Abstract:
:Twenty-five years ago, immunologists and neuroscientists had little science of mutual interest. This is no longer the case. Neuroscientists now know that the first formally defined cytokine, IL-1, activates a discrete population of hypothalamic neurons. This interaction leads to the release of glucocorticoids from the adrenal gland, a hormone that has a long history in immunoregulation. Immunologists have been surprised to learn that lymphoid cells synthesize acetylcholine, the first formally recognized neurotransmitter. This neurotransmitter suppresses the synthesis of TNF. These discoveries blur the distinction of neuroscience and immunology as distinct disciplines. There are now 37 formally recognized cytokines and their receptors, and at least 60 classical neurotransmitters plus over 50 neuroactive peptides. These findings explain why both immunologists and neuroscientists are getting nervous about immunity and highlight a real need to apply integrative physiological approaches in biomedical research.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Kelley KW,McCusker RHdoi
10.1016/j.smim.2014.01.011subject
Has Abstractpub_date
2014-10-01 00:00:00pages
389-93issue
5eissn
1044-5323issn
1096-3618pii
S1044-5323(14)00012-8journal_volume
26pub_type
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.11.004
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abstract::The mechanisms by which alphabeta T-cells are selected in the thymus and then recognize peptide MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with respect to quantification of T-cell sensitivity and the role of self-ligands in T-cell activation has provided some important clues to th...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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abstract::The Ly49 and Nkrp1 loci encode structurally and functionally related cell surface proteins that positively or negatively regulate natural killer (NK) cell-mediated cytotoxicity and cytokine production. Yet despite their clear relatedness and genetic linkage within the NK gene complex (NKC), these two multi-gene famili...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2008.05.004
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2017.08.007
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journal_title:Seminars in immunology
pub_type: 杂志文章
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2013.10.011
更新日期:2013-11-15 00:00:00
abstract::Polymorphic MHC is absent from the trophoblast, therefore, it resists NK as well as CTL-mediated lysis in vitro. Activated gamma / delta TCR positive cells are significantly enriched in the decidua as well as in peripheral blood of healthy pregnant women. Human peripheral gamma / delta lymphocytes preferentially expre...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.2000.0318
更新日期:2001-08-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2012.04.007
更新日期:2012-10-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2005.10.002
更新日期:2006-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2004.09.005
更新日期:2005-02-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章
doi:10.1016/j.smim.2011.04.002
更新日期:2011-08-01 00:00:00
abstract::The tyrosine activating motif (TAM) is a conserved signaling motif present in many hematopoietic receptors. Although the exact definition and the function of these motifs is not known, it is likely that these motifs bind and activate protein tyrosine kinases. Here we summarize the data regarding tyrosine kinase intera...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/1044-5323(95)90003-9
更新日期:1995-02-01 00:00:00
abstract::The Fas system ensures, within the immune system, one of the two main pathways of T-cell mediated cytotoxicity, and, importantly, at least part of the downregulation of immune responses. Recently, Fas has been increasingly implicated in other functions, such as protection of immune privileged tissues and disposal of c...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1997.0062
更新日期:1997-04-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2015.03.008
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1999.0169
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1994.1039
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1006/smim.1994.1013
更新日期:1994-04-01 00:00:00
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journal_title:Seminars in immunology
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abstract::Despite the overwhelming success of immunization in reducing, and even eliminating, the global threats posed by a wide spectrum of infectious diseases, attempts to do the same for tuberculosis (TB) have failed to date. While most effective vaccines act by eliciting neutralizing antibodies, T cells are the primary medi...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2009.05.006
更新日期:2009-08-01 00:00:00
abstract::CD4+ regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed t...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.smim.2011.11.009
更新日期:2012-02-01 00:00:00
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journal_title:Seminars in immunology
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doi:10.1016/j.smim.2009.10.001
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journal_title:Seminars in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1044-5323(02)00127-6
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abstract::The signalling mechanisms of the IL-2R remained an enigma until recent years. We now know that IL-2R are coupled to their own unique signalling pathways that complement rather than duplicate TCR signalling. The IL-2R beta- and gamma-chains are essential for signal coupling. Sequence comparisons indicate that portions ...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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更新日期:1993-10-01 00:00:00
abstract::Interferon epsilon (IFNε) is a type I IFN with unusual patterns of expression and therefore, function. It is constitutively expressed by reproductive tract epithelium and regulated by hormones during estrus cycle, reproduction, and menopause and by exogenous hormones. The IFNe protein is encoded by a gene in the type ...
journal_title:Seminars in immunology
pub_type: 杂志文章,评审
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