Abstract：
:Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system relies on molecules to directly quench ROS and the enzymatic system is composed of specific enzymes that detoxify ROS. Among the latter, the superoxide dismutase (SOD) family is important in oxidative stress modulation. Of these, manganese-dependent SOD (MnSOD) plays a major role due to its mitochondrial location, i.e., the main site of superoxide (O(2)(·-)) production. As such, extensive research has focused on its capacity to modulate oxidative stress. Early data demonstrated the relevance of MnSOD as an O(2)(·-) scavenger. More recent research has, however, identified a prominent role for MnSOD in carcinogenesis. In addition, SOD downregulation appears associated with health risk in heart and brain. A single nucleotide polymorphism which alters the mitochondria signaling sequence for the cytosolic MnSOD form has been identified. Transport into the mitochondria was differentially affected by allelic presence and a new chapter in MnSOD research thus begun. As a result, an ever-increasing number of diseases appear associated with this allelic variation including metabolic and cardiovascular disease. Although diet and exercise upregulate MnSOD, the relationship between environmental and genetic factors remains unclear.
journal_name
Adv Clin Chemjournal_title
Advances in clinical chemistryauthors
Bresciani G,da Cruz IB,González-Gallego Jdoi
10.1016/bs.acc.2014.11.001subject
Has Abstractpub_date
2015-01-01 00:00:00pages
87-130eissn
0065-2423issn
2162-9471pii
S0065-2423(14)00010-9journal_volume
68pub_type
杂志文章,评审abstract：:This monograph on the clinical chemistry of vitamin B12 reviews the literature on daily requirements, methods for measurement, the effects of drugs on vitamin B12 metabolism absorption, pregnancy, clinical conditions associated with vitamin B12 deficiency, errors of metabolism, and reactions to vitamin therapy. Altho...
journal_title：Advances in clinical chemistry
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abstract：:Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of other types of cancer, patients with mesothelioma currently face ...
journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
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journal_title：Advances in clinical chemistry
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更新日期：2014-01-01 00:00:00
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.01.006
更新日期：2019-01-01 00:00:00
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.11.003
更新日期：2020-01-01 00:00:00
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/bs.acc.2016.11.003
更新日期：2017-01-01 00:00:00
abstract：:Glutathione (GSH), often referred to as "the master antioxidant," participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damage and thus as expected, GSH imbalance is observed in a wide range of ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2018.07.004
更新日期：2018-01-01 00:00:00
abstract：:The majority of cancer-related deaths result from metastasis, the process by which cancer cells escape the primary tumor site and enter into the blood circulation in order to disseminate to secondary locations throughout the body. Tumor cells found within the circulation are referred to as circulating tumor cells (CTC...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.10.004
更新日期：2018-01-01 00:00:00
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2015.07.001
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
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journal_title：Advances in clinical chemistry
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journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
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journal_title：Advances in clinical chemistry
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abstract：:There is now substantial evidence for the role of cyclooxygenase (COX)-2 in causation and prevention of cancer. Selective COX-2 inhibitors (coxibs) were considered attractive candidate chemoprevention agents; however, concerns over the toxicity of systemic selective inhibition have cast some doubt on COX-2 inhibition ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control and manipulation, enabling rapid and high-throughput sample processing in integrated micro-scale medical systems. These platforms are well-suited for both standard clinical settings and point-of-care applications. The uni...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.08.001
更新日期：2020-01-01 00:00:00
abstract：:Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the alimentary tract, and E type PGs are most effective in these actions. PGE2 protects against acid reflux esophagitis and affords gastric cytoprotection against ethanol and indomethacin. These effects ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(10)51005-9
更新日期：2010-01-01 00:00:00
abstract：:Marine organisms are a rich source of sulfated polysaccharides with unique structures. Fucosylated chondroitin sulfate (FucCS) from the sea cucumber Ludwigothurea grisea and sulfated galactan from the red alga Botryocladia occidentalis are one of these unusual molecules. Besides their uncommon structures, they also ex...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
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abstract：:Multidrug resistance represents a major obstacle in the successful therapy of neoplastic diseases. Studies have demonstrated that this form of drug resistance occurs in cultured tumor cell lines as well as in human cancers. P-glycoprotein appears to play an important role in such cells by acting as an energy-dependent...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(08)60332-7
更新日期：1994-01-01 00:00:00
