Abstract：
:B cells require signals from multiple sources for their development from precursor cells, and differentiation into effector cells. BAFF has been identified as a critical regulator of B cell development and differentiation. Defects in the production of BAFF and/or expression of its receptors have been associated with a diverse array of human immunopathologies characterised by perturbed B cell function and behaviour, including autoimmunity, malignancy, and immunodeficiency. This review will discuss the role of BAFF in the pathogenesis of these human immune disorders. It will also highlight relevant differences between the function of BAFF in humans and mice and the impact of this on the therapeutic utility of BAFF antagonists in the treatment of different human diseases.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Tangye SG,Bryant VL,Cuss AK,Good KLdoi
10.1016/j.smim.2006.04.004subject
Has Abstractpub_date
2006-10-01 00:00:00pages
305-17issue
5eissn
1044-5323issn
1096-3618pii
S1044-5323(06)00079-0journal_volume
18pub_type
杂志文章,评审abstract：:Follicular dendritic cells (FDCs) were identified decades ago by their ability to retain immune complexes and more recent findings indicate that they are a source of B cell attractants and trophic factors. New imaging studies have shown that B cells closely associate with their dendritic processes during migration. He...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2007.12.001
更新日期：2008-02-01 00:00:00
abstract：:Decades of basic research has established the importance of Ca2+ to various T cell functions, such as cytotoxicity, proliferation, differentiation and cytokine secretion. We now have a good understanding of how proximal TCR signaling initiates Ca2+ influx and how this influx subsequently changes transcriptional activi...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2020.101434
更新日期：2020-06-01 00:00:00
abstract：:Despite the overwhelming success of immunization in reducing, and even eliminating, the global threats posed by a wide spectrum of infectious diseases, attempts to do the same for tuberculosis (TB) have failed to date. While most effective vaccines act by eliciting neutralizing antibodies, T cells are the primary medi...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2014.10.003
更新日期：2014-12-01 00:00:00
abstract：:The frontiers of cancer immunotherapy are extending in terms of both the range of cancer types that can potentially be targeted and the types of therapeutics that are in clinical development. The use of adoptive cellular therapy (ACT) and its derivative, chimeric antigen receptor (CAR) T cells, is currently limited to...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2015.11.003
更新日期：2016-02-01 00:00:00
abstract：:Bacteria, apoptotic cells and other particulate material are taken up through phagocytosis, a conserved cellular function driven by actin polymerization. As reviewed here, small GTPases of the Rho family, their activators and effectors control the local reorganization of the actin cytoskeleton underneath bound particl...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.2001.0331
更新日期：2001-12-01 00:00:00
abstract：:The LTB4 pathway is an attractive target for therapeutic drug development. Two broad classes of drugs have been pursued: antagonists of the primary LTB4 receptors (BLT1 and BLT2) and inhibitors of LTA4 Hydrolase (LTA4H), the rate limiting enzyme in the production of LTB4. An initial wave of effort culminated in the 19...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.08.007
更新日期：2017-10-01 00:00:00
abstract：:As a component of all living cells and microbes, it is not surprising that organisms have evolved mechanisms to detect foreign or aberrant DNA and trigger an innate immune response. TLR9 is an endosomal membrane bound receptor that is widely studied and the best understood DNA sensor. However, the existence of TLR9-in...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2009.05.006
更新日期：2009-08-01 00:00:00
abstract：:T helper 17 (Th17) cells have been reported to be responsible for several chronic inflammatory diseases. However, a peculiar feature of human Th17 cells is that they are very rare in the inflammatory sites in comparison with Th1 cells. The first reason for this rarity is the existence of some self-regulatory mechanism...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2013.10.011
更新日期：2013-11-15 00:00:00
abstract：:Conventional therapies for malignant gliomas (MGs) fail to target tumor cells exclusively, such that their efficacy is ultimately limited by non-specific toxicity. Immunologic targeting of tumor-specific gene mutations, however, may allow more precise eradication of neoplastic cells. The epidermal growth factor recept...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2008.04.001
更新日期：2008-10-01 00:00:00
abstract：:Several mAbs that have been approved for the treatment of cancer make use of complement-dependent cytotoxicity (CDC) to eliminate tumor cells. Comprehensive investigations, based on in vitro studies, mouse models and analyses of patient blood samples after mAb treatment have provided key insights into the details of i...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2016.03.003
更新日期：2016-06-01 00:00:00
abstract：:Vaccinations are powerful tools for combating infections. Because of the age-related impairment in immune functions, the currently available vaccines are protecting only a small proportion of the elderly population. We, here, provide an overview of age-related changes in innate and adaptive immunity with particular em...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2005.05.005
更新日期：2005-10-01 00:00:00
abstract：:Periodontitis is a dysbiotic inflammatory disease leading to the destruction of the tooth-supporting tissues. Current therapies are not always effective and this prevalent oral disease continues to be a significant health and economic burden. Early clinical studies have associated periodontitis with elevated complemen...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2016.03.006
更新日期：2016-06-01 00:00:00
abstract：:Since its first description by Wells and Osbourne in 1911, oral tolerance has intrigued researchers due to its potential for therapeutic applications. Oral tolerance can be defined as an inhibition of specific immune responsiveness to subsequent parenteral injections of proteins to which an individual or animal has be...
journal_title：Seminars in immunology
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.smim.2017.07.004
更新日期：2017-04-01 00:00:00
abstract：:The mammalian alimentary tract harbors hundreds of bacterial species that constitute the indigenous microbial flora. The indigenous microbial flora has long been appreciated for its role in host immune system development. Recent reports suggest that components of the microbial flora differentially affect the proportio...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2011.01.010
更新日期：2011-04-01 00:00:00
abstract：:The discovery of GPI-anchored membrane proteins presented a conundrum for membrane biologists. What could the special purpose be for this type of membrane anchor and why couldn't a transmembrane anchor do the same job? Recent information from several different sources is beginning to provide answers to these questions...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1994.1013
更新日期：1994-04-01 00:00:00
abstract：:The identification of the common lymphoid progenitors in mouse bone marrow allows us to directly assess the regulatory mechanisms of lymphoid lineage commitment. The unexpected finding of a latent myeloid differentiation potential in lymphoid progenitors sheds light on the importance of cytokine receptor expression at...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1044532302000726
更新日期：2002-12-01 00:00:00
abstract：:Increasing interest in the initial steps of hemopoiesis in the embryo is prompted by the lack of information about the primordial origin and the nature of hemopoietic stem cells. It appears critical to understand the emergence, diversification and differentiation potential of hemopoietic cells in the preliver embryo. ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/1044-5323(95)90041-1
更新日期：1995-06-01 00:00:00
abstract：:Heterogeneity in the supramolecular organization of immunological synapses arises from the involvement of different cells, distinct environmental stimuli, and varying levels of protein expression. There may also be heterogeneity in the types and amounts of cell surface proteins and lipids that transfer between lymphoc...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2003.09.005
更新日期：2003-12-01 00:00:00
abstract：:The MHC class I antigen presentation pathway enables cells infected with intracellular pathogens to signal the presence of the invader to the immune system. Cytotoxic T lymphocytes are able to eliminate the infected cells through recognition of pathogen-derived peptides presented by MHC class I molecules at the cell s...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2015.03.010
更新日期：2015-03-01 00:00:00
abstract：:Pentraxins are highly conserved components of the humoral arm of innate immunity. They include the short pentraxins C reactive protein (CRP) and serum amyloid P component (SAP), and the long pentraxin PTX3. These are soluble pattern-recognition molecules that are present in the blood and body fluids, and share the abi...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2013.05.002
更新日期：2013-02-01 00:00:00
abstract：:Mendelian susceptibility to mycobacterial diseases confers predisposition to clinical disease caused by weakly virulent mycobacterial species in otherwise healthy individuals. Since 1996, disease-causing mutations have been found in five autosomal genes (IFNGR1, IFNGR2, STAT1, IL12B, IL12BR1) and one X-linked gene (NE...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2006.07.010
更新日期：2006-12-01 00:00:00
abstract：:TCR gamma delta + T cells represent a minority of CD3+ T cells in many species including man. The molecular structure of the TCR gamma and delta loci in man is well understood. The gamma and delta loci contain V, D, J and C gene segments. These segments do not rearrange randomly but in a coordinated, ordered fashion d...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1991-03-01 00:00:00
abstract：:The signalling mechanisms of the IL-2R remained an enigma until recent years. We now know that IL-2R are coupled to their own unique signalling pathways that complement rather than duplicate TCR signalling. The IL-2R beta- and gamma-chains are essential for signal coupling. Sequence comparisons indicate that portions ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1993.1040
更新日期：1993-10-01 00:00:00
abstract：:Polymorphic MHC is absent from the trophoblast, therefore, it resists NK as well as CTL-mediated lysis in vitro. Activated gamma / delta TCR positive cells are significantly enriched in the decidua as well as in peripheral blood of healthy pregnant women. Human peripheral gamma / delta lymphocytes preferentially expre...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.2000.0318
更新日期：2001-08-01 00:00:00
abstract：:Multiple monoclonal and polyclonal antibody preparations have been shown to neutralize HIV-1 infection in vitro. Upon direct testing in humans, however, many of these have failed to demonstrate clinical efficacy. Hu-PBL-SCID mice offer a model system in which to test the pre-clinical efficacy of antibody preparations....
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1996.0033
更新日期：1996-08-01 00:00:00
abstract：:During lymphocyte development, cell-fate decisions are determined by a myriad of signals produced by the micro- environment of the thymus and the bone marrow. These yet to be fully defined developmental cues regulate stage-specific gene expression, and the extraordinarily well-characterized stages of T and B cell deve...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1998.0153
更新日期：1999-02-01 00:00:00
abstract：:CD4+ helper T cells recognize short peptides stably associated with class II MHC molecules displayed on the surface of antigen presenting cells. Very little is known about the sequence of events that lead to the generation of these peptides from protein antigens. It is likely that native proteins must partially unfold...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1995.0039
更新日期：1995-12-01 00:00:00
abstract：:Mycobacterium tuberculosis remains a major public health burden. It is generally thought that while B cell- and antibody-mediated immunity plays an important role in host defense against extracellular pathogens, the primary control of intracellular microbes derives from cellular immune mechanisms. Studies on the immun...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversit...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2016.03.017
更新日期：2015-12-01 00:00:00
abstract：:This review focuses on recessive mutations at three loci whose gene products play critical roles in the development and regulation of the murine immune system. These mutations are: severe combined immunodeficiency (scid), osteopetrosis (op), and motheaten (me). The scid mutation blocks differentiation of functional T ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1991-11-01 00:00:00
