Abstract:
:This review focuses on recessive mutations at three loci whose gene products play critical roles in the development and regulation of the murine immune system. These mutations are: severe combined immunodeficiency (scid), osteopetrosis (op), and motheaten (me). The scid mutation blocks differentiation of functional T and B lymphocytes and interferes with DNA repair processes in multiple cell lineages. The normal gene product at this locus performs a critical function during antigen receptor gene rearrangement as well as during repair of double stranded DNA damage. Homozygosity for op causes impaired development of osteoclasts and other macrophage lineage cells. The op mutation is within the macrophage colony stimulating factor (Csfm) structural gene. Deleterious alleles at the me locus affect lymphoid as well as myeloid cell populations, causing severe immunodeficiency accompanied by systemic autoimmune disease. Determination of the product of the wild type allele at the me locus and the mechanisms by which mutations at this locus disrupt the immune system may reveal important new immunoregulatory processes.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Shultz LDsubject
Has Abstractpub_date
1991-11-01 00:00:00pages
397-408issue
6eissn
1044-5323issn
1096-3618journal_volume
3pub_type
杂志文章,评审abstract::Protein tyrosine phosphatases (PTPs) are a family of enzymes that modulate the cellular level of tyrosine phosphorylation. Based on cellular location, they are classified as receptor like or intracellular PTPs. Structure and function studies have led to the understanding of the enzymatic mechanism of this class of enz...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2000.0209
更新日期:2000-02-01 00:00:00
abstract::Foxp3+CD4+ regulatory T (T(reg)) cells are a key population in controlling the immune response. Recently, their roles have been expanded to broader, non-immune, contexts, in particular the metabolic consequences downstream of obesity-induced inflammation, e.g. type-2 diabetes and cardiovascular disease. This review hi...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2015.07.003
更新日期:2015-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.01.001
更新日期:2009-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2004.09.005
更新日期:2005-02-01 00:00:00
abstract::The MHC class I antigen presentation pathway enables cells infected with intracellular pathogens to signal the presence of the invader to the immune system. Cytotoxic T lymphocytes are able to eliminate the infected cells through recognition of pathogen-derived peptides presented by MHC class I molecules at the cell s...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2015.03.010
更新日期:2015-03-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2018.02.011
更新日期:2018-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1994.1039
更新日期:1994-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2008.04.001
更新日期:2008-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2018.07.002
更新日期:2018-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.11.004
更新日期:2010-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.08.003
更新日期:2009-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2001.0341
更新日期:2002-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2008.03.001
更新日期:2008-06-01 00:00:00
abstract::Bacteria, apoptotic cells and other particulate material are taken up through phagocytosis, a conserved cellular function driven by actin polymerization. As reviewed here, small GTPases of the Rho family, their activators and effectors control the local reorganization of the actin cytoskeleton underneath bound particl...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2001.0331
更新日期:2001-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2016.03.006
更新日期:2016-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1996.0033
更新日期:1996-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2008.07.008
更新日期:2008-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 评论,杂志文章,评审
doi:10.1006/smim.1999.0192
更新日期:1999-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2000.0270
更新日期:2000-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 历史文章,杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2001.0345
更新日期:2002-04-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2011.06.006
更新日期:2011-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1998.0116
更新日期:1998-04-01 00:00:00
abstract::CD4+ regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed t...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2011.11.009
更新日期:2012-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.05.006
更新日期:2009-08-01 00:00:00
abstract::The adaptive immune system, which utilizes RAG-mediated recombination to diversify immune receptors, arose in ancestors of the jawed vertebrates approximately 500 million years ago. Homologs of immunoglobulins (Igs), T cell antigen receptors (TCRs), major histocompatibility complex (MHC) I and II, and the recombinatio...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2004.08.001
更新日期:2004-08-01 00:00:00
abstract::The mechanisms by which alphabeta T-cells are selected in the thymus and then recognize peptide MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with respect to quantification of T-cell sensitivity and the role of self-ligands in T-cell activation has provided some important clues to th...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2007.04.003
更新日期:2007-08-01 00:00:00
abstract::Naturally arising CD4(+) regulatory T cells are critical mediators of peripheral self tolerance and immune homeostasis. Emerging evidence suggests that these cells are a dedicated T cell lineage constitutively acting in a dominant, cell extrinsic manner to regulate immune function. These observations are driving a ree...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2003.12.002
更新日期:2004-04-01 00:00:00
abstract::TCR gamma delta + T cells represent a minority of CD3+ T cells in many species including man. The molecular structure of the TCR gamma and delta loci in man is well understood. The gamma and delta loci contain V, D, J and C gene segments. These segments do not rearrange randomly but in a coordinated, ordered fashion d...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1991-03-01 00:00:00