Abstract：
:Polymorphic MHC is absent from the trophoblast, therefore, it resists NK as well as CTL-mediated lysis in vitro. Activated gamma / delta TCR positive cells are significantly enriched in the decidua as well as in peripheral blood of healthy pregnant women. Human peripheral gamma / delta lymphocytes preferentially express the V gamma 9/V delta 2 TCR, whereas those of the decidua use the V delta 1 chain. These subpopulations are functionally polarized, the former being Th1, the latter Th2. Potentially cytotoxic V delta 2+ lymphocytes recognize HLA-E on the trophoblast via the CD94/NKG2A receptor, which induces an inhibitory signal, thus potentially inhibiting Th1 type cytokine production.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Szekeres-Bartho J,Barakonyi A,Miko E,Polgar B,Palkovics Tdoi
10.1006/smim.2000.0318keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
229-33issue
4eissn
1044-5323issn
1096-3618pii
S1044-5323(00)90318-Xjournal_volume
13pub_type
杂志文章,评审abstract：:B cell tolerance is described as the absence of a measurable antibody forming response to an antigenic challenge. The establishment of antigen-specific tolerance requires, by definition, engagement of the B cell antigen-specific receptor. However, only in some circumstances does this engagement lead to tolerance, whil...
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