomson AW

更新日期：2011-08-01 00:00:00

abstract：:Studies on oral immunotherapy (OIT) have been increasing worldwide. Nevertheless, some concerns exist with this treatment. The rate of long-term sustained unresponsiveness is quite low; moreover, the desensitization or sustained unresponsiveness does not equate to tolerance. Furthermore, adverse reactions are frequent...

journal_title：Seminars in immunology

authors： Yanagida N,Sato S,Ebisawa M

更新日期：2017-04-01 00:00:00

abstract：:The commensal microbiome constitutes an important modulator of host physiology and risk of disease, including cancer development and progression. Lately, the microbiome has been suggested to modulate the efficacy of anti-cancer treatment. Examples include chemotherapy and total body irradiation-induced barrier functio...

journal_title：Seminars in immunology

authors： Bashiardes S,Tuganbaev T,Federici S,Elinav E

更新日期：2017-08-01 00:00:00

abstract：:The mechanisms by which alphabeta T-cells are selected in the thymus and then recognize peptide MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with respect to quantification of T-cell sensitivity and the role of self-ligands in T-cell activation has provided some important clues to th...

journal_title：Seminars in immunology

authors： Krogsgaard M,Juang J,Davis MM

更新日期：2007-08-01 00:00:00

abstract：:The complement system covalently attaches C3d to microbial antigens which binds to CR2 on B lymphocytes, leading to a markedly enhanced adaptive immune response to that antigen. The enhancement is mediated by the cross-linking of the CR2-CD19 complex to mIg which augments the activation of several intracellular signal...

journal_title：Seminars in immunology

authors： Fearon DT

更新日期：1998-10-01 00:00:00

abstract：:Viral and microbial pathogens contain specific motifs or pathogen-associated molecular patterns (PAMPs) that are recognized by cell surface- and endosome-associated Toll-like receptors (TLRs). RNA virus infection is also detected through TLR-independent mechanisms. Early viral replicative intermediates are detected by...

journal_title：Seminars in immunology

authors： Nakhaei P,Genin P,Civas A,Hiscott J

更新日期：2009-08-01 00:00:00

abstract：:Mendelian susceptibility to mycobacterial diseases confers predisposition to clinical disease caused by weakly virulent mycobacterial species in otherwise healthy individuals. Since 1996, disease-causing mutations have been found in five autosomal genes (IFNGR1, IFNGR2, STAT1, IL12B, IL12BR1) and one X-linked gene (NE...

journal_title：Seminars in immunology

authors： Filipe-Santos O,Bustamante J,Chapgier A,Vogt G,de Beaucoudrey L,Feinberg J,Jouanguy E,Boisson-Dupuis S,Fieschi C,Picard C,Casanova JL

更新日期：2006-12-01 00:00:00

abstract：:No abstractCopyright 1997 Academic Press Limited Copyright 1997Academic Press Limited ...

journal_title：Seminars in immunology

authors： Scollay R,Sprent J

更新日期：1997-12-01 00:00:00

abstract：:A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available f...

journal_title：Seminars in immunology

authors： Kobayashi M,Katayama H,Fahrmann JF,Hanash SM

更新日期：2020-02-01 00:00:00

abstract：:Ten seven-transmembrane-domain G protein-coupled receptors have been identified that are functional HIV-1, HIV-2 and SIV coreceptors. However, the specific structures these receptors have in common that enable them to mediate HIV entry are unknown. Structure-function analyses have revealed that the determinants of cor...

journal_title：Seminars in immunology

authors： Berson JF,Doms RW

更新日期：1998-06-01 00:00:00

abstract：:Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory, metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but metabolically active cells that can secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype (...

journal_title：Seminars in immunology

authors： Prata LGPL,Ovsyannikova IG,Tchkonia T,Kirkland JL

更新日期：2018-12-01 00:00:00

abstract：:The recombination activating genes 1 and 2 (Rag1 and Rag2) encode the key enzyme that is required for the generation of the highly diversified antigen receptor repertoire central to adaptive immunity. The longstanding model proposed that this gene pair was acquired by horizontal gene transfer to explain its abrupt app...

journal_title：Seminars in immunology

authors： Fugmann SD

更新日期：2010-02-01 00:00:00

abstract：:A novel lymphocyte lineage, V alpha 14 NKT cells, has recently been identified and appears to be distinct from conventional alphabeta T cells. V alpha 14 NKT cells express a single invariant V alpha 14 antigen receptor that is essential for their development. They recognize a glycolipid antigen (alpha -galactosylceram...

journal_title：Seminars in immunology

authors： Taniguchi M,Nakayama T

更新日期：2000-12-01 00:00:00

abstract：:Multiple monoclonal and polyclonal antibody preparations have been shown to neutralize HIV-1 infection in vitro. Upon direct testing in humans, however, many of these have failed to demonstrate clinical efficacy. Hu-PBL-SCID mice offer a model system in which to test the pre-clinical efficacy of antibody preparations....

journal_title：Seminars in immunology

authors： Koup RA,Safrit JT,Weir R,Gauduin MC

更新日期：1996-08-01 00:00:00

abstract：:Immune receptors are coupled to the activation of phosphatidylcholine phospholipase D (PC-PLD) that hydrolyses phosphatidylcholine to generate phosphatidic acid and choline. As these receptors are also coupled to other signalling cascades, it has been difficult to define the precise cell activation events resulting fr...

journal_title：Seminars in immunology

authors： Melendez AJ,Allen JM

更新日期：2002-02-01 00:00:00

abstract：:Antibody production is crucial for a successful vaccine response. Beyond the ability of vitamin A (VA) and its active metabolite, all-trans-retinoic acid (RA) to restore growth in VA-deficient animals, supplementation with VA and/or treatment with RA can augment antibody responses in both VA-deficient and VA-adequate ...

journal_title：Seminars in immunology

authors： Ross AC,Chen Q,Ma Y

更新日期：2009-02-01 00:00:00

abstract：:The OX-40 receptor (OX-40R) is a transmembrane protein found on the surface of activated CD4(+) T cells. When engaged by an agonist such as anti-OX-40 antibody or the OX-40 ligand (OX-40L) during antigen presentation to T cell lines, the OX-40R generates a costimulatory signal that is as potent as CD28 costimulation. ...

journal_title：Seminars in immunology

authors： Weinberg AD,Vella AT,Croft M

更新日期：1998-12-01 00:00:00

abstract：:A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its pro...

journal_title：Seminars in immunology

authors： Nardini C,Moreau JF,Gensous N,Ravaioli F,Garagnani P,Bacalini MG

更新日期：2018-12-01 00:00:00

abstract：:After decades of slow progress, the last years have seen a rapid acceleration of the development of adjuvanted vaccines which have lately been approved for human use. These adjuvants consist of different components, e.g. aluminium salts, emulsions such as MF59 and AS03, Toll-like receptor (TLR) agonists (CpG ormonopho...

journal_title：Seminars in immunology

authors： Del Giudice G,Rappuoli R,Didierlaurent AM

更新日期：2018-10-01 00:00:00

abstract：:Autoimmune diseases have been studied from the perspective of an abnormal immune response in genetically vulnerable hosts. Although the immune response is responsible for the initiation of autoimmune diseases, the effectors of the disease process likely involves cytokines such as interleukin-1 (IL-1) and tumor necrosi...

journal_title：Seminars in immunology

authors： Dinarello CA

更新日期：1992-06-01 00:00:00

abstract：:The unfolded protein response as a consequence of endoplasmic reticulum (ER) stress has recently been implicated as a novel mechanism that may lead to inflammatory bowel disease (IBD). Impairment of proper ER stress resolution in highly secretory Paneth and, to a lesser extent, goblet cells within the epithelium can p...

journal_title：Seminars in immunology

authors： Kaser A,Blumberg RS

更新日期：2009-06-01 00:00:00

abstract：:The signalling mechanisms of the IL-2R remained an enigma until recent years. We now know that IL-2R are coupled to their own unique signalling pathways that complement rather than duplicate TCR signalling. The IL-2R beta- and gamma-chains are essential for signal coupling. Sequence comparisons indicate that portions ...

journal_title：Seminars in immunology

authors： Williamson P,Merida I,Gaulton G

更新日期：1993-10-01 00:00:00

abstract：:Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Reciprocally, uncontrolled immune responses, that may or may not be induced by dysbiosis, are central to the development of IBD and CAC. There has ...

journal_title：Seminars in immunology

authors： Kang M,Martin A

更新日期：2017-08-01 00:00:00