Abstract:
:The vertebrate innate immune system consists of inflammatory cells and soluble mediators that comprise the first line of defense against microbial infection and, importantly, trigger antigen-specific T and B cell responses that lead to lasting immunity. The molecular mechanisms responsible for microbial non-self recognition by the innate immune system have been elucidated for a large number of pathogens. How the innate immune system recognizes non-microbial non-self, such as organ transplants, is less clear. In this review, we approach this question by describing the principal mechanisms of non-self, or 'damaged' self, recognition by the innate immune system (pattern recognition receptors, the missing self theory, and the danger hypothesis) and discussing whether and how these mechanisms apply to allograft rejection.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Oberbarnscheidt MH,Zecher D,Lakkis FGdoi
10.1016/j.smim.2011.06.006subject
Has Abstractpub_date
2011-08-01 00:00:00pages
264-72issue
4eissn
1044-5323issn
1096-3618pii
S1044-5323(11)00055-8journal_volume
23pub_type
杂志文章,评审abstract::Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory, metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but metabolically active cells that can secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype (...
journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
更新日期:1991-03-01 00:00:00
abstract::In the adult thymus the majority of thymocytes are at a non-proliferating end stage, during which 3% of all CD4+CD8+ cortical thymocytes are selected on the basis of appropriate T-cell antigen-receptor (TcR) specificity to become CD4-CD8+ or CD4+CD8- mature thymocytes. The selected mature cells gradually emigrate to t...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2018.10.009
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2016.03.009
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1998.0146
更新日期:1998-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2008.04.001
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 评论,杂志文章,评审
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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