The protean immune cell synapse: a supramolecular structure with many functions.

Abstract:

:Heterogeneity in the supramolecular organization of immunological synapses arises from the involvement of different cells, distinct environmental stimuli, and varying levels of protein expression. There may also be heterogeneity in the types and amounts of cell surface proteins and lipids that transfer between lymphocytes during immune surveillance. In addition, immune cells can be involved in the assembly of a 'viral synapse', such that micrometer-scale organization of proteins at intercellular contacts occurs during transmission of a virus between T cells. Thus, while there may be unity in molecular mechanisms underlying the organization of cell surface receptors at immune cell synapses, there is diversity in their function.

journal_name

Semin Immunol

journal_title

Seminars in immunology

authors

Davis DM,Igakura T,McCann FE,Carlin LM,Andersson K,Vanherberghen B,Sjöström A,Bangham CR,Höglund P

doi

10.1016/j.smim.2003.09.005

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

317-24

issue

6

eissn

1044-5323

issn

1096-3618

pii

S104453230300071X

journal_volume

15

pub_type

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