Abstract:
:In seeking an explanation for the complexity of tissue development, biologists are obliged to explain lineage commitment, the events that dictate whether or not a progenitor cell will differentiate into one cell type or another. Such explanations have been sought across a broad spectrum of biological systems, although in no case has a full under- standing been developed. For immunologists, attention has been focused on the lineage commitment of a T cell progenitor to becoming either a gammadelta T cell or an alphabeta T cell. In this review, we compare the signals that thymocytes may receive from the pre T cell receptor (preTCR) with signalling from TCRgammadelta. These signals may determine, co-determine, facilitate, or cement the alphabeta/gammadelta lineage decision, in concert with signals from additional molecules, such as Notch and cytokine receptors. Elucidating the pleiotropic signalling events, particularly those elicited by the preTCR, may in the near future contribute to a molecular definition of lineage commitment.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Hayday AC,Barber DF,Douglas N,Hoffman ESdoi
10.1006/smim.1999.0180keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
239-49issue
4eissn
1044-5323issn
1096-3618pii
S1044-5323(99)90180-Xjournal_volume
11pub_type
杂志文章,评审abstract::Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is required to allow mouse embryo survival, and the survival of hematopoietic cells during their development and activation. Cla...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2014.03.005
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abstract::Ectodysplasin (Eda) is the most studied tumor necrosis ligand in the field of developmental biology. In all vertebrates studied so far, inactivating germline mutations in Eda lead to the genetic disease called hypohidrotic ectodermal dysplasia (HED). In humans, HED is a life-threatening condition in particular in infa...
journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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abstract::Antibody production is crucial for a successful vaccine response. Beyond the ability of vitamin A (VA) and its active metabolite, all-trans-retinoic acid (RA) to restore growth in VA-deficient animals, supplementation with VA and/or treatment with RA can augment antibody responses in both VA-deficient and VA-adequate ...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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abstract::Signals from the precursor-B cell receptor (pre-BCR) are essential for selection and clonal expansion of pre-B cells that have performed productive immunoglobulin heavy chain V(D)J recombination. In the mouse, the downstream signaling molecules SLP-65 and Btk cooperate to limit proliferation and induce differentiation...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2005.10.002
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abstract::Metazoan parasites typically induce a type 2 immune response, characterized by T helper 2 (Th2) cells that produce the cytokines IL-4, IL-5 and IL-13 among others. The type 2 response is host protective, reducing the number of parasites either through direct killing in the tissues, or expulsion from the intestine. Typ...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1991-11-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.05.001
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journal_title:Seminars in immunology
pub_type: 历史文章,杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2008.03.001
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2011.08.021
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2011.06.007
更新日期:2011-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 社论
doi:10.1016/j.smim.2013.10.001
更新日期:2013-12-15 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2017.09.003
更新日期:2017-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.05.006
更新日期:2009-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1998.0137
更新日期:1998-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1995.0039
更新日期:1995-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2016.10.004
更新日期:2016-10-01 00:00:00
abstract::CR1 (C3b receptor) and CR2 (C3d/EBV receptor) are two C3 receptors expressed on B lymphocytes. CR1 and CR2 have structural similarities and their cross-linking at the B cell surface by antibodies or specific ligands in multimeric forms induce B cell activation. However, activation of human B cells through cell surface...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1990-03-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 评论,杂志文章,评审
doi:10.1006/smim.1999.0192
更新日期:1999-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章
doi:10.1006/smim.1996.0056
更新日期:1997-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2018.08.004
更新日期:2018-08-01 00:00:00
abstract::Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and propagation of autoimmunity. The use of mouse models, which allow eith...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2016.04.001
更新日期:2016-04-01 00:00:00
abstract::Pentraxins are highly conserved components of the humoral arm of innate immunity. They include the short pentraxins C reactive protein (CRP) and serum amyloid P component (SAP), and the long pentraxin PTX3. These are soluble pattern-recognition molecules that are present in the blood and body fluids, and share the abi...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2013.05.002
更新日期:2013-02-01 00:00:00
abstract::It is known that even the adaptive components of the immune system are based on genetic traits common to all individuals, and that diversity is shaped by the lifelong contacts with different non-self antigens, including those found on infectious pathogens. Besides the individual differences, some of these common trait...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2015.03.008
更新日期:2015-03-01 00:00:00