Abl tyrosine protein kinase.

Abstract:

:Mammalian c-Abl belongs to an evolutionary conserved family of non-receptor tyrosine kinases. It is distributed both in the cytoplasm in association with F-actin, and in the nucleus where it binds chromatin. The normal function of c-Abl is poorly understood. Nevertheless, there has been rapid progress in the characterization of the structural features, signal transduction pathways, substrates and ligands involved in the action of c-Abl and Abl-derived oncogenes. These developments suggest that several mechanisms co-operate to allow regulation of normal cell growth by c-Abl and induction of leukemias by Bcr-abl.

journal_name

Semin Immunol

journal_title

Seminars in immunology

authors

Laneuville P

doi

10.1006/smim.1995.0030

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

255-66

issue

4

eissn

1044-5323

issn

1096-3618

pii

S1044-5323(85)70030-9

journal_volume

7

pub_type

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