Abstract:
:Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease occurs in significant percentage of general population. NAFLD is closely associated with entire spectrum of metabolic-related disorders including diabetes, obesity, and cardiovascular diseases. Considering several similar pathways underpinning metabolic disorders, presence of common molecular mediators contributing to pathomechanism of these disorders is expected. Mounting evidence has demonstrated important role of adipokines in the context of NAFLD. Adipokines produced by different tissues, mainly adipose, modulate numerous pathways including glucose and fatty acid metabolism and inflammation. CTRPs (C1q/TNF-related proteins) are a recently identified family of adipokines in which adiponectin is the most well-known ones. CTRP1 is a member of this family which has captured attention in recent years. CTRP1 enhances glucose and fatty acid oxidation, improves insulin sensitivity, attenuates plaque formation, and increases aldosterone production. Hence, various roles in metabolic pathways can link CTRP1 to NAFLD pathogenesis.
journal_name
Adv Clin Chemjournal_title
Advances in clinical chemistryauthors
Shabani P,Emamgholipour S,Doosti Mdoi
10.1016/bs.acc.2016.10.002subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1-23eissn
0065-2423issn
2162-9471pii
S0065-2423(16)30096-8journal_volume
79pub_type
杂志文章,评审abstract::Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the alimentary tract, and E type PGs are most effective in these actions. PGE2 protects against acid reflux esophagitis and affords gastric cytoprotection against ethanol and indomethacin. These effects ...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/s0065-2423(10)51005-9
更新日期:2010-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age affecting various functions including reproduction and metabolism. This syndrome is associated with increased prevalence of subclinical cardiovascular disease as well as endometrial and ovarian cancer. This syndrome is high...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2015.06.001
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abstract::Menopause is a risk factor for cardiometabolic diseases, including metabolic syndrome (MetS), type 2 diabetes, and cardiovascular diseases. MetS is a constellation of interdependent factors such as insulin resistance, abdominal obesity, dyslipidemia, and hypertension. The prevalence of MetS in postmenopause is due to ...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2015.07.001
更新日期:2015-01-01 00:00:00
abstract::The recognition that cardiac myocytes die by multiple mechanisms and thus substantially affect ventricular remodeling in diseased human hearts supports the concept of ongoing myocyte death in the progression of heart failure and constitutes the basis of this review. In addition, based on the pathophysiology of myocard...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/s0065-2423(05)40002-5
更新日期:2005-01-01 00:00:00
abstract::Metabolomics is the quantitative analysis of a large number of low molecular weight metabolites that are intermediate or final products of all the metabolic pathways in a living organism. Any metabolic profiles detectable in a human biological fluid are caused by the interaction between gene expression and the environ...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2015.12.006
更新日期:2016-01-01 00:00:00
abstract::Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control and manipulation, enabling rapid and high-throughput sample processing in integrated micro-scale medical systems. These platforms are well-suited for both standard clinical settings and point-of-care applications. The uni...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2019.08.001
更新日期:2020-01-01 00:00:00
abstract::Aromatase is a specific component of the cytochrome P450 enzyme system that is responsible for the transformation of C19 androgen precursors into C18 estrogenic compounds. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is expressed in ovary and testis not only but also in many extraglan...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/b978-0-12-387025-4.00006-6
更新日期:2011-01-01 00:00:00
abstract::Although the measures to improve quality in the clinical laboratory have been enormous in the past years, not least of all due to the introduction of the ISO standards 15189 and 17025, the handling of validation and verification of method performance often still differs widely from laboratory to laboratory. Much of wh...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2019.01.006
更新日期:2019-01-01 00:00:00
abstract::Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system relies on molecules to directly quench ROS and the enzymatic system is composed of specific enzymes that detoxify ROS. Among the latter, the sup...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2014.11.001
更新日期:2015-01-01 00:00:00
abstract::The cellular receptor for urokinase, urokinase-type plasminogen activator receptor (uPAR) plays a central role in localizing its ligand, urokinase-type plasminogen activator (uPA) and thereby the plasminogen activation to the cell surface. uPA converts the proenzyme plasminogen to plasmin, which is involved in degrada...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::In addition to their historical role, autoantibodies appear promising as biomarkers to facilitate diagnosis, improve patient outcome and decrease mortality in cancer. Autoantibodies may also be useful in the identification of subjects at risk for cancer, that is, those bearing premalignant changes. Numerous studies ha...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/b978-0-12-800263-6.00005-7
更新日期:2014-01-01 00:00:00
abstract::Publication of the human proteome has prompted efforts to develop high-throughput techniques that can catalogue and quantify proteins and peptides present in different tissue types. The field of proteomics aims to identify, quantify, analyze, and functionally define a large number of proteins in cellular processes in ...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/s0065-2423(09)47006-9
更新日期:2009-01-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD), the most common liver disorder worldwide, encompasses a spectrum of abnormal liver histology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Population studies show that NAFLD is strongly associated with insulin resistance, obesity, type 2 d...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/b978-0-12-407680-8.00004-x
更新日期:2013-01-01 00:00:00
abstract::This review examines in vitro and in vivo studies, indicating that bilirubin inhibits lipid oxidation and oxygen radical formation. Experimental and epidemiological evidence is presented that suggests that bilirubin may serve as a physiological antioxidant providing protection against cardiovascular disease. Special a...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/s0065-2423(10)50003-9
更新日期:2010-01-01 00:00:00
abstract::During winter hibernation, small mammals fall into long periods of deep cold torpor where metabolic rate is suppressed by > 90% and core body temperature can fall to near 0 degrees C. Studies with hibernators illustrate the molecular regulatory mechanisms that coordinate the suppression of metabolic functions during t...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00
abstract::Hypoxemia (systemic oxygen desaturation) marks the presence, risk, and progression of many diseases. Episodic or nocturnal hypoxemia can be challenging to detect and quantify. A sensitive, specific, and convenient marker of recent oxygen desaturation represents an unmet medical need. Observations of acclimatization to...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2017.06.002
更新日期:2017-01-01 00:00:00
abstract::Human adults produce around 1000 mmol of ammonia daily. Some is reutilized in biosynthesis. The remainder is waste and neurotoxic. Eventually most is excreted in urine as urea, together with ammonia used as a buffer. In extrahepatic tissues, ammonia is incorporated into nontoxic glutamine and released into blood. Larg...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2014.09.002
更新日期:2014-01-01 00:00:00
abstract::The majority of cancer-related deaths result from metastasis, the process by which cancer cells escape the primary tumor site and enter into the blood circulation in order to disseminate to secondary locations throughout the body. Tumor cells found within the circulation are referred to as circulating tumor cells (CTC...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2017.10.004
更新日期:2018-01-01 00:00:00
abstract::Laboratory testing for drugs of abuse has become standard practice in many settings both forensic and clinical. Urine is the predominant specimen, but other specimens are possible including hair, nails, sweat, and oral fluid. Point-of-care test kits provide for rapid analysis at the site where specimens are collected ...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章
doi:10.1016/bs.acc.2016.11.003
更新日期:2017-01-01 00:00:00
abstract::Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of other types of cancer, patients with mesothelioma currently face ...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
abstract::Biomarkers are increasingly employed in empirical studies of human populations to understand physiological processes that change with age, diseases whose onset appears linked to age, and the aging process itself. In this chapter, we describe some of the most commonly used biomarkers in population aging research, inclu...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/s0065-2423(08)00405-8
更新日期:2008-01-01 00:00:00
abstract::Metaproteomics, as a subfield of proteomics, has quickly emerged as a pivotal tool for global characterization of a microbiome system at a functional level. It has been increasingly applied in studying human digestive and metabolic diseases, and provides information-rich data to identify the dysbiosis of human gut mic...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2019.12.002
更新日期:2020-01-01 00:00:00
abstract::In Part II of this review we consider the very common case of multiple inputs to a measurement process. We derive, using only elementary steps and the basic mathematics covered in Part I, the formula for the propagation of uncertainties from the inputs to the output. The Gaussian density distribution is briefly explai...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2018.02.003
更新日期:2018-01-01 00:00:00
abstract::Multidrug resistance represents a major obstacle in the successful therapy of neoplastic diseases. Studies have demonstrated that this form of drug resistance occurs in cultured tumor cell lines as well as in human cancers. P-glycoprotein appears to play an important role in such cells by acting as an energy-dependent...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/s0065-2423(08)60332-7
更新日期:1994-01-01 00:00:00
abstract::Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity o...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/b978-0-12-394317-0.00012-1
更新日期:2012-01-01 00:00:00
abstract::The recent development and introduction into clinical and laboratory practice of the novel highly sensitive cardiac troponin assays has contributed to improve the diagnosis and risk stratification of patients presenting with suspected myocardial injury and acute coronary syndrome at the emergency department (ED). The ...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
abstract::This chapter summarizes progress in several approaches and devices that will improve and augment existing diagnostic techniques. The term bionanotechnology has been used to describe the science that supports the construction of nanoscale bioassemblies. In each of the present applications to diagnostics, bionanotechnol...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/S0065-2423(05)41002-1
更新日期:2006-01-01 00:00:00
abstract::The application of simple, cost-effective, rapid, and accurate diagnostic technologies for detection and identification of cardiac and cancer biomarkers has been a central point in the clinical area. Biosensors have been recognized as efficient alternatives for the diagnostics of various diseases due to their specific...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2015.10.004
更新日期:2016-01-01 00:00:00
abstract::Anti-endothelial cell antibodies (AECA) represent a heterogeneous family of autoantibodies directed against structural endothelial proteins, as well as antigens adhering to endothelial cells. Although AECA immunoassays still show a high-interlaboratory variability, several findings suggest a pathogenic role of these a...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/s0065-2423(06)42008-4
更新日期:2006-01-01 00:00:00
abstract::The generation of bulky DNA adducts consists of conjugates formed between large reactive electrophiles and DNA-binding sites. The term "bulky DNA adducts" comes from early experiments that employed a 32P-DNA postlabeling approach. This technique has long been used to elucidate the association between adducts and carci...
journal_title:Advances in clinical chemistry
pub_type: 杂志文章,评审
doi:10.1016/bs.acc.2017.01.006
更新日期:2017-01-01 00:00:00