Abstract：
:Department of lymphocytes from hematopoietic stem cells is controlled, in part, by the activity of transcriptional regulatory proteins. In particular, one class of helix-loop-helix proteins, termed E-proteins, have been implicated in the regulation of gene expression during B-cell development. Recent analysis of gene-targeted mice has allowed a direct assessment of the functional roles of several E-protein family members in hematopoiesis. In this review we describe the defects in B- and T-lymphocyte development in mice carrying targeted mutations in the E-protein genes and discuss our current understanding of the role of these proteins in lymphoid development.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Bain G,Murre Cdoi
10.1006/smim.1998.0116subject
Has Abstractpub_date
1998-04-01 00:00:00pages
143-53issue
2eissn
1044-5323issn
1096-3618pii
S1044-5323(98)90116-6journal_volume
10pub_type
杂志文章,评审abstract：:Macrophages are unique cells for origin, heterogeneity and plasticity. At steady state most of macrophages are derived from fetal sources and maintained in adulthood through self-renewing. Despite sharing common progenitors, a remarkable heterogeneity characterized tissue-resident macrophages indicating that local sig...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2015.10.003
更新日期：2015-08-01 00:00:00
abstract：:This issue of Seminars in Immunology on The Interleukin-1 (IL-1) Family of Ligands and Receptors updates the rapidly expanding importance of this family. There are individual chapters on IL-1α, IL-1β, processing and secretion of IL-1β, IL-18, IL-33, IL-36 and IL-37. In addition, a chapter of IL-1 decoy receptors, IL-1...
journal_title：Seminars in immunology
pub_type： 社论
doi：10.1016/j.smim.2013.10.001
更新日期：2013-12-15 00:00:00
abstract：:The creation of a highly diverse antibody repertoire requires the synergistic activity of a DNA mutator, known as activation-induced deaminase (AID), coupled with an error-prone repair process that recognizes the DNA mismatch catalyzed by AID. Instead of facilitating the canonical error-free response, which generally ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2012.05.005
更新日期：2012-08-01 00:00:00
abstract：:T helper 17 (Th17) cells have been reported to be responsible for several chronic inflammatory diseases. However, a peculiar feature of human Th17 cells is that they are very rare in the inflammatory sites in comparison with Th1 cells. The first reason for this rarity is the existence of some self-regulatory mechanism...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2013.10.011
更新日期：2013-11-15 00:00:00
abstract：:Apoptosis of activated lymphocytes is critical to immune homeostasis. The cell surface receptor Fas is an important mediator of lymphocyte apoptosis; defective Fas expression causes accumulation of lymphocytes and autoimmune disease in mice. Apoptosis defects due to mutations of Fas have also been found in a rare huma...
journal_title：Seminars in immunology
pub_type： 杂志文章
doi：10.1006/smim.1996.0056
更新日期：1997-02-01 00:00:00
abstract：:The commensal microbiome constitutes an important modulator of host physiology and risk of disease, including cancer development and progression. Lately, the microbiome has been suggested to modulate the efficacy of anti-cancer treatment. Examples include chemotherapy and total body irradiation-induced barrier functio...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.04.001
更新日期：2017-08-01 00:00:00
abstract：:Mendelian susceptibility to mycobacterial diseases confers predisposition to clinical disease caused by weakly virulent mycobacterial species in otherwise healthy individuals. Since 1996, disease-causing mutations have been found in five autosomal genes (IFNGR1, IFNGR2, STAT1, IL12B, IL12BR1) and one X-linked gene (NE...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2006.07.010
更新日期：2006-12-01 00:00:00
abstract：:Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory, metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but metabolically active cells that can secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype (...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2019.04.003
更新日期：2018-12-01 00:00:00
abstract：:Heavy chain class-switching is the process by which B lymphoid cells change the constant region of the immunoglobulin heavy chain they produce. Class-switching is most commonly accomplished by recombinationldeletion between switch recombination regions that lie upstream of each germline heavy chain constant region gen...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：:The recombination activating genes 1 and 2 (Rag1 and Rag2) encode the key enzyme that is required for the generation of the highly diversified antigen receptor repertoire central to adaptive immunity. The longstanding model proposed that this gene pair was acquired by horizontal gene transfer to explain its abrupt app...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2009.11.004
更新日期：2010-02-01 00:00:00
abstract：:In the adult thymus the majority of thymocytes are at a non-proliferating end stage, during which 3% of all CD4+CD8+ cortical thymocytes are selected on the basis of appropriate T-cell antigen-receptor (TcR) specificity to become CD4-CD8+ or CD4+CD8- mature thymocytes. The selected mature cells gradually emigrate to t...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:Viral and microbial pathogens contain specific motifs or pathogen-associated molecular patterns (PAMPs) that are recognized by cell surface- and endosome-associated Toll-like receptors (TLRs). RNA virus infection is also detected through TLR-independent mechanisms. Early viral replicative intermediates are detected by...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2009.05.001
更新日期：2009-08-01 00:00:00
abstract：:The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune home...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2011.01.006
更新日期：2011-02-01 00:00:00
abstract：:Natural killer (NK) cells have traditionally been classified as a cellular component of the innate immune system, given their ability to rapidly produce effector cytokines and kill infected or transformed cells without prior exposure. More recently, NK cells have been shown to possess features of adaptive immunity suc...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.08.012
更新日期：2017-06-01 00:00:00
abstract：:Follicular dendritic cells (FDCs) were identified decades ago by their ability to retain immune complexes and more recent findings indicate that they are a source of B cell attractants and trophic factors. New imaging studies have shown that B cells closely associate with their dendritic processes during migration. He...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2007.12.001
更新日期：2008-02-01 00:00:00
abstract：:Interferon epsilon (IFNε) is a type I IFN with unusual patterns of expression and therefore, function. It is constitutively expressed by reproductive tract epithelium and regulated by hormones during estrus cycle, reproduction, and menopause and by exogenous hormones. The IFNe protein is encoded by a gene in the type ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2019.101328
更新日期：2019-06-01 00:00:00
abstract：:Several studies have demonstrated how different cell types of mesenchymal and myeloid origin can independently exhibit immunoregulatory activities. In response to inflammatory cues, they transcribe a molecular repertoire that restores the tissue microenvironment to what it was before the injury. There is accumulating ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2018.01.002
更新日期：2018-02-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co-opt MSCs and re-program their functional profile from normally trophic to pro-tumorigenic. These tumor-derived small vesicles called "TEX" carry and ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.12.003
更新日期：2018-02-01 00:00:00
abstract：:Follicular dendritic cells (FDCs) have important functions in the selection of memory B lymphocytes during germinal center reactions (GCR). They present native antigens to potential memory cells, of which only B cells with high affinity B cell receptors (BCR) can bind. These B lymphocytes survive, whereas nonbinding B...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1044-5323(02)00057-x
更新日期：2002-08-01 00:00:00
abstract：:Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Reciprocally, uncontrolled immune responses, that may or may not be induced by dysbiosis, are central to the development of IBD and CAC. There has ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.04.003
更新日期：2017-08-01 00:00:00
abstract：:CR1 (C3b receptor) and CR2 (C3d/EBV receptor) are two C3 receptors expressed on B lymphocytes. CR1 and CR2 have structural similarities and their cross-linking at the B cell surface by antibodies or specific ligands in multimeric forms induce B cell activation. However, activation of human B cells through cell surface...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1990-03-01 00:00:00
abstract：:Nanotechnology-based strategies can dramatically impact the treatment, prevention and diagnosis of a wide range of diseases. Despite the unprecedented success achieved with the use of nanomaterials to address unmet biomedical needs and their particular suitability for the effective application of a personalized medici...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.09.003
更新日期：2017-12-01 00:00:00
abstract：:The identification of the common lymphoid progenitors in mouse bone marrow allows us to directly assess the regulatory mechanisms of lymphoid lineage commitment. The unexpected finding of a latent myeloid differentiation potential in lymphoid progenitors sheds light on the importance of cytokine receptor expression at...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1044532302000726
更新日期：2002-12-01 00:00:00
abstract：:CD4+ helper T cells recognize short peptides stably associated with class II MHC molecules displayed on the surface of antigen presenting cells. Very little is known about the sequence of events that lead to the generation of these peptides from protein antigens. It is likely that native proteins must partially unfold...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1995.0039
更新日期：1995-12-01 00:00:00
abstract：:As T cells respond to pathogens, they must transition from a quiescent, naïve state, to a rapidly proliferating, active effector state, and back again to a quiescent state as they develop into memory cells. Such transitions place unique metabolic demands on the differentiating cells. T cells meet these demands by alte...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2012.12.006
更新日期：2012-12-01 00:00:00
abstract：:Leukocyte subsets are recruited from the blood to lymphoid and non-lymphoid tissues via a multi-step process that involves distinct adhesive and activation steps. Chemokines, a family of chemotactic cytokines that signal through G-protein-coupled receptors, play critical roles in regulating the leukocyte recruitment c...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.2001.0345
更新日期：2002-04-01 00:00:00
abstract：:The signalling mechanisms of the IL-2R remained an enigma until recent years. We now know that IL-2R are coupled to their own unique signalling pathways that complement rather than duplicate TCR signalling. The IL-2R beta- and gamma-chains are essential for signal coupling. Sequence comparisons indicate that portions ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1993.1040
更新日期：1993-10-01 00:00:00
abstract：:Interleukin-2 (IL-2) is a growth and differentiation factor critical for clonal T cell expansion and function. Produced exclusively in T cells, IL-2 transcription and synthesis occurs only after appropriate cellular activation via the clonotypic antigen-receptor and co-stimulatory molecules. IL-2 gene expression is in...
journal_title：Seminars in immunology
pub_type： 评论,杂志文章,评审
doi：10.1006/smim.1999.0192
更新日期：1999-10-01 00:00:00
abstract：:Metazoan parasites typically induce a type 2 immune response, characterized by T helper 2 (Th2) cells that produce the cytokines IL-4, IL-5 and IL-13 among others. The type 2 response is host protective, reducing the number of parasites either through direct killing in the tissues, or expulsion from the intestine. Typ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2014.06.003
更新日期：2014-08-01 00:00:00
abstract：:Foxp3+CD4+ regulatory T (T(reg)) cells are a key population in controlling the immune response. Recently, their roles have been expanded to broader, non-immune, contexts, in particular the metabolic consequences downstream of obesity-induced inflammation, e.g. type-2 diabetes and cardiovascular disease. This review hi...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2011.06.002
更新日期：2011-12-01 00:00:00
