Abstract：
:Periodontitis is a dysbiotic inflammatory disease leading to the destruction of the tooth-supporting tissues. Current therapies are not always effective and this prevalent oral disease continues to be a significant health and economic burden. Early clinical studies have associated periodontitis with elevated complement activity. Consistently, subsequent genetic and pharmacological studies in rodents have implicated the central complement component C3 and downstream signaling pathways in periodontal host-microbe interactions that promote dysbiosis and inflammatory bone loss. This review discusses these mechanistic advances and moreover focuses on the compstatin family of C3 inhibitors as a novel approach to treat periodontitis. In this regard, local application of the current lead analog Cp40 was recently shown to block both inducible and naturally occurring periodontitis in non-human primates. These promising results from non-human primate studies and the parallel development of Cp40 for clinical use highlight the feasibility for developing an adjunctive, C3-targeted therapy for human periodontitis.
journal_name
Semin Immunoljournal_title
Seminars in immunologyauthors
Hajishengallis G,Hajishengallis E,Kajikawa T,Wang B,Yancopoulou D,Ricklin D,Lambris JDdoi
10.1016/j.smim.2016.03.006subject
Has Abstractpub_date
2016-06-01 00:00:00pages
285-91issue
3eissn
1044-5323issn
1096-3618pii
S1044-5323(16)00013-0journal_volume
28pub_type
杂志文章,评审abstract：:The molecular and cellular mechanisms of allergen tolerance in humans have been intensively studied in the past few decades. The demonstration of epitope-specific T cell tolerance, particularly mediated by the immune suppressor functions of IL-10 led to a major conceptual change in this area more than 20 years ago. Cu...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2019.101326
更新日期：2019-08-01 00:00:00
abstract：:Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential b...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2015.11.002
更新日期：2016-02-01 00:00:00
abstract：:Many human cancers possess a complex chemokine network that may influence the extent and phenotype of the leukocyte infiltrate, angiogenesis, tumor cell growth, survival and migration. Restricted expression of chemokine receptors on leukocytes may allow concise control of cell movement and retention at the tumor site....
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1044-5323(02)00127-6
更新日期：2003-02-01 00:00:00
abstract：:Viral infections often result in long-term immunological memory. This article reviews the phenotypic changes seen in memory T cells and suggests a re-evaluation of the current dogma that T cell memory is maintained by persistence of antigen. ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：:Several studies have demonstrated how different cell types of mesenchymal and myeloid origin can independently exhibit immunoregulatory activities. In response to inflammatory cues, they transcribe a molecular repertoire that restores the tissue microenvironment to what it was before the injury. There is accumulating ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2018.01.002
更新日期：2018-02-01 00:00:00
abstract：:Antibody production is crucial for a successful vaccine response. Beyond the ability of vitamin A (VA) and its active metabolite, all-trans-retinoic acid (RA) to restore growth in VA-deficient animals, supplementation with VA and/or treatment with RA can augment antibody responses in both VA-deficient and VA-adequate ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2008.08.004
更新日期：2009-02-01 00:00:00
abstract：:The adaptive immune system, which utilizes RAG-mediated recombination to diversify immune receptors, arose in ancestors of the jawed vertebrates approximately 500 million years ago. Homologs of immunoglobulins (Igs), T cell antigen receptors (TCRs), major histocompatibility complex (MHC) I and II, and the recombinatio...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2004.08.001
更新日期：2004-08-01 00:00:00
abstract：:The ability of the mucosal immune system to distinguish between harmful and harmless antigens is essential for mounting protective immune responses and preventing the induction of mucosal pathology yet the basis for this remains unclear. As fed antigen can also exert systemic effects understanding oral tolerance and p...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.2001.0310
更新日期：2001-06-01 00:00:00
abstract：:The signalling mechanisms of the IL-2R remained an enigma until recent years. We now know that IL-2R are coupled to their own unique signalling pathways that complement rather than duplicate TCR signalling. The IL-2R beta- and gamma-chains are essential for signal coupling. Sequence comparisons indicate that portions ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1993.1040
更新日期：1993-10-01 00:00:00
abstract：:The Fas system ensures, within the immune system, one of the two main pathways of T-cell mediated cytotoxicity, and, importantly, at least part of the downregulation of immune responses. Recently, Fas has been increasingly implicated in other functions, such as protection of immune privileged tissues and disposal of c...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1997.0062
更新日期：1997-04-01 00:00:00
abstract：:Multiple sclerosis (MS) is an idiopathic autoimmune neurodegenerative disease. Like many common diseases, MS has a genetic component; however, as with most complex diseases, the genetic architecture may be influenced by heterogeneity, incomplete penetrance, polygenic inheritance, and environmental factors. This clinic...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2009.08.003
更新日期：2009-12-01 00:00:00
abstract：:In the past decade accumulating evidence supported the view that the immune system should be regarded as trust consisting of several branches. In this review, we will first introduce the architectural features comprising the intestinal immune system emphasising its plasticity and subsequently discuss the concepts desc...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2008.03.001
更新日期：2008-06-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co-opt MSCs and re-program their functional profile from normally trophic to pro-tumorigenic. These tumor-derived small vesicles called "TEX" carry and ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.12.003
更新日期：2018-02-01 00:00:00
abstract：:A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available f...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2020.101388
更新日期：2020-02-01 00:00:00
abstract：:Autoantigens that contain DNA, RNA, or self-IgG are preferred targets for autoantibodies in systemic lupus erythematosus (SLE). B cells promote SLE pathogenesis by producing autoantibodies, activating autoreactive T cells, and secreting cytokines. We discuss how certain autoreactive B cells are selectively activated, ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2006.12.005
更新日期：2007-02-01 00:00:00
abstract：:Autoimmune diseases have been studied from the perspective of an abnormal immune response in genetically vulnerable hosts. Although the immune response is responsible for the initiation of autoimmune diseases, the effectors of the disease process likely involves cytokines such as interleukin-1 (IL-1) and tumor necrosi...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：
更新日期：1992-06-01 00:00:00
abstract：:Many immune cells can detect the direction and intensity of an extracellular chemical gradient, and migrate toward the source of stimulus. This process, called chemotaxis, is essential for immune system function and homeostasis, and its deregulation is associated with serious diseases. Chemotaxis is initiated by chemo...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2004.09.005
更新日期：2005-02-01 00:00:00
abstract：:Viral and microbial pathogens contain specific motifs or pathogen-associated molecular patterns (PAMPs) that are recognized by cell surface- and endosome-associated Toll-like receptors (TLRs). RNA virus infection is also detected through TLR-independent mechanisms. Early viral replicative intermediates are detected by...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2009.05.001
更新日期：2009-08-01 00:00:00
abstract：:Conventional therapies for malignant gliomas (MGs) fail to target tumor cells exclusively, such that their efficacy is ultimately limited by non-specific toxicity. Immunologic targeting of tumor-specific gene mutations, however, may allow more precise eradication of neoplastic cells. The epidermal growth factor recept...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2008.04.001
更新日期：2008-10-01 00:00:00
abstract：:The LTB4 pathway is an attractive target for therapeutic drug development. Two broad classes of drugs have been pursued: antagonists of the primary LTB4 receptors (BLT1 and BLT2) and inhibitors of LTA4 Hydrolase (LTA4H), the rate limiting enzyme in the production of LTB4. An initial wave of effort culminated in the 19...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2017.08.007
更新日期：2017-10-01 00:00:00
abstract：:A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its pro...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2018.10.009
更新日期：2018-12-01 00:00:00
abstract：:Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory, metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but metabolically active cells that can secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype (...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2019.04.003
更新日期：2018-12-01 00:00:00
abstract：:Secondary, so-called costimulatory, signals are critically required for the process of T cell activation. Since landmark studies defined that T cells receiving a T cell receptor signal without a costimulatory signal, are tolerized in vitro, the investigation of T cell costimulation has attracted intense interest. Earl...
journal_title：Seminars in immunology
pub_type： 杂志文章
doi：10.1016/j.smim.2011.04.002
更新日期：2011-08-01 00:00:00
abstract：:The discovery of GPI-anchored membrane proteins presented a conundrum for membrane biologists. What could the special purpose be for this type of membrane anchor and why couldn't a transmembrane anchor do the same job? Recent information from several different sources is beginning to provide answers to these questions...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1994.1013
更新日期：1994-04-01 00:00:00
abstract：:Naturally arising CD4(+) regulatory T cells are critical mediators of peripheral self tolerance and immune homeostasis. Emerging evidence suggests that these cells are a dedicated T cell lineage constitutively acting in a dominant, cell extrinsic manner to regulate immune function. These observations are driving a ree...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2003.12.002
更新日期：2004-04-01 00:00:00
abstract：:The ability of the immune system to discriminate between healthy-self, abnormal-self, and non-self has been attributed mainly to alarmins signaling as "danger signals". It is now evident, however, that alarmins are much more complex and can perform specialized functions that can regulate a wide spectrum of processes r...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2018.08.004
更新日期：2018-08-01 00:00:00
abstract：:The complement system covalently attaches C3d to microbial antigens which binds to CR2 on B lymphocytes, leading to a markedly enhanced adaptive immune response to that antigen. The enhancement is mediated by the cross-linking of the CR2-CD19 complex to mIg which augments the activation of several intracellular signal...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1998.0137
更新日期：1998-10-01 00:00:00
abstract：:The tyrosine activating motif (TAM) is a conserved signaling motif present in many hematopoietic receptors. Although the exact definition and the function of these motifs is not known, it is likely that these motifs bind and activate protein tyrosine kinases. Here we summarize the data regarding tyrosine kinase intera...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/1044-5323(95)90003-9
更新日期：1995-02-01 00:00:00
abstract：:The OX-40 receptor (OX-40R) is a transmembrane protein found on the surface of activated CD4(+) T cells. When engaged by an agonist such as anti-OX-40 antibody or the OX-40 ligand (OX-40L) during antigen presentation to T cell lines, the OX-40R generates a costimulatory signal that is as potent as CD28 costimulation. ...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1006/smim.1998.0146
更新日期：1998-12-01 00:00:00
abstract：:The vertebrate innate immune system consists of inflammatory cells and soluble mediators that comprise the first line of defense against microbial infection and, importantly, trigger antigen-specific T and B cell responses that lead to lasting immunity. The molecular mechanisms responsible for microbial non-self recog...
journal_title：Seminars in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.smim.2011.06.006
更新日期：2011-08-01 00:00:00
