Abstract：
:In this review we discuss the changes that occur in the B lymphocyte compartment of mice and humans as they progress to old age, focusing on recent advances in this important area of research. Primary areas considered include increased morbidity and mortality in the elderly following infection, and decreased responsiveness to vaccines that evoke primary humoral immune responses, as well as those that evoke responses by memory B cells generated following vaccination and natural infection earlier in life. We then consider some of the mechanisms that may underlie these observed declines in humoral immune function. This includes a discussion of alterations in B cell repertoire and subcompartment distribution, as well as defects in B lymphopoiesis, cell development and homeostasis that may contribute to these alterations, and ultimately to declining protective quality of antibodies produced in the elderly.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Kogut I,Scholz JL,Cancro MP,Cambier JCdoi
10.1016/j.smim.2012.04.004subject
Has Abstractpub_date
2012-10-01 00:00:00pages
342-9issue
5eissn
1044-5323issn
1096-3618pii
S1044-5323(12)00043-7journal_volume
24pub_type
杂志文章,评审abstract：:Since its first description by Wells and Osbourne in 1911, oral tolerance has intrigued researchers due to its potential for therapeutic applications. Oral tolerance can be defined as an inhibition of specific immune responsiveness to subsequent parenteral injections of proteins to which an individual or animal has be...
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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journal_title：Seminars in immunology
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doi：
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journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1992-06-01 00:00:00
