Abstract：
:The identification of the common lymphoid progenitors in mouse bone marrow allows us to directly assess the regulatory mechanisms of lymphoid lineage commitment. The unexpected finding of a latent myeloid differentiation potential in lymphoid progenitors sheds light on the importance of cytokine receptor expression at this stage. We will discuss the biological nature of common lymphoid progenitors as a model of differentiation from multipotent to lineage committed progenitors. Elucidation of this hidden differentiation potential in progenitors will help further our understanding of the molecular mechanisms that control the cell fate determination of not only common lymphoid progenitors, but also their ancestors, hematopoietic stem cells, and their descendents such as committed T and B cell progenitors.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Prohaska SS,Scherer DC,Weissman IL,Kondo Mdoi
10.1016/s1044532302000726keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
377-84issue
6eissn
1044-5323issn
1096-3618pii
S1044532302000726journal_volume
14pub_type
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