Abstract：
:Metabolomics is the quantitative analysis of a large number of low molecular weight metabolites that are intermediate or final products of all the metabolic pathways in a living organism. Any metabolic profiles detectable in a human biological fluid are caused by the interaction between gene expression and the environment. The metabolomics approach offers the possibility to identify variations in metabolite profile that can be used to discriminate disease. This is particularly important for neonatal and pediatric studies especially for severe ill patient diagnosis and early identification. This property is of a great clinical importance in view of the newer definitions of health and disease. This review emphasizes the workflow of a typical metabolomics study and summarizes the latest results obtained in neonatal studies with particular interest in prematurity, intrauterine growth retardation, inborn errors of metabolism, perinatal asphyxia, sepsis, necrotizing enterocolitis, kidney disease, bronchopulmonary dysplasia, and cardiac malformation and dysfunction.
journal_name
Adv Clin Chemjournal_title
Advances in clinical chemistryauthors
Noto A,Fanos V,Dessì Adoi
10.1016/bs.acc.2015.12.006subject
Has Abstractpub_date
2016-01-01 00:00:00pages
35-61eissn
0065-2423issn
2162-9471pii
S0065-2423(15)30006-8journal_volume
74pub_type
杂志文章,评审abstract：:Biomarkers are increasingly employed in empirical studies of human populations to understand physiological processes that change with age, diseases whose onset appears linked to age, and the aging process itself. In this chapter, we describe some of the most commonly used biomarkers in population aging research, inclu...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(08)00405-8
更新日期：2008-01-01 00:00:00
abstract：:Aromatase is a specific component of the cytochrome P450 enzyme system that is responsible for the transformation of C19 androgen precursors into C18 estrogenic compounds. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is expressed in ovary and testis not only but also in many extraglan...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-387025-4.00006-6
更新日期：2011-01-01 00:00:00
abstract：:Glutathione (GSH), often referred to as "the master antioxidant," participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damage and thus as expected, GSH imbalance is observed in a wide range of ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2018.07.004
更新日期：2018-01-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age affecting various functions including reproduction and metabolism. This syndrome is associated with increased prevalence of subclinical cardiovascular disease as well as endometrial and ovarian cancer. This syndrome is high...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2015.06.001
更新日期：2015-01-01 00:00:00
abstract：:Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system relies on molecules to directly quench ROS and the enzymatic system is composed of specific enzymes that detoxify ROS. Among the latter, the sup...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2014.11.001
更新日期：2015-01-01 00:00:00
abstract：:Human adults produce around 1000 mmol of ammonia daily. Some is reutilized in biosynthesis. The remainder is waste and neurotoxic. Eventually most is excreted in urine as urea, together with ammonia used as a buffer. In extrahepatic tissues, ammonia is incorporated into nontoxic glutamine and released into blood. Larg...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2014.09.002
更新日期：2014-01-01 00:00:00
abstract：:Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the alimentary tract, and E type PGs are most effective in these actions. PGE2 protects against acid reflux esophagitis and affords gastric cytoprotection against ethanol and indomethacin. These effects ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(10)51005-9
更新日期：2010-01-01 00:00:00
abstract：:In addition to their historical role, autoantibodies appear promising as biomarkers to facilitate diagnosis, improve patient outcome and decrease mortality in cancer. Autoantibodies may also be useful in the identification of subjects at risk for cancer, that is, those bearing premalignant changes. Numerous studies ha...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-800263-6.00005-7
更新日期：2014-01-01 00:00:00
abstract：:The generation of bulky DNA adducts consists of conjugates formed between large reactive electrophiles and DNA-binding sites. The term "bulky DNA adducts" comes from early experiments that employed a 32P-DNA postlabeling approach. This technique has long been used to elucidate the association between adducts and carci...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.01.006
更新日期：2017-01-01 00:00:00
abstract：:The cellular receptor for urokinase, urokinase-type plasminogen activator receptor (uPAR) plays a central role in localizing its ligand, urokinase-type plasminogen activator (uPA) and thereby the plasminogen activation to the cell surface. uPA converts the proenzyme plasminogen to plasmin, which is involved in degrada...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:The recognition that cardiac myocytes die by multiple mechanisms and thus substantially affect ventricular remodeling in diseased human hearts supports the concept of ongoing myocyte death in the progression of heart failure and constitutes the basis of this review. In addition, based on the pathophysiology of myocard...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(05)40002-5
更新日期：2005-01-01 00:00:00
abstract：:Circular RNAs (circRNAs) are covalently circularized RNA moieties that despite being relatively abundant were only recently identified and have only begun to be investigated within the last couple of years. Even though there are many thousands of genes that appear capable of producing circRNAs, and the fact that many ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/bs.acc.2020.02.008
更新日期：2020-01-01 00:00:00
abstract：:This chapter summarizes progress in several approaches and devices that will improve and augment existing diagnostic techniques. The term bionanotechnology has been used to describe the science that supports the construction of nanoscale bioassemblies. In each of the present applications to diagnostics, bionanotechnol...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/S0065-2423(05)41002-1
更新日期：2006-01-01 00:00:00
abstract：:The primary role of the clinical laboratory is to report accurate results for diagnosis of disease and management of illnesses. This goal has, to a large extent been achieved for routine biochemical tests, but not for immunoassays which remained susceptible to interference from endogenous immunoglobulin antibodies, ca...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-801401-1.00007-4
更新日期：2014-01-01 00:00:00
abstract：:Laboratory testing for drugs of abuse has become standard practice in many settings both forensic and clinical. Urine is the predominant specimen, but other specimens are possible including hair, nails, sweat, and oral fluid. Point-of-care test kits provide for rapid analysis at the site where specimens are collected ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/bs.acc.2016.11.003
更新日期：2017-01-01 00:00:00
abstract：:This review examines in vitro and in vivo studies, indicating that bilirubin inhibits lipid oxidation and oxygen radical formation. Experimental and epidemiological evidence is presented that suggests that bilirubin may serve as a physiological antioxidant providing protection against cardiovascular disease. Special a...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(10)50003-9
更新日期：2010-01-01 00:00:00
abstract：:The majority of cancer-related deaths result from metastasis, the process by which cancer cells escape the primary tumor site and enter into the blood circulation in order to disseminate to secondary locations throughout the body. Tumor cells found within the circulation are referred to as circulating tumor cells (CTC...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.10.004
更新日期：2018-01-01 00:00:00
abstract：:The abnormal breakdown of circulating red blood cells (RBCs), also known as hemolysis, is a significant clinical issue that can present as a primary disorder or arise secondary to another disease process. The evaluation for pathologic hemolysis (and the establishment of a hemolytic disorder) is heavily dependent on as...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2018.12.006
更新日期：2019-01-01 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD), the most common liver disorder worldwide, encompasses a spectrum of abnormal liver histology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Population studies show that NAFLD is strongly associated with insulin resistance, obesity, type 2 d...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-407680-8.00004-x
更新日期：2013-01-01 00:00:00
abstract：:Metaproteomics, as a subfield of proteomics, has quickly emerged as a pivotal tool for global characterization of a microbiome system at a functional level. It has been increasingly applied in studying human digestive and metabolic diseases, and provides information-rich data to identify the dysbiosis of human gut mic...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.12.002
更新日期：2020-01-01 00:00:00
abstract：:Since the discovery of group-specific component and its polymorphism by Hirschfeld in 1959, research has put spotlight on this multifunctional transport protein (vitamin D binding protein, DBP). Besides the transport of vitamin D metabolites, DBP is a plasma glycoprotein with many important functions, including seques...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-800094-6.00001-7
更新日期：2014-01-01 00:00:00
abstract：:During winter hibernation, small mammals fall into long periods of deep cold torpor where metabolic rate is suppressed by > 90% and core body temperature can fall to near 0 degrees C. Studies with hibernators illustrate the molecular regulatory mechanisms that coordinate the suppression of metabolic functions during t...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control and manipulation, enabling rapid and high-throughput sample processing in integrated micro-scale medical systems. These platforms are well-suited for both standard clinical settings and point-of-care applications. The uni...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.08.001
更新日期：2020-01-01 00:00:00
abstract：:Deregulated DNA replication occurs in cancer where it contributes to genomic instability. This process is a target of cytotoxic therapies. Chemotherapies exploit high DNA replication in cancer cells by modifying the DNA template or by inhibiting vital enzymatic activities that lead to slowing or stalling replication f...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2014.12.003
更新日期：2015-01-01 00:00:00
abstract：:This monograph on the clinical chemistry of vitamin B12 reviews the literature on daily requirements, methods for measurement, the effects of drugs on vitamin B12 metabolism absorption, pregnancy, clinical conditions associated with vitamin B12 deficiency, errors of metabolism, and reactions to vitamin therapy. Altho...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(08)60273-5
更新日期：1985-01-01 00:00:00
abstract：:Exercise is a well-known non-pharmacologic agent used to prevent and treat a wide range of pathologic conditions such as metabolic and cardiovascular disease. In this sense, the classic field of exercise physiology has determined the main theoretical and practical bases of physiologic adaptations in response to exerci...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.11.003
更新日期：2020-01-01 00:00:00
abstract：:Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity o...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-394317-0.00012-1
更新日期：2012-01-01 00:00:00
abstract：:The application of simple, cost-effective, rapid, and accurate diagnostic technologies for detection and identification of cardiac and cancer biomarkers has been a central point in the clinical area. Biosensors have been recognized as efficient alternatives for the diagnostics of various diseases due to their specific...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2015.10.004
更新日期：2016-01-01 00:00:00
abstract：:Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of other types of cancer, patients with mesothelioma currently face ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Hypertensive disorders of pregnancy (HDP) is the most common and widely known as serious complication of pregnancy. As this syndrome is a major leading cause of maternal, fetal, and neonatal morbidity/mortality worldwide, many studies have sought to identify candidate molecules as potential disease biomarkers (DBMs) f...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.07.007
更新日期：2020-01-01 00:00:00
