Abstract:
:CD4+ regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Tanoue T,Honda Kdoi
10.1016/j.smim.2011.11.009subject
Has Abstractpub_date
2012-02-01 00:00:00pages
50-7issue
1eissn
1044-5323issn
1096-3618pii
S1044-5323(11)00154-0journal_volume
24pub_type
杂志文章,评审abstract::B cells require signals from multiple sources for their development from precursor cells, and differentiation into effector cells. BAFF has been identified as a critical regulator of B cell development and differentiation. Defects in the production of BAFF and/or expression of its receptors have been associated with a...
journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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abstract::Twenty-five years ago, immunologists and neuroscientists had little science of mutual interest. This is no longer the case. Neuroscientists now know that the first formally defined cytokine, IL-1, activates a discrete population of hypothalamic neurons. This interaction leads to the release of glucocorticoids from the...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:1991-03-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2007.04.003
更新日期:2007-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2001.0310
更新日期:2001-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2004.09.005
更新日期:2005-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2014.06.003
更新日期:2014-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2016.03.003
更新日期:2016-06-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2012.05.005
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1993.1003
更新日期:1993-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:1994-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2016.10.004
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2018.10.009
更新日期:2018-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2018.02.011
更新日期:2018-08-01 00:00:00