Abstract：
:Apoptosis of activated lymphocytes is critical to immune homeostasis. The cell surface receptor Fas is an important mediator of lymphocyte apoptosis; defective Fas expression causes accumulation of lymphocytes and autoimmune disease in mice. Apoptosis defects due to mutations of Fas have also been found in a rare human autoimmune lymphoproliferative syndrome (ALPS). Nine unrelated children with ALPS had lymphadenopathy, autoimmunity and expansion of a normally infrequent population of CD4-CD8-T cells. All nine exhibited impaired lymphocyte apoptosis in vitro, and eight had heterozygous Fas gene mutations. Thus genetic defects in apoptosis pathways are implicated in the pathogenesis of at least one human autoimmune disorder.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Puck JM,Sneller MCdoi
10.1006/smim.1996.0056subject
Has Abstractpub_date
1997-02-01 00:00:00pages
77-84issue
1eissn
1044-5323issn
1096-3618pii
S1044-5323(96)90056-1journal_volume
9pub_type
杂志文章abstract：:Conventional therapies for malignant gliomas (MGs) fail to target tumor cells exclusively, such that their efficacy is ultimately limited by non-specific toxicity. Immunologic targeting of tumor-specific gene mutations, however, may allow more precise eradication of neoplastic cells. The epidermal growth factor recept...
journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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