Abstract:
:Since the discovery of group-specific component and its polymorphism by Hirschfeld in 1959, research has put spotlight on this multifunctional transport protein (vitamin D binding protein, DBP). Besides the transport of vitamin D metabolites, DBP is a plasma glycoprotein with many important functions, including sequestration of actin, modulation of immune and inflammatory responses, binding of fatty acids, and control of bone development. A considerable DBP polymorphism has been described with a specific allele distribution in different geographic area. Multiple studies have shed light on the interesting relationship between polymorphisms of the DBP gene and the susceptibility to diseases. In this review, we give an overview of the multifunctional character of DBP and describe the clinical importance of DBP and its polymorphisms. Finally, we discuss the possibilities to use DBP as a novel therapeutic agent.
journal_name
Adv Clin Chemjournal_title
Advances in clinical chemistryauthors
Speeckaert MM,Speeckaert R,van Geel N,Delanghe JRdoi
10.1016/b978-0-12-800094-6.00001-7subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1-57eissn
0065-2423issn
2162-9471journal_volume
63pub_type
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