Glutathione as a Marker for Human Disease.

Abstract:

:Glutathione (GSH), often referred to as "the master antioxidant," participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damage and thus as expected, GSH imbalance is observed in a wide range of pathological conditions including tuberculosis (TB), HIV, diabetes, cancer, and aging. Consequently, it is not surprising that GSH has attracted the attention of biological researchers and pharmacologists alike as a possible target for medical intervention. Here, we discuss the role GSH plays amongst these pathological conditions to illuminate how it can be used as a marker for human disease.

journal_name

Adv Clin Chem

authors

Teskey G,Abrahem R,Cao R,Gyurjian K,Islamoglu H,Lucero M,Martinez A,Paredes E,Salaiz O,Robinson B,Venketaraman V

doi

10.1016/bs.acc.2018.07.004

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

141-159

eissn

0065-2423

issn

2162-9471

pii

S0065-2423(18)30039-8

journal_volume

87

pub_type

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