Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome.

abstract：:Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system relies on molecules to directly quench ROS and the enzymatic system is composed of specific enzymes that detoxify ROS. Among the latter, the sup...

journal_title：Advances in clinical chemistry

authors： Bresciani G,da Cruz IB,González-Gallego J

更新日期：2015-01-01 00:00:00

abstract：:Hypoxemia (systemic oxygen desaturation) marks the presence, risk, and progression of many diseases. Episodic or nocturnal hypoxemia can be challenging to detect and quantify. A sensitive, specific, and convenient marker of recent oxygen desaturation represents an unmet medical need. Observations of acclimatization to...

journal_title：Advances in clinical chemistry

authors： Yčas JW

更新日期：2017-01-01 00:00:00

abstract：:The generation of bulky DNA adducts consists of conjugates formed between large reactive electrophiles and DNA-binding sites. The term "bulky DNA adducts" comes from early experiments that employed a 32P-DNA postlabeling approach. This technique has long been used to elucidate the association between adducts and carci...

journal_title：Advances in clinical chemistry

authors： Munnia A,Giese RW,Polvani S,Galli A,Cellai F,Peluso MEM

更新日期：2017-01-01 00:00:00

abstract：:Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the alimentary tract, and E type PGs are most effective in these actions. PGE2 protects against acid reflux esophagitis and affords gastric cytoprotection against ethanol and indomethacin. These effects ...

journal_title：Advances in clinical chemistry

authors： Takeuchi K

更新日期：2010-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) are covalently circularized RNA moieties that despite being relatively abundant were only recently identified and have only begun to be investigated within the last couple of years. Even though there are many thousands of genes that appear capable of producing circRNAs, and the fact that many ...

journal_title：Advances in clinical chemistry

authors： Solé C,Lawrie CH

更新日期：2020-01-01 00:00:00

abstract：:Exercise is a well-known non-pharmacologic agent used to prevent and treat a wide range of pathologic conditions such as metabolic and cardiovascular disease. In this sense, the classic field of exercise physiology has determined the main theoretical and practical bases of physiologic adaptations in response to exerci...

journal_title：Advances in clinical chemistry

authors： Gomes C,Almeida JA,Franco OL,Petriz B

更新日期：2020-01-01 00:00:00

abstract：:Anti-endothelial cell antibodies (AECA) represent a heterogeneous family of autoantibodies directed against structural endothelial proteins, as well as antigens adhering to endothelial cells. Although AECA immunoassays still show a high-interlaboratory variability, several findings suggest a pathogenic role of these a...

journal_title：Advances in clinical chemistry

authors： Alessandri C,Bombardieri M,Valesini G

更新日期：2006-01-01 00:00:00

abstract：:Multidrug resistance represents a major obstacle in the successful therapy of neoplastic diseases. Studies have demonstrated that this form of drug resistance occurs in cultured tumor cell lines as well as in human cancers. P-glycoprotein appears to play an important role in such cells by acting as an energy-dependent...

journal_title：Advances in clinical chemistry

authors： Bellamy WT,Dalton WS

更新日期：1994-01-01 00:00:00

abstract：:The cellular receptor for urokinase, urokinase-type plasminogen activator receptor (uPAR) plays a central role in localizing its ligand, urokinase-type plasminogen activator (uPA) and thereby the plasminogen activation to the cell surface. uPA converts the proenzyme plasminogen to plasmin, which is involved in degrada...

journal_title：Advances in clinical chemistry

authors： Høyer-Hansen G,Lund IK

更新日期：2007-01-01 00:00:00

abstract：:Aromatase is a specific component of the cytochrome P450 enzyme system that is responsible for the transformation of C19 androgen precursors into C18 estrogenic compounds. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is expressed in ovary and testis not only but also in many extraglan...

journal_title：Advances in clinical chemistry

authors： Gennari L,Merlotti D,Nuti R

更新日期：2011-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease occurs in significant percentage of general population. NAFLD is closely associated with entire spectrum of metabolic-related disorders including diabetes, obesity, and cardiovascular diseases. Considering several similar pathways underpinning metabol...

journal_title：Advances in clinical chemistry

authors： Shabani P,Emamgholipour S,Doosti M

更新日期：2017-01-01 00:00:00

abstract：:Sepsis is the primary cause of death in the intensive care unit. The prevention of sepsis complications requires an early and accurate diagnosis as well as the appropriate mon itoring. A deep knowledge of the immunologic basis of sepsis is essential to better understand the scope of incorporating a new marker into cli...

journal_title：Advances in clinical chemistry

authors： Prieto B,Alvarez Menéndez FV

更新日期：2014-01-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of other types of cancer, patients with mesothelioma currently face ...

journal_title：Advances in clinical chemistry

authors： Rodríguez Portal JA

更新日期：2012-01-01 00:00:00

abstract：:Human adults produce around 1000 mmol of ammonia daily. Some is reutilized in biosynthesis. The remainder is waste and neurotoxic. Eventually most is excreted in urine as urea, together with ammonia used as a buffer. In extrahepatic tissues, ammonia is incorporated into nontoxic glutamine and released into blood. Larg...

journal_title：Advances in clinical chemistry

authors： Walker V

更新日期：2014-01-01 00:00:00

abstract：:Aggressive behavior exerts an enormous impact on society remaining among the main causes of worldwide premature death. Effective primary interventions, relying on predictive models of aggression that show adequate sensitivity and specificity are currently lacking. One strategy to increase the accuracy and precision of...

journal_title：Advances in clinical chemistry

authors： Manchia M,Comai S,Pinna M,Pinna F,Fanos V,Denovan-Wright E,Carpiniello B

更新日期：2019-01-01 00:00:00

abstract：:During winter hibernation, small mammals fall into long periods of deep cold torpor where metabolic rate is suppressed by > 90% and core body temperature can fall to near 0 degrees C. Studies with hibernators illustrate the molecular regulatory mechanisms that coordinate the suppression of metabolic functions during t...

journal_title：Advances in clinical chemistry

authors： Storey KB,Storey JM

更新日期：2010-01-01 00:00:00

abstract：:Marine organisms are a rich source of sulfated polysaccharides with unique structures. Fucosylated chondroitin sulfate (FucCS) from the sea cucumber Ludwigothurea grisea and sulfated galactan from the red alga Botryocladia occidentalis are one of these unusual molecules. Besides their uncommon structures, they also ex...

journal_title：Advances in clinical chemistry

authors： Glauser BF,Mourão PA,Pomin VH

更新日期：2013-01-01 00:00:00

abstract：:Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control and manipulation, enabling rapid and high-throughput sample processing in integrated micro-scale medical systems. These platforms are well-suited for both standard clinical settings and point-of-care applications. The uni...

journal_title：Advances in clinical chemistry

authors： Burklund A,Tadimety A,Nie Y,Hao N,Zhang JXJ

更新日期：2020-01-01 00:00:00

abstract：:The application of simple, cost-effective, rapid, and accurate diagnostic technologies for detection and identification of cardiac and cancer biomarkers has been a central point in the clinical area. Biosensors have been recognized as efficient alternatives for the diagnostics of various diseases due to their specific...

journal_title：Advances in clinical chemistry

authors： Justino CI,Duarte AC,Rocha-Santos TA

更新日期：2016-01-01 00:00:00

abstract：:Menopause is a risk factor for cardiometabolic diseases, including metabolic syndrome (MetS), type 2 diabetes, and cardiovascular diseases. MetS is a constellation of interdependent factors such as insulin resistance, abdominal obesity, dyslipidemia, and hypertension. The prevalence of MetS in postmenopause is due to ...

journal_title：Advances in clinical chemistry

authors： Stefanska A,Bergmann K,Sypniewska G

更新日期：2015-01-01 00:00:00

abstract：:The abnormal breakdown of circulating red blood cells (RBCs), also known as hemolysis, is a significant clinical issue that can present as a primary disorder or arise secondary to another disease process. The evaluation for pathologic hemolysis (and the establishment of a hemolytic disorder) is heavily dependent on as...

journal_title：Advances in clinical chemistry

authors： Siddon AJ,Tormey CA

更新日期：2019-01-01 00:00:00

abstract：:This chapter summarizes progress in several approaches and devices that will improve and augment existing diagnostic techniques. The term bionanotechnology has been used to describe the science that supports the construction of nanoscale bioassemblies. In each of the present applications to diagnostics, bionanotechnol...

journal_title：Advances in clinical chemistry

authors： Clark J,Smith SS

更新日期：2006-01-01 00:00:00

abstract：:Cataract is a major cause of blindness worldwide. It is characterized by lens opacification and is accompanied by extensive posttranslational modifications (PTMs) in various proteins. PTMs play an essential role in lens opacification. Several PTMs have been described in proteins isolated from relatively old human lens...

journal_title：Advances in clinical chemistry

authors： Zhang K,Zhu X,Lu Y

更新日期：2018-01-01 00:00:00

abstract：:Biomarkers are increasingly employed in empirical studies of human populations to understand physiological processes that change with age, diseases whose onset appears linked to age, and the aging process itself. In this chapter, we describe some of the most commonly used biomarkers in population aging research, inclu...

journal_title：Advances in clinical chemistry

authors： Crimmins E,Vasunilashorn S,Kim JK,Alley D

更新日期：2008-01-01 00:00:00

abstract：:Mechanisms postulated to link folate and B12 metabolism with cancer, including genome-wide hypomethylation, gene-specific promoter hypermethylation, and DNA uracil misincorporation, have been observed in prostate tumor cells. However, epidemiological studies of prostate cancer risk, based on dietary intakes and blood ...

journal_title：Advances in clinical chemistry

authors： Collin SM

更新日期：2013-01-01 00:00:00

abstract：:Glutathione (GSH), often referred to as "the master antioxidant," participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damage and thus as expected, GSH imbalance is observed in a wide range of ...

journal_title：Advances in clinical chemistry

authors： Teskey G,Abrahem R,Cao R,Gyurjian K,Islamoglu H,Lucero M,Martinez A,Paredes E,Salaiz O,Robinson B,Venketaraman V

更新日期：2018-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD), the most common liver disorder worldwide, encompasses a spectrum of abnormal liver histology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Population studies show that NAFLD is strongly associated with insulin resistance, obesity, type 2 d...

journal_title：Advances in clinical chemistry

authors： Armutcu F,Akyol S,Ucar F,Erdogan S,Akyol O

更新日期：2013-01-01 00:00:00

abstract：:Metaproteomics, as a subfield of proteomics, has quickly emerged as a pivotal tool for global characterization of a microbiome system at a functional level. It has been increasingly applied in studying human digestive and metabolic diseases, and provides information-rich data to identify the dysbiosis of human gut mic...

journal_title：Advances in clinical chemistry

authors： Pan S,Chen R

更新日期：2020-01-01 00:00:00

abstract：:The majority of cancer-related deaths result from metastasis, the process by which cancer cells escape the primary tumor site and enter into the blood circulation in order to disseminate to secondary locations throughout the body. Tumor cells found within the circulation are referred to as circulating tumor cells (CTC...

journal_title：Advances in clinical chemistry

authors： Lowes LE,Allan AL

更新日期：2018-01-01 00:00:00

abstract：:In addition to their historical role, autoantibodies appear promising as biomarkers to facilitate diagnosis, improve patient outcome and decrease mortality in cancer. Autoantibodies may also be useful in the identification of subjects at risk for cancer, that is, those bearing premalignant changes. Numerous studies ha...

journal_title：Advances in clinical chemistry

authors： Fernández-Madrid F,Maroun MC

更新日期：2014-01-01 00:00:00