abstract：:Circular RNAs (circRNAs) are covalently circularized RNA moieties that despite being relatively abundant were only recently identified and have only begun to be investigated within the last couple of years. Even though there are many thousands of genes that appear capable of producing circRNAs, and the fact that many ...

journal_title：Advances in clinical chemistry

authors： Solé C,Lawrie CH

更新日期：2020-01-01 00:00:00

abstract：:Metaproteomics, as a subfield of proteomics, has quickly emerged as a pivotal tool for global characterization of a microbiome system at a functional level. It has been increasingly applied in studying human digestive and metabolic diseases, and provides information-rich data to identify the dysbiosis of human gut mic...

journal_title：Advances in clinical chemistry

authors： Pan S,Chen R

更新日期：2020-01-01 00:00:00

abstract：:Exercise is a well-known non-pharmacologic agent used to prevent and treat a wide range of pathologic conditions such as metabolic and cardiovascular disease. In this sense, the classic field of exercise physiology has determined the main theoretical and practical bases of physiologic adaptations in response to exerci...

journal_title：Advances in clinical chemistry

authors： Gomes C,Almeida JA,Franco OL,Petriz B

更新日期：2020-01-01 00:00:00

abstract：:Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control and manipulation, enabling rapid and high-throughput sample processing in integrated micro-scale medical systems. These platforms are well-suited for both standard clinical settings and point-of-care applications. The uni...

journal_title：Advances in clinical chemistry

authors： Burklund A,Tadimety A,Nie Y,Hao N,Zhang JXJ

更新日期：2020-01-01 00:00:00

abstract：:Hypertensive disorders of pregnancy (HDP) is the most common and widely known as serious complication of pregnancy. As this syndrome is a major leading cause of maternal, fetal, and neonatal morbidity/mortality worldwide, many studies have sought to identify candidate molecules as potential disease biomarkers (DBMs) f...

journal_title：Advances in clinical chemistry

authors： Araki Y,Yanagida M

更新日期：2020-01-01 00:00:00

abstract：:Aggressive behavior exerts an enormous impact on society remaining among the main causes of worldwide premature death. Effective primary interventions, relying on predictive models of aggression that show adequate sensitivity and specificity are currently lacking. One strategy to increase the accuracy and precision of...

journal_title：Advances in clinical chemistry

authors： Manchia M,Comai S,Pinna M,Pinna F,Fanos V,Denovan-Wright E,Carpiniello B

更新日期：2019-01-01 00:00:00

abstract：:Specific nucleic acid detection in vitro or in vivo has become increasingly important in the discovery of genetic diseases, diagnosing pathogen infection and monitoring disease treatment. One challenge, however, is that the amount of target nucleic acid in specimens is limited. Furthermore, direct sensing methods are ...

journal_title：Advances in clinical chemistry

authors： Zhou H,Liu J,Xu JJ,Zhang S,Chen HY

更新日期：2019-01-01 00:00:00

abstract：:Although the measures to improve quality in the clinical laboratory have been enormous in the past years, not least of all due to the introduction of the ISO standards 15189 and 17025, the handling of validation and verification of method performance often still differs widely from laboratory to laboratory. Much of wh...

journal_title：Advances in clinical chemistry

authors： Pum J

更新日期：2019-01-01 00:00:00

abstract：:The abnormal breakdown of circulating red blood cells (RBCs), also known as hemolysis, is a significant clinical issue that can present as a primary disorder or arise secondary to another disease process. The evaluation for pathologic hemolysis (and the establishment of a hemolytic disorder) is heavily dependent on as...

journal_title：Advances in clinical chemistry

authors： Siddon AJ,Tormey CA

更新日期：2019-01-01 00:00:00

abstract：:Glutathione (GSH), often referred to as "the master antioxidant," participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damage and thus as expected, GSH imbalance is observed in a wide range of ...

journal_title：Advances in clinical chemistry

authors： Teskey G,Abrahem R,Cao R,Gyurjian K,Islamoglu H,Lucero M,Martinez A,Paredes E,Salaiz O,Robinson B,Venketaraman V

更新日期：2018-01-01 00:00:00

abstract：:Cataract is a major cause of blindness worldwide. It is characterized by lens opacification and is accompanied by extensive posttranslational modifications (PTMs) in various proteins. PTMs play an essential role in lens opacification. Several PTMs have been described in proteins isolated from relatively old human lens...

journal_title：Advances in clinical chemistry

authors： Zhang K,Zhu X,Lu Y

更新日期：2018-01-01 00:00:00

abstract：:In Part II of this review we consider the very common case of multiple inputs to a measurement process. We derive, using only elementary steps and the basic mathematics covered in Part I, the formula for the propagation of uncertainties from the inputs to the output. The Gaussian density distribution is briefly explai...

journal_title：Advances in clinical chemistry

authors： Frenkel RB,Farrance I

更新日期：2018-01-01 00:00:00

abstract：:The majority of cancer-related deaths result from metastasis, the process by which cancer cells escape the primary tumor site and enter into the blood circulation in order to disseminate to secondary locations throughout the body. Tumor cells found within the circulation are referred to as circulating tumor cells (CTC...

journal_title：Advances in clinical chemistry

authors： Lowes LE,Allan AL

更新日期：2018-01-01 00:00:00

abstract：:Hypoxemia (systemic oxygen desaturation) marks the presence, risk, and progression of many diseases. Episodic or nocturnal hypoxemia can be challenging to detect and quantify. A sensitive, specific, and convenient marker of recent oxygen desaturation represents an unmet medical need. Observations of acclimatization to...

journal_title：Advances in clinical chemistry

authors： Yčas JW

更新日期：2017-01-01 00:00:00

abstract：:The generation of bulky DNA adducts consists of conjugates formed between large reactive electrophiles and DNA-binding sites. The term "bulky DNA adducts" comes from early experiments that employed a 32P-DNA postlabeling approach. This technique has long been used to elucidate the association between adducts and carci...

journal_title：Advances in clinical chemistry

authors： Munnia A,Giese RW,Polvani S,Galli A,Cellai F,Peluso MEM

更新日期：2017-01-01 00:00:00

abstract：:Laboratory testing for drugs of abuse has become standard practice in many settings both forensic and clinical. Urine is the predominant specimen, but other specimens are possible including hair, nails, sweat, and oral fluid. Point-of-care test kits provide for rapid analysis at the site where specimens are collected ...

journal_title：Advances in clinical chemistry

authors： Wiencek JR,Colby JM,Nichols JH

更新日期：2017-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease occurs in significant percentage of general population. NAFLD is closely associated with entire spectrum of metabolic-related disorders including diabetes, obesity, and cardiovascular diseases. Considering several similar pathways underpinning metabol...

journal_title：Advances in clinical chemistry

authors： Shabani P,Emamgholipour S,Doosti M

更新日期：2017-01-01 00:00:00

abstract：:Metabolomics is the quantitative analysis of a large number of low molecular weight metabolites that are intermediate or final products of all the metabolic pathways in a living organism. Any metabolic profiles detectable in a human biological fluid are caused by the interaction between gene expression and the environ...

journal_title：Advances in clinical chemistry

authors： Noto A,Fanos V,Dessì A

更新日期：2016-01-01 00:00:00

abstract：:The application of simple, cost-effective, rapid, and accurate diagnostic technologies for detection and identification of cardiac and cancer biomarkers has been a central point in the clinical area. Biosensors have been recognized as efficient alternatives for the diagnostics of various diseases due to their specific...

journal_title：Advances in clinical chemistry

authors： Justino CI,Duarte AC,Rocha-Santos TA

更新日期：2016-01-01 00:00:00

abstract：:Menopause is a risk factor for cardiometabolic diseases, including metabolic syndrome (MetS), type 2 diabetes, and cardiovascular diseases. MetS is a constellation of interdependent factors such as insulin resistance, abdominal obesity, dyslipidemia, and hypertension. The prevalence of MetS in postmenopause is due to ...

journal_title：Advances in clinical chemistry

authors： Stefanska A,Bergmann K,Sypniewska G

更新日期：2015-01-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age affecting various functions including reproduction and metabolism. This syndrome is associated with increased prevalence of subclinical cardiovascular disease as well as endometrial and ovarian cancer. This syndrome is high...

journal_title：Advances in clinical chemistry

authors： Ilie IR,Georgescu CE

更新日期：2015-01-01 00:00:00

abstract：:Deregulated DNA replication occurs in cancer where it contributes to genomic instability. This process is a target of cytotoxic therapies. Chemotherapies exploit high DNA replication in cancer cells by modifying the DNA template or by inhibiting vital enzymatic activities that lead to slowing or stalling replication f...

journal_title：Advances in clinical chemistry

authors： Kotsantis P,Jones RM,Higgs MR,Petermann E

更新日期：2015-01-01 00:00:00

abstract：:Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system relies on molecules to directly quench ROS and the enzymatic system is composed of specific enzymes that detoxify ROS. Among the latter, the sup...

journal_title：Advances in clinical chemistry

authors： Bresciani G,da Cruz IB,González-Gallego J

更新日期：2015-01-01 00:00:00

abstract：:Human adults produce around 1000 mmol of ammonia daily. Some is reutilized in biosynthesis. The remainder is waste and neurotoxic. Eventually most is excreted in urine as urea, together with ammonia used as a buffer. In extrahepatic tissues, ammonia is incorporated into nontoxic glutamine and released into blood. Larg...

journal_title：Advances in clinical chemistry

authors： Walker V

更新日期：2014-01-01 00:00:00

abstract：:The primary role of the clinical laboratory is to report accurate results for diagnosis of disease and management of illnesses. This goal has, to a large extent been achieved for routine biochemical tests, but not for immunoassays which remained susceptible to interference from endogenous immunoglobulin antibodies, ca...

journal_title：Advances in clinical chemistry

authors： Ismail AA

更新日期：2014-01-01 00:00:00

abstract：:Sepsis is the primary cause of death in the intensive care unit. The prevention of sepsis complications requires an early and accurate diagnosis as well as the appropriate mon itoring. A deep knowledge of the immunologic basis of sepsis is essential to better understand the scope of incorporating a new marker into cli...

journal_title：Advances in clinical chemistry

authors： Prieto B,Alvarez Menéndez FV

更新日期：2014-01-01 00:00:00

abstract：:In addition to their historical role, autoantibodies appear promising as biomarkers to facilitate diagnosis, improve patient outcome and decrease mortality in cancer. Autoantibodies may also be useful in the identification of subjects at risk for cancer, that is, those bearing premalignant changes. Numerous studies ha...

journal_title：Advances in clinical chemistry

authors： Fernández-Madrid F,Maroun MC

更新日期：2014-01-01 00:00:00

abstract：:Since the discovery of group-specific component and its polymorphism by Hirschfeld in 1959, research has put spotlight on this multifunctional transport protein (vitamin D binding protein, DBP). Besides the transport of vitamin D metabolites, DBP is a plasma glycoprotein with many important functions, including seques...

journal_title：Advances in clinical chemistry

authors： Speeckaert MM,Speeckaert R,van Geel N,Delanghe JR

更新日期：2014-01-01 00:00:00

abstract：:Marine organisms are a rich source of sulfated polysaccharides with unique structures. Fucosylated chondroitin sulfate (FucCS) from the sea cucumber Ludwigothurea grisea and sulfated galactan from the red alga Botryocladia occidentalis are one of these unusual molecules. Besides their uncommon structures, they also ex...

journal_title：Advances in clinical chemistry

authors： Glauser BF,Mourão PA,Pomin VH

更新日期：2013-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD), the most common liver disorder worldwide, encompasses a spectrum of abnormal liver histology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Population studies show that NAFLD is strongly associated with insulin resistance, obesity, type 2 d...

journal_title：Advances in clinical chemistry

authors： Armutcu F,Akyol S,Ucar F,Erdogan S,Akyol O

更新日期：2013-01-01 00:00:00

abstract：:Mechanisms postulated to link folate and B12 metabolism with cancer, including genome-wide hypomethylation, gene-specific promoter hypermethylation, and DNA uracil misincorporation, have been observed in prostate tumor cells. However, epidemiological studies of prostate cancer risk, based on dietary intakes and blood ...

journal_title：Advances in clinical chemistry

authors： Collin SM

更新日期：2013-01-01 00:00:00

abstract：:The recent development and introduction into clinical and laboratory practice of the novel highly sensitive cardiac troponin assays has contributed to improve the diagnosis and risk stratification of patients presenting with suspected myocardial injury and acute coronary syndrome at the emergency department (ED). The ...

journal_title：Advances in clinical chemistry

authors： Lippi G,Montagnana M,Aloe R,Cervellin G

更新日期：2012-01-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of other types of cancer, patients with mesothelioma currently face ...

journal_title：Advances in clinical chemistry

authors： Rodríguez Portal JA

更新日期：2012-01-01 00:00:00

abstract：:Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity o...

journal_title：Advances in clinical chemistry

authors： Boldt AB,Goeldner I,de Messias-Reason IJ

更新日期：2012-01-01 00:00:00

abstract：:Aromatase is a specific component of the cytochrome P450 enzyme system that is responsible for the transformation of C19 androgen precursors into C18 estrogenic compounds. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is expressed in ovary and testis not only but also in many extraglan...

journal_title：Advances in clinical chemistry

authors： Gennari L,Merlotti D,Nuti R

更新日期：2011-01-01 00:00:00

abstract：:During winter hibernation, small mammals fall into long periods of deep cold torpor where metabolic rate is suppressed by > 90% and core body temperature can fall to near 0 degrees C. Studies with hibernators illustrate the molecular regulatory mechanisms that coordinate the suppression of metabolic functions during t...

journal_title：Advances in clinical chemistry

authors： Storey KB,Storey JM

更新日期：2010-01-01 00:00:00

abstract：:Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the alimentary tract, and E type PGs are most effective in these actions. PGE2 protects against acid reflux esophagitis and affords gastric cytoprotection against ethanol and indomethacin. These effects ...

journal_title：Advances in clinical chemistry

authors： Takeuchi K

更新日期：2010-01-01 00:00:00

abstract：:This review examines in vitro and in vivo studies, indicating that bilirubin inhibits lipid oxidation and oxygen radical formation. Experimental and epidemiological evidence is presented that suggests that bilirubin may serve as a physiological antioxidant providing protection against cardiovascular disease. Special a...

journal_title：Advances in clinical chemistry

authors： Franchini M,Targher G,Lippi G

更新日期：2010-01-01 00:00:00

abstract：:Publication of the human proteome has prompted efforts to develop high-throughput techniques that can catalogue and quantify proteins and peptides present in different tissue types. The field of proteomics aims to identify, quantify, analyze, and functionally define a large number of proteins in cellular processes in ...

journal_title：Advances in clinical chemistry

authors： Sigdel TK,Klassen RB,Sarwal MM

更新日期：2009-01-01 00:00:00

abstract：:Biomarkers are increasingly employed in empirical studies of human populations to understand physiological processes that change with age, diseases whose onset appears linked to age, and the aging process itself. In this chapter, we describe some of the most commonly used biomarkers in population aging research, inclu...

journal_title：Advances in clinical chemistry

authors： Crimmins E,Vasunilashorn S,Kim JK,Alley D

更新日期：2008-01-01 00:00:00