Abstract：
:Aromatase is a specific component of the cytochrome P450 enzyme system that is responsible for the transformation of C19 androgen precursors into C18 estrogenic compounds. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is expressed in ovary and testis not only but also in many extraglandular sites such as the placenta, brain, adipose tissue, and bone. The regulation of the level and activity of aromatase determines the levels of estrogens that have endocrine, paracrine, and autocrine effects on target issues including bone. Importantly, extraglandular aromatization of circulating androgen precursors is the major source of estrogen not only in men (since only 15% of circulating estradiol is released directly by the testis) but also in women after the menopause. Several lines of clinical and experimental evidence now clearly indicate that aromatase activity and estrogen production are necessary for longitudinal bone growth, attainment of peak bone mass, the pubertal growth spurt, epiphyseal closure, and normal bone remodeling in young individuals. Moreover, with aging, individual differences in aromatase activity and thus in estrogen levels may significantly affect bone loss and fracture risk in both genders.
journal_name
Adv Clin Chemjournal_title
Advances in clinical chemistryauthors
Gennari L,Merlotti D,Nuti Rdoi
10.1016/b978-0-12-387025-4.00006-6subject
Has Abstractpub_date
2011-01-01 00:00:00pages
129-64eissn
0065-2423issn
2162-9471journal_volume
54pub_type
杂志文章,评审abstract：:Exercise is a well-known non-pharmacologic agent used to prevent and treat a wide range of pathologic conditions such as metabolic and cardiovascular disease. In this sense, the classic field of exercise physiology has determined the main theoretical and practical bases of physiologic adaptations in response to exerci...
journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2015.10.004
更新日期：2016-01-01 00:00:00
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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doi：10.1016/bs.acc.2018.05.005
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journal_title：Advances in clinical chemistry
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更新日期：2012-01-01 00:00:00
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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更新日期：2007-01-01 00:00:00
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journal_title：Advances in clinical chemistry
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abstract：:Hypoxemia (systemic oxygen desaturation) marks the presence, risk, and progression of many diseases. Episodic or nocturnal hypoxemia can be challenging to detect and quantify. A sensitive, specific, and convenient marker of recent oxygen desaturation represents an unmet medical need. Observations of acclimatization to...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.06.002
更新日期：2017-01-01 00:00:00
