Abstract:
:In a panel of wild mice trapped in different geographical regions, the concomitant expression of V beta 17 T cell receptors and I-E histocompatibility molecules is frequent. By Southern blot analysis, eight forms of V beta 17 genes have been distinguished that encode five kinds of V beta 17 domains. Populations of Asia display the highest level of polymorphism and include all the V beta 17 forms and domains. The V beta 17 T cells of wild origin are deleted in mice expressing Mls-3 and related superantigens. Wild mice use V beta 17 domains different than the one of laboratory strains. Together with endogenous superantigens polymorphism, this accounts for the observed low frequency of clonal deletion cases in natural populations.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Jouvin-Marche E,Marche PN,Cazenave PAkeywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
305-12issue
5eissn
1044-5323issn
1096-3618journal_volume
4pub_type
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