Abstract:
:Major histocompatibility complex (MHC) class II molecules display peptides to the T cell receptor (TCR). The ability of the TCR to discriminate foreign from self-peptides presented by MHC molecules is a requirement of an effective adaptive immune response. Dysregulation of this molecular recognition event often leads to a disease state. Recently, a number of structural studies have provided significant insight into several such dysregulated interactions between peptide/MHC complexes and TCR molecules. These include TCR recognition of self-peptides, which results in autoimmune reactions, and of mutant self-peptides, common in the immunosurveillance of tumors, as well as the engagement of TCRs by superantigens, a family of bacterial toxins responsible for toxic shock syndrome.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Sundberg EJ,Deng L,Mariuzza RAdoi
10.1016/j.smim.2007.04.006subject
Has Abstractpub_date
2007-08-01 00:00:00pages
262-71issue
4eissn
1044-5323issn
1096-3618pii
S1044-5323(07)00060-7journal_volume
19pub_type
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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doi:10.1016/j.smim.2004.08.001
更新日期:2004-08-01 00:00:00
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:1998-04-01 00:00:00
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journal_title:Seminars in immunology
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更新日期:2007-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00