Prevention of B cell clonal deletion and anergy by activated T cells and their lymphokines.

Abstract:

:B cell tolerance is described as the absence of a measurable antibody forming response to an antigenic challenge. The establishment of antigen-specific tolerance requires, by definition, engagement of the B cell antigen-specific receptor. However, only in some circumstances does this engagement lead to tolerance, while in others it produces B cell activation and secretion of immunoglobulins. Several mechanisms occur naturally in vivo abrogating the expression of deleterious autoantibodies and contributing to the state of self-tolerance. In this review, we will examine different ways in which B cell tolerance can be broken, focusing on evidence showing that activated-T cells and/or their lymphokines can prevent B cell clonal deletion and thus have a potential role in the pathogenesis of autoimmune diseases. This approach is based on the well-known association of several lymphokines, such as IL-1, IL-2, IL-4, IL-5, and type I interferons, with autoimmune phenomena in vivo.

journal_name

Semin Immunol

journal_title

Seminars in immunology

authors

Alés-Martínez JE,Cuende E,Gaur A,Scott DW

keywords:

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

195-202

issue

3

eissn

1044-5323

issn

1096-3618

journal_volume

4

pub_type

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