Abstract：
:Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of other types of cancer, patients with mesothelioma currently face a poor prognosis. Therefore, it is highly important to develop an early diagnostic method with the greatest challenge on screening techniques to detect the disease at a subclinical stage. Early detection is critical for the development of more effective therapies in these patients. Unfortunately, radiologic studies have not proven effective. Biomarkers might be a useful adjunct tool among populations previously exposed to asbestos. This review will provide an update of recent progress in serum biomarkers (osteopontin (OPN), soluble mesothelin (SM), and megakaryocyte potentiating factor (MPF)) to diagnose, detect, and monitor MPM. Of these, SM has demonstrated the greatest diagnostic potential although MPF may serve as an equal alternative. Despite recent studies, it is apparent that long-term large-cohort research is required to conclusively demonstrate the usefulness of these markers in this disease.
journal_name
Adv Clin Chemjournal_title
Advances in clinical chemistryauthors
Rodríguez Portal JAsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
163-85eissn
0065-2423issn
2162-9471journal_volume
57pub_type
杂志文章,评审abstract：:Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the alimentary tract, and E type PGs are most effective in these actions. PGE2 protects against acid reflux esophagitis and affords gastric cytoprotection against ethanol and indomethacin. These effects ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(10)51005-9
更新日期：2010-01-01 00:00:00
abstract：:The majority of cancer-related deaths result from metastasis, the process by which cancer cells escape the primary tumor site and enter into the blood circulation in order to disseminate to secondary locations throughout the body. Tumor cells found within the circulation are referred to as circulating tumor cells (CTC...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.10.004
更新日期：2018-01-01 00:00:00
abstract：:Although the measures to improve quality in the clinical laboratory have been enormous in the past years, not least of all due to the introduction of the ISO standards 15189 and 17025, the handling of validation and verification of method performance often still differs widely from laboratory to laboratory. Much of wh...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.01.006
更新日期：2019-01-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age affecting various functions including reproduction and metabolism. This syndrome is associated with increased prevalence of subclinical cardiovascular disease as well as endometrial and ovarian cancer. This syndrome is high...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2015.06.001
更新日期：2015-01-01 00:00:00
abstract：:This chapter summarizes progress in several approaches and devices that will improve and augment existing diagnostic techniques. The term bionanotechnology has been used to describe the science that supports the construction of nanoscale bioassemblies. In each of the present applications to diagnostics, bionanotechnol...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/S0065-2423(05)41002-1
更新日期：2006-01-01 00:00:00
abstract：:Aromatase is a specific component of the cytochrome P450 enzyme system that is responsible for the transformation of C19 androgen precursors into C18 estrogenic compounds. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is expressed in ovary and testis not only but also in many extraglan...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-387025-4.00006-6
更新日期：2011-01-01 00:00:00
abstract：:The recognition that cardiac myocytes die by multiple mechanisms and thus substantially affect ventricular remodeling in diseased human hearts supports the concept of ongoing myocyte death in the progression of heart failure and constitutes the basis of this review. In addition, based on the pathophysiology of myocard...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(05)40002-5
更新日期：2005-01-01 00:00:00
abstract：:Publication of the human proteome has prompted efforts to develop high-throughput techniques that can catalogue and quantify proteins and peptides present in different tissue types. The field of proteomics aims to identify, quantify, analyze, and functionally define a large number of proteins in cellular processes in ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(09)47006-9
更新日期：2009-01-01 00:00:00
abstract：:Cataract is a major cause of blindness worldwide. It is characterized by lens opacification and is accompanied by extensive posttranslational modifications (PTMs) in various proteins. PTMs play an essential role in lens opacification. Several PTMs have been described in proteins isolated from relatively old human lens...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2018.05.005
更新日期：2018-01-01 00:00:00
abstract：:Menopause is a risk factor for cardiometabolic diseases, including metabolic syndrome (MetS), type 2 diabetes, and cardiovascular diseases. MetS is a constellation of interdependent factors such as insulin resistance, abdominal obesity, dyslipidemia, and hypertension. The prevalence of MetS in postmenopause is due to ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2015.07.001
更新日期：2015-01-01 00:00:00
abstract：:The abnormal breakdown of circulating red blood cells (RBCs), also known as hemolysis, is a significant clinical issue that can present as a primary disorder or arise secondary to another disease process. The evaluation for pathologic hemolysis (and the establishment of a hemolytic disorder) is heavily dependent on as...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2018.12.006
更新日期：2019-01-01 00:00:00
abstract：:Sepsis is the primary cause of death in the intensive care unit. The prevention of sepsis complications requires an early and accurate diagnosis as well as the appropriate mon itoring. A deep knowledge of the immunologic basis of sepsis is essential to better understand the scope of incorporating a new marker into cli...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-800141-7.00002-4
更新日期：2014-01-01 00:00:00
abstract：:This review examines in vitro and in vivo studies, indicating that bilirubin inhibits lipid oxidation and oxygen radical formation. Experimental and epidemiological evidence is presented that suggests that bilirubin may serve as a physiological antioxidant providing protection against cardiovascular disease. Special a...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(10)50003-9
更新日期：2010-01-01 00:00:00
abstract：:During winter hibernation, small mammals fall into long periods of deep cold torpor where metabolic rate is suppressed by > 90% and core body temperature can fall to near 0 degrees C. Studies with hibernators illustrate the molecular regulatory mechanisms that coordinate the suppression of metabolic functions during t...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Laboratory testing for drugs of abuse has become standard practice in many settings both forensic and clinical. Urine is the predominant specimen, but other specimens are possible including hair, nails, sweat, and oral fluid. Point-of-care test kits provide for rapid analysis at the site where specimens are collected ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/bs.acc.2016.11.003
更新日期：2017-01-01 00:00:00
abstract：:Human adults produce around 1000 mmol of ammonia daily. Some is reutilized in biosynthesis. The remainder is waste and neurotoxic. Eventually most is excreted in urine as urea, together with ammonia used as a buffer. In extrahepatic tissues, ammonia is incorporated into nontoxic glutamine and released into blood. Larg...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2014.09.002
更新日期：2014-01-01 00:00:00
abstract：:The generation of bulky DNA adducts consists of conjugates formed between large reactive electrophiles and DNA-binding sites. The term "bulky DNA adducts" comes from early experiments that employed a 32P-DNA postlabeling approach. This technique has long been used to elucidate the association between adducts and carci...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.01.006
更新日期：2017-01-01 00:00:00
abstract：:Since the discovery of group-specific component and its polymorphism by Hirschfeld in 1959, research has put spotlight on this multifunctional transport protein (vitamin D binding protein, DBP). Besides the transport of vitamin D metabolites, DBP is a plasma glycoprotein with many important functions, including seques...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-800094-6.00001-7
更新日期：2014-01-01 00:00:00
abstract：:Marine organisms are a rich source of sulfated polysaccharides with unique structures. Fucosylated chondroitin sulfate (FucCS) from the sea cucumber Ludwigothurea grisea and sulfated galactan from the red alga Botryocladia occidentalis are one of these unusual molecules. Besides their uncommon structures, they also ex...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/b978-0-12-800096-0.00007-x
更新日期：2013-01-01 00:00:00
abstract：:The recent development and introduction into clinical and laboratory practice of the novel highly sensitive cardiac troponin assays has contributed to improve the diagnosis and risk stratification of patients presenting with suspected myocardial injury and acute coronary syndrome at the emergency department (ED). The ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Aggressive behavior exerts an enormous impact on society remaining among the main causes of worldwide premature death. Effective primary interventions, relying on predictive models of aggression that show adequate sensitivity and specificity are currently lacking. One strategy to increase the accuracy and precision of...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.07.004
更新日期：2019-01-01 00:00:00
abstract：:Hypoxemia (systemic oxygen desaturation) marks the presence, risk, and progression of many diseases. Episodic or nocturnal hypoxemia can be challenging to detect and quantify. A sensitive, specific, and convenient marker of recent oxygen desaturation represents an unmet medical need. Observations of acclimatization to...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.06.002
更新日期：2017-01-01 00:00:00
abstract：:The primary role of the clinical laboratory is to report accurate results for diagnosis of disease and management of illnesses. This goal has, to a large extent been achieved for routine biochemical tests, but not for immunoassays which remained susceptible to interference from endogenous immunoglobulin antibodies, ca...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-801401-1.00007-4
更新日期：2014-01-01 00:00:00
abstract：:Circular RNAs (circRNAs) are covalently circularized RNA moieties that despite being relatively abundant were only recently identified and have only begun to be investigated within the last couple of years. Even though there are many thousands of genes that appear capable of producing circRNAs, and the fact that many ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/bs.acc.2020.02.008
更新日期：2020-01-01 00:00:00
abstract：:Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity o...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-394317-0.00012-1
更新日期：2012-01-01 00:00:00
abstract：:Mechanisms postulated to link folate and B12 metabolism with cancer, including genome-wide hypomethylation, gene-specific promoter hypermethylation, and DNA uracil misincorporation, have been observed in prostate tumor cells. However, epidemiological studies of prostate cancer risk, based on dietary intakes and blood ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-407681-5.00001-5
更新日期：2013-01-01 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease occurs in significant percentage of general population. NAFLD is closely associated with entire spectrum of metabolic-related disorders including diabetes, obesity, and cardiovascular diseases. Considering several similar pathways underpinning metabol...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2016.10.002
更新日期：2017-01-01 00:00:00
abstract：:The cellular receptor for urokinase, urokinase-type plasminogen activator receptor (uPAR) plays a central role in localizing its ligand, urokinase-type plasminogen activator (uPA) and thereby the plasminogen activation to the cell surface. uPA converts the proenzyme plasminogen to plasmin, which is involved in degrada...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:This monograph on the clinical chemistry of vitamin B12 reviews the literature on daily requirements, methods for measurement, the effects of drugs on vitamin B12 metabolism absorption, pregnancy, clinical conditions associated with vitamin B12 deficiency, errors of metabolism, and reactions to vitamin therapy. Altho...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(08)60273-5
更新日期：1985-01-01 00:00:00
abstract：:Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control and manipulation, enabling rapid and high-throughput sample processing in integrated micro-scale medical systems. These platforms are well-suited for both standard clinical settings and point-of-care applications. The uni...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.08.001
更新日期：2020-01-01 00:00:00
