Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features.

abstract：:Many immune cells can detect the direction and intensity of an extracellular chemical gradient, and migrate toward the source of stimulus. This process, called chemotaxis, is essential for immune system function and homeostasis, and its deregulation is associated with serious diseases. Chemotaxis is initiated by chemo...

journal_title：Seminars in immunology

authors： Mañes S,Gómez-Moutón C,Lacalle RA,Jiménez-Baranda S,Mira E,Martínez-A C

更新日期：2005-02-01 00:00:00

abstract：:Immune receptors are coupled to the activation of phosphatidylcholine phospholipase D (PC-PLD) that hydrolyses phosphatidylcholine to generate phosphatidic acid and choline. As these receptors are also coupled to other signalling cascades, it has been difficult to define the precise cell activation events resulting fr...

journal_title：Seminars in immunology

authors： Melendez AJ,Allen JM

更新日期：2002-02-01 00:00:00

abstract：:Protein tyrosine phosphatases (PTPs) are a family of enzymes that modulate the cellular level of tyrosine phosphorylation. Based on cellular location, they are classified as receptor like or intracellular PTPs. Structure and function studies have led to the understanding of the enzymatic mechanism of this class of enz...

journal_title：Seminars in immunology

authors： Li L,Dixon JE

更新日期：2000-02-01 00:00:00

abstract：:Interaction of CD40 on B cells with its ligand on activated T helper cells is crucial for the generation of mature T-dependent antibody responses. Experimental observations suggest that CD40 ligation acts at several points in B cell differentiation; however, it is not clear whether the consequences of ligation are dir...

journal_title：Seminars in immunology

authors： Gray D,Siepmann K,Wohlleben G

更新日期：1994-10-01 00:00:00

abstract：:Signals from the precursor-B cell receptor (pre-BCR) are essential for selection and clonal expansion of pre-B cells that have performed productive immunoglobulin heavy chain V(D)J recombination. In the mouse, the downstream signaling molecules SLP-65 and Btk cooperate to limit proliferation and induce differentiation...

journal_title：Seminars in immunology

authors： Hendriks RW,Kersseboom R

更新日期：2006-02-01 00:00:00

abstract：:Obesity is now recognised as a chronic, low-grade inflammatory disease contributing to insulin resistance, type 2 diabetes (T2D) and cardiovascular disease (CVD). Multiple mechanisms leading to the low grade inflammation in this setting have been suggested. Due to the complexity and interconnection of inflammatory and...

journal_title：Seminars in immunology

authors： Lee MK,Yvan-Charvet L,Masters SL,Murphy AJ

更新日期：2016-10-01 00:00:00

abstract：:The unfolded protein response as a consequence of endoplasmic reticulum (ER) stress has recently been implicated as a novel mechanism that may lead to inflammatory bowel disease (IBD). Impairment of proper ER stress resolution in highly secretory Paneth and, to a lesser extent, goblet cells within the epithelium can p...

journal_title：Seminars in immunology

authors： Kaser A,Blumberg RS

更新日期：2009-06-01 00:00:00

abstract：:Toll-like receptors are a family of pattern recognition receptors (PRRs) that evolved to detect microbial infection. These receptors recognize conserved molecular products derived from different classes of microorganisms, including Gram-positive and -negative bacteria, fungi, protozoa and viruses. Following recognitio...

journal_title：Seminars in immunology

authors： Pasare C,Medzhitov R

更新日期：2004-02-01 00:00:00

abstract：:Several studies have demonstrated how different cell types of mesenchymal and myeloid origin can independently exhibit immunoregulatory activities. In response to inflammatory cues, they transcribe a molecular repertoire that restores the tissue microenvironment to what it was before the injury. There is accumulating ...

journal_title：Seminars in immunology

authors： Cheung TS,Dazzi F

更新日期：2018-02-01 00:00:00

abstract：:In the adult thymus the majority of thymocytes are at a non-proliferating end stage, during which 3% of all CD4+CD8+ cortical thymocytes are selected on the basis of appropriate T-cell antigen-receptor (TcR) specificity to become CD4-CD8+ or CD4+CD8- mature thymocytes. The selected mature cells gradually emigrate to t...

journal_title：Seminars in immunology

authors： Shortman K,Egerton M,Spangrude GJ,Scollay R

更新日期：1990-01-01 00:00:00

abstract：:Antibody production is crucial for a successful vaccine response. Beyond the ability of vitamin A (VA) and its active metabolite, all-trans-retinoic acid (RA) to restore growth in VA-deficient animals, supplementation with VA and/or treatment with RA can augment antibody responses in both VA-deficient and VA-adequate ...

journal_title：Seminars in immunology

authors： Ross AC,Chen Q,Ma Y

更新日期：2009-02-01 00:00:00

abstract：:Foxp3+CD4+ regulatory T (T(reg)) cells are a key population in controlling the immune response. Recently, their roles have been expanded to broader, non-immune, contexts, in particular the metabolic consequences downstream of obesity-induced inflammation, e.g. type-2 diabetes and cardiovascular disease. This review hi...

journal_title：Seminars in immunology

authors： Cipolletta D,Kolodin D,Benoist C,Mathis D

更新日期：2011-12-01 00:00:00

abstract：:Helper T cell activation leads to transient expression of a ligand for the B cell surface protein, CD40. CD40 ligand can deliver helper T cell-derived contact signals to B lymphocytes that drive B cell activation and proliferation. Regulation of expression of CD40 ligand is analogous to that of other helper T cell-der...

journal_title：Seminars in immunology

authors： Kehry MR,Castle BE

更新日期：1994-10-01 00:00:00

abstract：:Recent advances have enabled a comprehensive understanding of the genetic architecture of inflammatory bowel disease (IBD) with over 30 identified and replicated disease loci. The pathophysiological consequences of disease gene variants in Crohn disease and ulcerative colitis, the two main subentities of IBD, so far a...

journal_title：Seminars in immunology

authors： Rosenstiel P,Sina C,Franke A,Schreiber S

更新日期：2009-12-01 00:00:00

abstract：:The OX-40 receptor (OX-40R) is a transmembrane protein found on the surface of activated CD4(+) T cells. When engaged by an agonist such as anti-OX-40 antibody or the OX-40 ligand (OX-40L) during antigen presentation to T cell lines, the OX-40R generates a costimulatory signal that is as potent as CD28 costimulation. ...

journal_title：Seminars in immunology

authors： Weinberg AD,Vella AT,Croft M

更新日期：1998-12-01 00:00:00

abstract：:Recent evidence indicates that memory B cells may originate from a precursor cell subset that is distinct from AFC precursors. Most convincing is the finding that fractionation of naive peripheral B-cell populations on the basis of surface heat stable antigen (HSA) expression yields two populations; one greatly enrich...

journal_title：Seminars in immunology

authors： Klinman NR

更新日期：1997-08-01 00:00:00

abstract：:The commensal microbiome constitutes an important modulator of host physiology and risk of disease, including cancer development and progression. Lately, the microbiome has been suggested to modulate the efficacy of anti-cancer treatment. Examples include chemotherapy and total body irradiation-induced barrier functio...

journal_title：Seminars in immunology

authors： Bashiardes S,Tuganbaev T,Federici S,Elinav E

更新日期：2017-08-01 00:00:00

abstract：:TCR gamma delta + T cells represent a minority of CD3+ T cells in many species including man. The molecular structure of the TCR gamma and delta loci in man is well understood. The gamma and delta loci contain V, D, J and C gene segments. These segments do not rearrange randomly but in a coordinated, ordered fashion d...

journal_title：Seminars in immunology

authors： Spits H

更新日期：1991-03-01 00:00:00

abstract：:In humans, blood is commonly monitored to provide surrogates of disease progression and assess immune status. However, the varied, rapid and atypical alterations in lymphocyte subsets which may occur in blood in response to pathogens, are not predictive of changes in the bulk of the immune system. A hallmark of human ...

journal_title：Seminars in immunology

authors： Rosenberg YJ,Janossy G

更新日期：1999-04-01 00:00:00

abstract：:Despite the overwhelming success of immunization in reducing, and even eliminating, the global threats posed by a wide spectrum of infectious diseases, attempts to do the same for tuberculosis (TB) have failed to date. While most effective vaccines act by eliciting neutralizing antibodies, T cells are the primary medi...

journal_title：Seminars in immunology

authors： Urdahl KB

更新日期：2014-12-01 00:00:00

abstract：:Department of lymphocytes from hematopoietic stem cells is controlled, in part, by the activity of transcriptional regulatory proteins. In particular, one class of helix-loop-helix proteins, termed E-proteins, have been implicated in the regulation of gene expression during B-cell development. Recent analysis of gene-...

journal_title：Seminars in immunology

authors： Bain G,Murre C

更新日期：1998-04-01 00:00:00

abstract：:Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is required to allow mouse embryo survival, and the survival of hematopoietic cells during their development and activation. Cla...

journal_title：Seminars in immunology

authors： Salvesen GS,Walsh CM

更新日期：2014-06-01 00:00:00

abstract：:Leukocyte subsets are recruited from the blood to lymphoid and non-lymphoid tissues via a multi-step process that involves distinct adhesive and activation steps. Chemokines, a family of chemotactic cytokines that signal through G-protein-coupled receptors, play critical roles in regulating the leukocyte recruitment c...

journal_title：Seminars in immunology

authors： Johnston B,Butcher EC

更新日期：2002-04-01 00:00:00

abstract：:The signalling mechanisms of the IL-2R remained an enigma until recent years. We now know that IL-2R are coupled to their own unique signalling pathways that complement rather than duplicate TCR signalling. The IL-2R beta- and gamma-chains are essential for signal coupling. Sequence comparisons indicate that portions ...

journal_title：Seminars in immunology

authors： Williamson P,Merida I,Gaulton G

更新日期：1993-10-01 00:00:00

abstract：:Multiple sclerosis (MS) is an idiopathic autoimmune neurodegenerative disease. Like many common diseases, MS has a genetic component; however, as with most complex diseases, the genetic architecture may be influenced by heterogeneity, incomplete penetrance, polygenic inheritance, and environmental factors. This clinic...

journal_title：Seminars in immunology

authors： Zuvich RL,McCauley JL,Pericak-Vance MA,Haines JL

更新日期：2009-12-01 00:00:00

abstract：:Ten seven-transmembrane-domain G protein-coupled receptors have been identified that are functional HIV-1, HIV-2 and SIV coreceptors. However, the specific structures these receptors have in common that enable them to mediate HIV entry are unknown. Structure-function analyses have revealed that the determinants of cor...

journal_title：Seminars in immunology

authors： Berson JF,Doms RW

更新日期：1998-06-01 00:00:00

abstract：:CR1 (C3b receptor) and CR2 (C3d/EBV receptor) are two C3 receptors expressed on B lymphocytes. CR1 and CR2 have structural similarities and their cross-linking at the B cell surface by antibodies or specific ligands in multimeric forms induce B cell activation. However, activation of human B cells through cell surface...

journal_title：Seminars in immunology

authors： Frade R

更新日期：1990-03-01 00:00:00

abstract：:The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in the tumor environment and is strictly regulated on lymphocytes such ...

journal_title：Seminars in immunology

authors： Kim WM,Huang YH,Gandhi A,Blumberg RS

更新日期：2019-04-01 00:00:00

abstract：:Interleukin-2 (IL-2) is a growth and differentiation factor critical for clonal T cell expansion and function. Produced exclusively in T cells, IL-2 transcription and synthesis occurs only after appropriate cellular activation via the clonotypic antigen-receptor and co-stimulatory molecules. IL-2 gene expression is in...

journal_title：Seminars in immunology

authors： Holländer GA

更新日期：1999-10-01 00:00:00

abstract：:Natural killer (NK) cells have traditionally been classified as a cellular component of the innate immune system, given their ability to rapidly produce effector cytokines and kill infected or transformed cells without prior exposure. More recently, NK cells have been shown to possess features of adaptive immunity suc...

journal_title：Seminars in immunology

authors： Geary CD,Sun JC

更新日期：2017-06-01 00:00:00